A Rare Presentation of Gastric Adenocarcinoma with Acute Pulmonary Embolism and Fatal Acute Disseminated Intravascular Coagulation

2006 ◽  
Vol 101 ◽  
pp. S357
Author(s):  
Ranjith Wijeratne ◽  
Wichit Srikureja ◽  
Hamid Mirshahidi
Keyword(s):  
Pulmonary Embolism ◽  
Gastric Adenocarcinoma ◽  
Disseminated Intravascular Coagulation ◽  
Acute Pulmonary Embolism ◽  
Rare Presentation ◽  
Intravascular Coagulation

scholarly journals Disseminated Intravascular Coagulation and Malignancy: A Case Report and Literature Review

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Sumit Sohal ◽  
Akhilesh Thakur ◽  
Aleena Zia ◽  
Mina Sous ◽  
Daniela Trelles
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Embolism ◽  
Cardiac Arrest ◽  
Disseminated Intravascular Coagulation ◽  
Limb Ischemia ◽  
Symptomatic Treatment ◽  
Malignant Cells ◽  
Intravascular Coagulation ◽  
Fluid Analysis ◽  
History Of

Disseminated Intravascular Coagulation (DIC) is a disorder of coagulation which is commonly seen as a complication of infections, traumas, obstetric diseases, and cancers especially hematological and rarely solid cancers. DIC may rarely be the presenting feature of an undiagnosed malignancy. It may present in the form of different phenotypes which makes its diagnosis difficult and leads to high mortality. The treatment comprises supportive, symptomatic treatment and removal of the underlying source. Here, we present a patient with history of being on warfarin for atrial fibrillation and other comorbidities who presented with elevated INR of 6.3 and increasing dyspnea on exertion. Over the course of her stay, her platelet counts started dropping with a concurrent decrease in fibrinogen levels. She eventually developed pulmonary embolism, followed by stroke and limb ischemia, which was indicative of the thrombotic phenotype of DIC. Her pleural fluid analysis showed huge burden of malignant cells in glandular pattern suggestive of adenocarcinoma and was started on heparin drip. However, the patient had cardiac arrest and expired on the same day of diagnosis.

scholarly journals P230 Pulmonary embolism due to hepatocellular carcinoma: A rare presentation

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Hassan Abdelnabi ◽  
Y Saleh ◽  
A Almaghraby ◽  
O Tok ◽  
H Shehata ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Pulmonary Embolism ◽  
Acute Pulmonary Embolism ◽  
Cardiac Involvement ◽  
Malignant Tumors ◽  
Vena Cava ◽  
High Rate ◽  
Contrast Study ◽  
Rare Presentation ◽  
Tumor Thrombi

Abstract Introduction Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the second leading cause of cancer-related deaths. HCC is a highly progressive cancer with a high rate of metastasis. Intra-cardiac involvement with HCC is quite rare with a very poor prognosis. Acute pulmonary embolism is a very rare presentation of hepatocellular carcinoma (HCC) complicated with tumor thrombi into the inferior vena cava (IVC), right atrium (RA) and right ventricle (RV) with very poor reported prognosis. Case presentation A 72-years old hepatitis C virus (HCV) positive male patient for 20 years but he didn’t receive any treatment. He was admitted at our medical faculty with decompensated liver failure and resolved hepatic encephalopathy. He started complaining of acute onset of dyspnea. On clinical examination, he was tachypneic, tachycardic with thready pulse, distressed with deep icteric tinge. He had a massive ascites and bilateral lower limb pitting oedema. His electrocardiogram (ECG) showed sinus tachycardia. Urgent transthoracic echocardiography (TTE) revealed a large solid mass extending through the IVC to RA (Figure 1 Panel A) with another highly mobile cauliflower mass at the RV apex occupying the RV cavity, protruding into RA through TV and nearly obliterating RVOT into pulmonary artery. (Figure 1 Panel B, C, D). Due to patient’s frailty and hazards of contrast medium in an already impaired renal status of him, no further contrast study was performed. Only conservative and supportive measures were initiated for the management of his deteriorated general condition but unfortunately, he passed away shortly after. Conclusion Cardiac involvement in HCC rarely occurs and usually develops in advanced stages of HCC. The main mechanism of metastasis into the cardiac cavity is through a direct vascular extension of the tumor to the right side via hepatic vein and IVC. Acute pulmonary embolism in the setting of HCC is a quite rare manifestation of HCC that usually occur due to tumor thrombi in the IVC, RA and RV. The reported prognosis of HCC with intra-cardiac involvement is very poor, with a mean survival of 1 to 4 months at the time of diagnosis. Abstract P230 Figure. TTE of HCC invading RVOT

scholarly journals Disseminated Intravascular Coagulation in a Case of Gastric Adenocarcinoma

2015 ◽  
Vol 53 (3) ◽  
pp. 251-252
Author(s):  
Betül Çavuşoğlu ◽  
Süleyman Ahbab ◽  
Faik Çetin ◽  
Esra Ataoğlu ◽  
Mustafa Yenigün
Keyword(s):  
Gastric Adenocarcinoma ◽  
Disseminated Intravascular Coagulation ◽  
Intravascular Coagulation

scholarly journals A unique tale of COVID-19 induced concomitant overt disseminated intravascular coagulation and acute bilateral pulmonary embolism

2021 ◽  
Vol 104 ◽  
pp. 568-571
Author(s):  
Saquib Navid Siddiqui ◽  
Roland Jayasekhar ◽  
Sonam Tshering ◽  
Ranjana Jugjali ◽  
Devipangaj Shanmugavadivel ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Disseminated Intravascular Coagulation ◽  
Intravascular Coagulation

scholarly journals Disseminated Intravascular Coagulation in a Case of Brucellosis

2010 ◽  
Vol 17 (6) ◽  
pp. E10-E12 ◽  
Author(s):  
Sinan Akbayram ◽  
Murat Dogan ◽  
Cihangir Akgun ◽  
Erdal Peker ◽  
Mehmet Parlak ◽  
...  
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Brucella Melitensis ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Rare Presentation ◽  
Multisystem Disease ◽  
Laboratory Findings ◽  
Intravascular Coagulation ◽  
Hematological Abnormalities ◽  
Time Of Admission

Brucellosis is a multisystem disease with a broad spectrum of clinical manifestations; hematological abnormalities ranging from fulminant as of disseminated intravascular coagulation (DIC) to anaemia, leucopoenia, thrombocytopenia, and clotting disorders. In this report, we present DIC in a case of brucellosis because of rare presentation. A 3-year-old boy was admitted with the complaints of continuous fever, vomiting, abdominal pain, and bruise on leg. He looked pale and his physical examination revealed purpuric skin lesions on both legs. A mild hepatosplenomegaly was noted on palpation. Laboratory tests showed hematocrit 21%, hemoglobin 7 g/dL, platelet count 20,000/mm3, prothrombin time 19 seconds, activated partial thromboplastin time 48 seconds, plasma fibrinogen level 20 mg/dL, andd-dimer 8 µg/mL. Serum antibrucella titration agglutination test was found to be 1 of 1280 positive. Blood cultures performed on specimens obtained at the time of admission yielded Brucella melitensis. The clinical and laboratory findings were consistent with DIC.

Sign in / Sign up

Export Citation Format

Share Document