Granulomatous Interstitial Nephritis as the Presenting Manifestation of Crohn’s Disease: A Case Report and Review of Literature

The isolated appendiceal Crohn’s disease without preceding bowel symptoms is a rare phenomenon, especially in older patients. In this case report, we present a 60-year-old female with isolated appendiceal Crohn’s disease presenting with acute appendicitis. She presented with classical features of appendicitis with elevated inflammatory markers. She underwent an appendectomy which showed an excessively swollen, oedematous, and reddish appendix with swelling extending to the base of the caecum. Histological evaluation was suggestive of Crohn’s disease, and subsequent colonoscopy was unremarkable. Following appendectomy, she was asymptomatic without any recurrence of disease. The atypical morphological appearance of the appendix should raise suspicion of Crohn’s disease. This case highlights the importance of histopathological analysis of the specimen, especially in abnormal clinical findings. The prognosis of such patients seems to be good, and additional treatment is rarely needed.

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Granulomatous Interstitial Nephritis in Children Resulting from Wegener’s Granulomatosis, Crohn’s Disease, or Sarcoidosis

Sarcoidosis and Granulomatosis - Diagnosis and Management ◽

10.5772/intechopen.84491 ◽

2020 ◽

Author(s):

Galina Makovetskaya ◽

Lilia Mazur ◽

Elena Balashova

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Interstitial Nephritis ◽

Wegener’S Granulomatosis ◽

Wegener's Granulomatosis ◽

Granulomatous Interstitial Nephritis

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Multicentric Cutaneous Crohn's Disease: A Case Report and Review of Literature

Canadian Journal of Gastroenterology ◽

10.1155/1990/480817 ◽

1990 ◽

Vol 4 (2) ◽

pp. 59-63 ◽

Cited By ~ 2

Author(s):

Robert Prokopetz ◽

J Barrie Ross ◽

Peter Smith ◽

Joseph J Sidorov

Keyword(s):

Crohn’S Disease ◽

Case Report ◽

Crohn's Disease ◽

Erythema Nodosum ◽

Skin Lesions ◽

Review Of Literature ◽

Histological Features ◽

The Past ◽

Common Skin ◽

Skin Conditions

A patient presented with skin lesions at sites not contiguous with Crohn's disease of the bowel and with specific histological features of Crohn's disease occurring two weeks from the onset of bowel symptoms. Currently a number of nonspecific skin conditions such as erythema nodosum, pyoderma gangrenosum and erythema multiforme are accepted as being the most common skin manifestations of Crohn's disease. It is likely, however, that specific lesions of Crohn's disease in the skin have been underdiagnosed either because of lack of biopsy or misinterpretation of the histology. Twenty-three cases with specific Crohn's disease in the skin have been recorded in the past 25 years, since the condition has been recognized. Sarcoidosis has been a common misdiagnosis. The literature relating to multicentric Crohn's disease is reviewed and attention drawn to its protean and masquerading features. An argument is made for the use of the term 'multicentric' rather than 'metastatic' in relation to cutaneous Crohn's disease.

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