Role of the JAK2 V617F Mutation in Inflammatory Bowel Disease-associated Thromboembolism: Case Report and Review of the Literature

2017 ◽  
Vol 112 ◽  
pp. S1094-S1095
Author(s):  
Amir Rumman ◽  
Sarah Alghamdi
Keyword(s):  
Inflammatory Bowel Disease ◽  
Case Report ◽  
Bowel Disease ◽  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Review Of The Literature ◽  
Inflammatory Bowel ◽  
V617f Mutation

scholarly journals P155 THROMBOEMBOLISM IN INFLAMMATORY BOWEL DISEASE. IS THERE A ROLE FOR THE JAK2 V617F MUTATION?

2008 ◽  
Vol 2 (1) ◽  
pp. 51
Author(s):  
O. Karimi ◽  
I.E. Koutroubakis ◽  
A.M. Sambuelli ◽  
R. Heijmans ◽  
C. Coucoutsi ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Inflammatory Bowel ◽  
V617f Mutation

scholarly journals Monozygotic twins with Crohn’s disease and ulcerative colitis: a unique case report

Gut ◽  
1997 ◽  
Vol 41 (4) ◽  
pp. 557-560 ◽  
Author(s):  
N P Breslin ◽  
A Todd ◽  
C Kilgallen ◽  
C O’Morain
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Case Report ◽  
Crohn's Disease ◽  
Bowel Disease ◽  
Monozygotic Twins ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Environmental Agents ◽  
Inflammatory Bowel

Background—A large number of monozygotic and dizygotic twin pairs with inflammatory bowel disease have been reported. To date no twin pair has developed phenotypically discordant inflammatory bowel disease. This case report is the first documented occurrence of discordant inflammatory bowel disease occurring in monozygotic twins.Case report—Twenty two year old identical male twins presented within three months of each other with inflammatory bowel disease that proved to be discordant in overall disease type, disease distribution, clinical course, and histopathological findings. Twin 1 developed a severe pancolitis necessitating total colectomy while twin 2 developed a predominantly distal patchy colitis with frequent granulomas, controlled by aminosalicylates. Twin 1 was antineutrophil cytoplasmic antibody (ANCA) negative at the time of testing while twin 2 (Crohn’s disease) was ANCA positive. Significantly, the twins possessed the HLA type DR3-DR52-DQ2 previously associated with extensive colitis.Conclusion—This case report confirms the important role played by genetic factors in the development of inflammatory bowel disease. It also highlights the crucial role of undetermined environmental agents in dictating disease expression and phenotype.

scholarly journals Dining With Inflammatory Bowel Disease: A Review of the Literature on Diet in the Pathogenesis and Management of IBD

2019 ◽  
Author(s):  
Phillip Gu ◽  
Linda A Feagins
Keyword(s):  
Inflammatory Bowel Disease ◽  
Genetic Predisposition ◽  
Bowel Disease ◽  
Supply And Demand ◽  
Significant Proportion ◽  
Review Of The Literature ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Improving Patient Care

Abstract Inflammatory bowel diseases (IBDs) are chronic immune-related diseases hypothesized to be a sequela of an interplay of genetic predisposition and environmental exposures. The global incidence of IBD is increasing, and more patients are exploring diet as a means to explain and treat their IBD. In fact, many patients strongly believe diet plays a fundamental role in the onset and management of their IBD. However, a significant proportion of patients report limited nutritional education from their provider, and providers report limited nutritional resources to aid in discussions with patients. This imbalance between supply and demand likely reflects the previous paucity of available literature characterizing the influence of diet in IBD. To address this gap in knowledge, we review the available literature to characterize the role of diet in the pathogenesis, exacerbation, and treatment of IBD. We aim to provide patients and providers with resources to better understand and discuss the role of diet in IBD, with the overall goal of improving patient care and satisfaction.

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