scholarly journals S1379 Celiac Disease on the Rise in the U.S. Military Population: Epidemiology and Impact on Operational Readiness

2021 ◽  
Vol 116 (1) ◽  
pp. S633-S633
Author(s):  
Jared S. Magee ◽  
Rachel U. Lee
2019 ◽  
Vol 185 (5-6) ◽  
pp. e755-e758 ◽  
Author(s):  
Aditya Mehta ◽  
Donovan Reed ◽  
Kyle E Miller

Abstract Introduction Diplopia and strabismus are known complications after corneal refractive surgery (CRS). Within the U.S. Armed Forces, refractive surgery is used to improve the operational readiness of the service member, and these complications could cause significant degradation to their capability. This study was performed in order to identify the incidence of strabismus and diplopia following CRS within the U.S. Military Health System. Methods A retrospective review of all patients who underwent photorefractive keratectomy (PRK) or laser-assisted in situ keratomileusis (LASIK) in the Department of Defense from January 2006 through September 2013 was designed and approved by the Naval Medical Center Portsmouth Institutional Review Board. The military health system data mart was queried for all patients who underwent one of these procedures and subsequently had an International Classification of Disease-9 code for any strabismus or diplopia through 2014 allowing at least 1 year of follow-up. We then calculated the incidence of both diplopia and strabismus for these procedures as the primary measure and the overall prevalence as a secondary measure. Results A total of 108,157 patients underwent PRK or LASIK during our study period with 41 of these patients subsequently having a diagnosis of diplopia or strabismus. After chart review, 16 of these patients were excluded resulting in 25 patients for inclusion in either the strabismus (23 patients, 0.02%) or diplopia (3 patients, 0.003%) cohorts with one patient having both. Of the 23 patients with postoperative strabismus, 4 were new cases giving an incidence of 0.004% and 2 new cases of diplopia for an incidence of 0.002%. Conclusion Diplopia and strabismus are rare complications after CRS in the U.S. military population. These procedures continue to increase the operational readiness of our service members with minimal risk of these potentially debilitating complications. Overall, this study provides support for the continued use of PRK and LASIK despite study limitations related to the use of large databases for retrospective review. Future prospective studies using delineated preoperative and postoperative examinations with sensorimotor testing included may be able to resolve the limitations of this study.


Cureus ◽  
2020 ◽  
Author(s):  
John J Pisquiy ◽  
Jordan T Carter ◽  
Andrew Chan ◽  
Nicholas Kusnezov ◽  
Adam Adler

2017 ◽  
Vol 17 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Douglas Mogul ◽  
Yusuke Nakamura ◽  
Jaein Seo ◽  
Barri Blauvelt ◽  
John F P Bridges
Keyword(s):  

2019 ◽  
Vol 44 (6) ◽  
pp. 516.e1-516.e7 ◽  
Author(s):  
John J. Pisquiy ◽  
Andrew G. Chan ◽  
Gautham Prabhakar ◽  
Nicholas Kusnezov ◽  
John C. Dunn

1998 ◽  
Vol 114 ◽  
pp. A418
Author(s):  
S.N. Stavropoulos ◽  
P.H.R. Green ◽  
S.G. Panagi ◽  
S.L. Goldstein
Keyword(s):  

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 1631-1631
Author(s):  
Pawan K. Karanam ◽  
Mohammed Al-Hamadani ◽  
Stephen M Ansell ◽  
Ronald S. Go

Abstract Background: Enteropathy-associated T-cell lymphoma (EATL) is a very rare primary intestinal non-Hodgkin lymphoma (NHL) strongly associated with celiac disease. Previous studies suggest that EATL may be more common in Europe and among white population, in which celiac disease is a prevalent condition. However, comparative racial epidemiologic study of EATL in a large population is lacking and clinical studies remain limited to small series. Using two U.S. population databases, we determined the comparative incidences according to race and described the clinical features and outcome of the largest series of EATL reported to date. Methods: Incidence rates (case/1,000,000) were calculated using 2000-2010 data from the Surveillance, Epidemiology, and End Results (SEER) Program and age-adjusted to the U.S. 2000 standard population. Patient level data were obtained from the National Cancer Data Base (NCDB) Participant User File and analyzed for demographic patterns and stage distribution (1998-2011) as well as overall survival (1998-2006). SEER, a program of the U.S. National Cancer Institute, collects cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population. NCDB, a joint program of the American College of Surgeons and the American Cancer Society, is a nationwide oncology outcomes database for more than 1,500 cancer programs in the U.S. and Puerto Rico capturing about 70% of all newly diagnosed cases of cancer in the U.S. Results: In the years 2000-2010, the overall incidence rate of EATL in the U.S. population was 0.111. Asians/Pacific Islanders had a higher incidence rate (0.236) compared to other races (whites [0.101], blacks [0.107], American Indians/Alaska natives [0.128]). The risk ratio of Asians compared to non-Asians was 2.32 (95% CI: 1.39-3.69; P =0.002). From 1998-2011, 515,026 patients were diagnosed with NHL and 337 (0.07%) had EATL. The median age was 64 years (range, 20 -90+ years) and 60% of patients were males. The stage distribution was as follows: I (26.7%), II (16.3%), III (3.3%), IV (29.1%), and unknown (24.6%). The median overall survival (OS) for the entire cohort was 5.9 months. Patients diagnosed in the more recent era (2003-2006) had a better outcome (median OS, 6.6 versus 2.6 months; Figure 1; P = 0.034). Asians/Pacific Islanders had a worse outcome compared to other races (Figure 2; P = 0.031). Multivariable analysis showed the following to be independent factors associated with inferior OS: age >60 years (HR: 1.49; 95% CI: 1.05-2.10), Asians/Pacific Islanders (HR: 2.27; 95% CI: 1.08-4.76), stage III/IV (HR: 3.03; 95%CI: 2.00-4.59), and diagnosis before 2003 (HR: 1.59; 95%CI: 1.10-2.28). Conclusions: Contrary to previous studies, we find that the highest incidence and lowest survival rates of EATL occur among Asians/Pacific Islanders, populations in which celiac disease is not considered to be prevalent. The overall survival of EATL patients has improved over time but remains poor. Figure 1 Figure 1. Figure 2 Figure 2. Disclosures No relevant conflicts of interest to declare.


2019 ◽  
Vol 156 (6) ◽  
pp. S-135
Author(s):  
Aliki Taylor ◽  
Barbara H. Johnson ◽  
Katherine Cappell ◽  
Steve Gelwicks ◽  
Song Wang ◽  
...  

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