scholarly journals Modern aproaches to diabetic macular edema diagnosticks

2020 ◽  
Vol 23 (3) ◽  
pp. 260-266
Author(s):  
A. V. Doga ◽  
P. L. Volodin ◽  
E. V. Ivanova ◽  
D. A. Buryakov ◽  
O. I. Nikitin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Early Diagnosis ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Vision Loss ◽  
Diagnostic Methods ◽  
Diabetic Patients ◽  
Timely Treatment

Diabetic macular edema (DME) continues to be an important problem of modern ophthalmology and endocrinology. Therisk of edema is higher in patients with type 2 diabetes. Thus, this is the main cause of irreversible vision loss in these patients. DME is one of the prognostically unfavorable and difficult to treat manifestations of diabetic retinopathy. As themain cause of vision loss in diabetic patients, diabetic macular edema is often not diagnosed immediately, which causes difficulties in the treatment of pathology. Thus, early diagnosis and timely treatment of this disease is the key to successfully counteract the uncontrolled decline in the patients visual functions. In this article, the team of authors highlighted the possibilities of informative instrumental research methods available in the Arsenal of modern ophthalmological services. Based on the analysis of modern literature, the main principles of these diagnostic methods were indicated, their key capabilities and limitations compared to each other were highlighted. Knowledge of these characteristics is, in our opinion, an integral and most important tool in the Arsenal of a practicing ophthalmologist who supervises patients with this pathology.

scholarly journals Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Donato Santovito ◽  
Lisa Toto ◽  
Velia De Nardis ◽  
Pamela Marcantonio ◽  
Rossella D’Aloisio ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Vision Loss ◽  
External Validation ◽  
Diabetic Patients ◽  
Disease Biomarkers ◽  
Response To Stress ◽  
Severity Of The Disease ◽  
Plasma Microrna

AbstractDiabetic retinopathy (DR) is a leading cause of vision loss and disability. Effective management of DR depends on prompt treatment and would benefit from biomarkers for screening and pre-symptomatic detection of retinopathy in diabetic patients. MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression which are released in the bloodstream and may serve as biomarkers. Little is known on circulating miRNAs in patients with type 2 diabetes (T2DM) and DR. Here we show that DR is associated with higher circulating miR-25-3p (P = 0.004) and miR-320b (P = 0.011) and lower levels of miR-495-3p (P < 0.001) in a cohort of patients with T2DM with DR (n = 20), compared with diabetic subjects without DR (n = 10) and healthy individuals (n = 10). These associations persisted significant after adjustment for age, gender, and HbA1c. The circulating levels of these miRNAs correlated with severity of the disease and their concomitant evaluation showed high accuracy for identifying DR (AUROC = 0.93; P < 0.001). Gene ontology analysis of validated targets revealed enrichment in pathways such as regulation of metabolic process (P = 1.5 × 10–20), of cell response to stress (P = 1.9 × 10–14), and development of blood vessels (P = 2.7 × 10–14). Pending external validation, we anticipate that these miRNAs may serve as putative disease biomarkers and highlight novel molecular targets for improving care of patients with diabetic retinopathy.

scholarly journals Cribado de la retinopatía diabética en el primer nivel de atención usando retinografía en la Ciudad de México

2018 ◽  
Vol 16 (2) ◽  
pp. 11-19
Author(s):  
Daniel Paniagua Herrera ◽  
Consuelo González Salinas
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Primary Care ◽  
Type 2 Diabetes Mellitus ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Vision Loss ◽  
Tertiary Care ◽  
Number Of Patients

Objective:To determine the prevalence of diabetic retinopathy and diabetic macular edema by means of retinography in patients diagnosed with Type 2 diabetes mellitus according to time of evolution and degree of vision loss with and without refractive correction.Method: A descriptive cross-sectional study of 150 patients with Type 2 diabetes mellitus assessed in optometry in various health centers from the Sanitary Jurisdiction of Tlalpan, Health Services of Mexico City.Results: 150 patients (70% women, 30% men) aged 60 (+/– 7.77) were diagnosed with Type 2 diabetes mellitus, 52% of them with an evolution of 12.09 years (+/– 3.48). Of the total number of patients, 72.33% had retinopathy and/or diabetic macular edema lesions. The average visual acuity improved from 0.62 (+/– 0.48) to 0.37 (+/– 0.38) with refractive correction, absolute disability decreased by –18.76% and null or slight disability increased by 31.31%. Of the total population, 75.5% remained under monitoring in primary care, and 24.5% were referred to tertiary care in ophthalmology.Conclusion: The strategic opportunity to combat vision loss due to retinopathy and diabetic macular edema is found in its timely detection by health personnel trained in scrutiny and control at the primary care level, which would represent a decreased hospital load in tertiary care, thereby reducing costs for the health systems, as well as cost-efficiency for the years of sight gained and optimization of the patient’s global vision.

scholarly journals Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Yoo-Ri Chung ◽  
Sung Wook Park ◽  
Shin-Young Choi ◽  
Seung Woo Kim ◽  
Ka Young Moon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Statin Use

Clinical Diagnosis and New Classification of Diabetic Retinopathy and Diabetic Macular Edema

2018 ◽  
pp. 119-123
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Vision Loss ◽  
Diabetic Patients ◽  
Common Causes ◽  
Diagnosis Classification

Diabetic retinopathy and diabetic macular edema are the most common causes of preventable blindness among the working class in many countries. The prevalence of diabetic macular edema, which is frequently associated with vision loss, is increasing. Classification of diabetic retinopathy is essential for precise and punctual treatment and follow-up, and ultimately for enhancing the quality of life of diabetic patients. Studies in recent years have shared protocols for diagnosis, classification, and follow-up.

scholarly journals Bevacizumab and Treatment Regimes in Diabetic Retinopathy and Diabetic Macular Edema

2018 ◽  
pp. 155-159
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Proliferative Diabetic Retinopathy ◽  
Vision Loss ◽  
Intravitreal Bevacizumab ◽  
Retinal Neovascularization ◽  
Diabetic Patients ◽  
Treatment Regimes ◽  
Endothelial Growth Factor

Diabetic macular edema and proliferative diabetic retinopathy is the most important cause of vision loss in diabetic patients. Vascular endothelial growth factor has been shown to play a major role in retinal neovascularization and vascular hyperpermeability in eyes with diabetic patients. Recent studies have demonstrated the usefulness of an intravitreal injection of bevacizumab in the reduction of diabetic macular edema, vascular permeability, and fibrovascular proliferation in retinal neovascularization secondary to proliferative diabetic retinopathy. This review aimed to evaluate the intravitreal bevacizumab in diabetic retinopathy and diabetic macular edema.

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