scholarly journals The effect of multiple injections of cholecystokinin 26-33 on a - and p-cells of islets of Langerhans normal and in experimental type 1 diabetes mellitus

2004 ◽  
Vol 50 (3) ◽  
pp. 37-41
Author(s):  
M. A. Orlovskii ◽  
Yu. M. Kolesnik ◽  
A. V. Abramov
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Islets Of Langerhans ◽  
Cell Function ◽  
Central Administration ◽  
Routes Of Administration ◽  
Experimental Type ◽  
The Impact

The impact of multiple peripheral (intraperitoneal) and central (intracerebroventricular) administrations of cholecystokinin 26-33 (CCK-8) octapeptide on the function of a- and /3- cells of the islets of Langerhans was studied in investigations made on normal rats and rats with experimental streptosotocine-induced type 1 diabetes mellitus. Insulin in /З-cells and glucagon in а-cells were found by indirect immunofluorescence. Both routes of administration to normal animals were shown to lead to the suppressed secretion of insulin with decreased food intake. At the same time the central administration of CCK-8, unlike the peripheral one, caused a sig­nificant (p < 0.05) rise in the level of glycemia and enhanced glucagon production in а-cells, while the administrations of the peptide to diabetic animals resulted a significant increase in the blood concentration of insulin (p < 0.05), to the lower level of glycemia (p < 0.05) and to suppressed polyphagia (p < 0.01), which is associated with the activation of /З-cell function and with the suppression of the pathologically high activity of а-cells. The established facts suggest that neuroendocrine interactions are impaired in diabetes mellitus and confirm the previously made suggestions that cholecystokinin plays an important role in the pathogenesis of this disease.

scholarly journals The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels

2020 ◽  
Vol 67 (1) ◽  
pp. 59-71 ◽  
Author(s):  
Simona Hylmarova ◽  
Katerina Stechova ◽  
Gabriela Pavlinkova ◽  
Jana Peknicova ◽  
Milan Macek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Sex Hormone ◽  
Hormone Levels ◽  
The Impact

scholarly journals Cukorbeteg gyermekek együttműködésének vizsgálata a Diabetes Adherencia Kérdőív gyermekváltozatának validálása során

2019 ◽  
Vol 160 (29) ◽  
pp. 1136-1142
Author(s):  
Brigitta Munkácsi ◽  
Beáta Erika Nagy ◽  
Karolina Eszter Kovács
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Reliability Analysis ◽  
English Language ◽  
Target Level ◽  
Adolescent Population ◽  
The Impact

Abstract: Introduction: Most of the adolescents suffering from type 1 diabetes mellitus (T1DM) can be described with HbA1c values below the target level. Several research investigated the impact of diabetes on the quality of life, however, no complex questionnaire has been developed to examine each area of the disease. Aim: The aim of the present study is to create a Hungarian, reliable and valid questionnaire which can cover each aspect of the adherence related to type 1 diabetes mellitus. Method: In the present study, the attention was drawn to the introduction of a new questionnaire related to diabetes adherence which can be applied among children and adolescents as well. To test the questionnaire and to reduce the number of the items and to determine the scales, reliability analysis (Cronbach’s α) and factor analysis was applied. Results: The new measurement, which was created through the translation of English language international questionnaires, their pre-test, and its reduction by factor and reliability analysis, containing 9 subscales with 58 items, is stated as reliable regarding the results of the Cronbach’s α index. Conclusion: It can be stated that the created Diabetes Adherence Questionnaire can be reliably applied on child and adolescent population and it can be adapted for people suffering from other types of chronic diseases. Orv Hetil. 2019; 160(29): 1136–1142.

scholarly journals Factors determining insulin requirements in women with type 1 diabetes mellitus during pregnancy: a review

2014 ◽  
Vol 7 (2) ◽  
pp. 52-59 ◽  
Author(s):  
Naomi Achong ◽  
Harold David McIntyre ◽  
Leonie Callaway
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cell Function ◽  
Normal Pregnancy ◽  
Late Gestation ◽  
Premature Delivery ◽  
Insulin Requirements ◽  
In Pregnancy

Most women with type 1 diabetes mellitus (T1DM) have increased insulin requirements during pregnancy. However, a minority of women have a fall in insulin requirements. When this occurs in late gestation, it often provokes concern regarding possible compromise of the feto-placental unit. In some centres, this is considered as an indication for delivery, including premature delivery. There are, however, many other factors that affect insulin requirements in pregnancy in women with type 1 diabetes mellitus and the decline in insulin requirements may represent a variant of normal pregnancy. If there is no underlying pathological process, expedited delivery in these women is not warranted and confers increased risks to the newborn. We will explore the factors affecting insulin requirements in gestation in this review. We will also discuss some novel concepts regarding beta-cell function in pregnancy.

scholarly journals PDB96 THE IMPACT OF ADJUNCT DAPAGLIFLOZIN ON TREATMENT SATISFACTION IN TYPE 1 DIABETES MELLITUS

2019 ◽  
Vol 22 ◽  
pp. S590
Author(s):  
J. Gordon ◽  
L. Beresford-Hulme ◽  
H. Bennett ◽  
A. Tank ◽  
C. Edmonds ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Treatment Satisfaction ◽  
The Impact
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