The impact of type 1 diabetes mellitus on male sexual functions and sex hormone levels

Abstract: Introduction: Most of the adolescents suffering from type 1 diabetes mellitus (T1DM) can be described with HbA1c values below the target level. Several research investigated the impact of diabetes on the quality of life, however, no complex questionnaire has been developed to examine each area of the disease. Aim: The aim of the present study is to create a Hungarian, reliable and valid questionnaire which can cover each aspect of the adherence related to type 1 diabetes mellitus. Method: In the present study, the attention was drawn to the introduction of a new questionnaire related to diabetes adherence which can be applied among children and adolescents as well. To test the questionnaire and to reduce the number of the items and to determine the scales, reliability analysis (Cronbach’s α) and factor analysis was applied. Results: The new measurement, which was created through the translation of English language international questionnaires, their pre-test, and its reduction by factor and reliability analysis, containing 9 subscales with 58 items, is stated as reliable regarding the results of the Cronbach’s α index. Conclusion: It can be stated that the created Diabetes Adherence Questionnaire can be reliably applied on child and adolescent population and it can be adapted for people suffering from other types of chronic diseases. Orv Hetil. 2019; 160(29): 1136–1142.

Download Full-text

PDB96 THE IMPACT OF ADJUNCT DAPAGLIFLOZIN ON TREATMENT SATISFACTION IN TYPE 1 DIABETES MELLITUS

Value in Health ◽

10.1016/j.jval.2019.09.978 ◽

2019 ◽

Vol 22 ◽

pp. S590

Author(s):

J. Gordon ◽

L. Beresford-Hulme ◽

H. Bennett ◽

A. Tank ◽

C. Edmonds ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Treatment Satisfaction ◽

The Impact

Download Full-text

The Impact of Type 1 Diabetes Mellitus on Corneal Epithelial Nerve Morphology and the Corneal Epithelium

American Journal Of Pathology ◽

10.1016/j.ajpath.2014.06.016 ◽

2014 ◽

Vol 184 (10) ◽

pp. 2662-2670 ◽

Cited By ~ 39

Author(s):

Daniel Cai ◽

Meifang Zhu ◽

W. Matthew Petroll ◽

Vindhya Koppaka ◽

Danielle M. Robertson

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Corneal Epithelium ◽

Corneal Epithelial ◽

The Impact

Download Full-text

Agent-based modeling for the self-management of chronic diseases: An exploratory study

SIMULATION ◽

10.1177/0037549717712605 ◽

2017 ◽

Vol 93 (9) ◽

pp. 781-793 ◽

Cited By ~ 3

Author(s):

Sara Montagna ◽

Andrea Omicini

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Chronic Diseases ◽

Agent Based Modeling ◽

Self Management ◽

Agent Based ◽

Management Interventions ◽

The Impact

The impact of mobile technologies on healthcare is particularly evident in the case of self-management of chronic diseases, where they can decrease spending and improve life quality of patients. We propose the adoption of agent-based modeling and simulation techniques as built-in tools to dynamically monitor the state of patient health and provide recommendations for self-management. To demonstrate the feasibility of our proposal we focus on Type 1 diabetes mellitus as our case study, and provide simulation results where the dynamic evolution of signal parameters is shown in the case of healthy and Type 1 diabetes mellitus patients, focussing in particular on the beneficial effects that self-management interventions have on plasma glucose values.

Download Full-text

The Impact of Parental Bonding on Sexual Distress in Women with Type 1 Diabetes Mellitus

Journal of Sexual Medicine ◽

10.1111/j.1743-6109.2012.02969.x ◽

2013 ◽

Vol 10 (2) ◽

pp. 378-385 ◽

Cited By ~ 1

Author(s):

Alexandra Bargiota ◽

Konstantinos Dimitropoulos ◽

Odysseas Mouzas ◽

Michael Melekos ◽

Vassilios Tzortzis ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Parental Bonding ◽

Sexual Distress ◽

The Impact

Download Full-text

The effect of multiple injections of cholecystokinin 26-33 on a - and p-cells of islets of Langerhans normal and in experimental type 1 diabetes mellitus

Problems of Endocrinology ◽

10.14341/probl11424 ◽

2004 ◽

Vol 50 (3) ◽

pp. 37-41

Author(s):

M. A. Orlovskii ◽

Yu. M. Kolesnik ◽

A. V. Abramov

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Islets Of Langerhans ◽

Cell Function ◽

Central Administration ◽

Routes Of Administration ◽

Experimental Type ◽

The Impact

The impact of multiple peripheral (intraperitoneal) and central (intracerebroventricular) administrations of cholecystokinin 26-33 (CCK-8) octapeptide on the function of a- and /3- cells of the islets of Langerhans was studied in investigations made on normal rats and rats with experimental streptosotocine-induced type 1 diabetes mellitus. Insulin in /З-cells and glucagon in а-cells were found by indirect immunofluorescence. Both routes of administration to normal animals were shown to lead to the suppressed secretion of insulin with decreased food intake. At the same time the central administration of CCK-8, unlike the peripheral one, caused a significant (p < 0.05) rise in the level of glycemia and enhanced glucagon production in а-cells, while the administrations of the peptide to diabetic animals resulted a significant increase in the blood concentration of insulin (p < 0.05), to the lower level of glycemia (p < 0.05) and to suppressed polyphagia (p < 0.01), which is associated with the activation of /З-cell function and with the suppression of the pathologically high activity of а-cells. The established facts suggest that neuroendocrine interactions are impaired in diabetes mellitus and confirm the previously made suggestions that cholecystokinin plays an important role in the pathogenesis of this disease.

Download Full-text

Assessment of biomarkers of inflammation and premature atherosclerosis in adolescents with type-1 diabetes mellitus

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2018-0192 ◽

2019 ◽

Vol 32 (2) ◽

pp. 109-113 ◽

Cited By ~ 6

Author(s):

Ghufran Babar ◽

Mark Clements ◽

Hongying Dai ◽

Geetha Raghuveer

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type 1 Diabetes Mellitus ◽

Pearson Correlation ◽

Premature Coronary Artery Disease ◽

The Impact ◽

Early Atherosclerosis

Abstract Background Type-1 diabetes mellitus (T1DM) causes endothelial dysfunction and early atherosclerosis, which can result in premature coronary artery disease. The aim of this study was to determine the impact of glycemic control, vascular oxidative stress and inflammation on vascular health in adolescents with T1DM. Methods This was a cross-sectional study in adolescents with age- and sex-matched T1DM who were ≥12 years and were at least 2 years post-diagnosis. Recruitment was balanced to include individuals with hemoglobin A1c (HbA1c) ≤8.5% (n=27) or with HbA1c ≥9.5% (n=25). Biomarkers of inflammation were measured in the blood including C-reactive protein (CRP), interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), E-selectin, fibrinogen and tumor necrosis factor-α (TNF-α). Carotid intima media thickness (cIMT) and peripheral arterial tonometry (PAT) were assessed. Results Plasma E-selectin level was significantly different between the two groups with higher levels in the group with HbA1c ≥9.5% (65.0±27.7 ng/mL vs. 48.8±21.5 ng/mL, p=0.02). Though cIMT and PAT were not significantly different between the groups, Pearson correlation showed a significant direct relationship between rising HbA1c and mean right cIMT (p=0.02; r=0.37), PAT (p=0.03, r=0.31) and fibrinogen (p=0.03, r=0.03). Conclusions Elevated E-selectin level is an early marker of oxidative stress in T1DM patients with an elevated HbA1c level. Suboptimal glycemic control as evidenced by a rising HbA1c causes early atherosclerosis.

Download Full-text