scholarly journals The hypothalamo-hypophyseal system in patients with multinodular colloid euthyroid goiter

1994 ◽  
Vol 40 (3) ◽  
pp. 22-25
Author(s):  
A. D. Makarov ◽  
Yu. M. Keda ◽  
I. V. Kryukova ◽  
N. P. Goncharov ◽  
S. S. Pankova ◽  
...  
Keyword(s):  
Growth Factor ◽  
Clinical Diagnosis ◽  
Stage Iv ◽  
Thyrotropin Releasing Hormone ◽  
Test Results ◽  
Trh Test ◽  
Releasing Hormone ◽  
Clear Cut ◽  
Healthy Women

Eighty patients with multinodular colloidal euthyroid goiter were examined. Thyrotropin-releasing hormone (TRH) test was carried out in 22 patients and 7 healthy women. The results of the test indicate a clear-cut tendency to reduction of hypophyseal TTH reserve in patients with multinodular euthyroid goiter with enlarged thyroid. In other words, clinical diagnosis of an euthyroid condition in the examinees appears to be groundless, particularly in patients with stage IV multinodular euthyroid goiter who may be referred to latent hyperthyrosis group on the basis of TRH test results. Three types of STH reaction were revealed by TRH test in these patients. The authors put forward a hypothesis on STH contribution as a growth factor to the pathogenesis of multinodular colloid euthyroid goiter.

The thyrotropin-releasing hormone test: some statistical considerations

1992 ◽  
Vol 7 (1) ◽  
pp. 39-42
Author(s):  
CA de Mendonca Lima ◽  
S Vandel ◽  
P Bizouard
Keyword(s):  
Thyrotropin Releasing Hormone ◽  
Statistical Analyses ◽  
Test Interpretation ◽  
Test Results ◽  
Trh Test ◽  
Releasing Hormone ◽  
Administration Routes ◽  
Centre Hospitalier ◽  
Centre Hospitalier Universitaire ◽  
Sampling Times

SummaryFinal conclusions and data comparisons from the thyrotropin-releasing hormone (TRH) test results are made difficult by differences in test implementation methods, ie, TRH different administration routes, dosages and blood sampling times. A number of statistical analyses are feasible, which may also influence test interpretation. The authors review some types of statistical analyses and suggest using the area under curve (AUC) method as a means of evaluation. The TRH test was performed before treatment and after a 5-day wash-out period, in 40 depressed patients hospitalized in the Psychiatric Unit of Besancon Teaching Hospital (Centre Hospitalier Universitaire de Besançon). Variation analyses performed by peak and threshold comparison (7.0 IµU/ml) and by the AUC method (386 IµU/ml) in positive and negative patients revealed some statistical differences.

Thyrotropin-releasing hormone and epidermal growth factor induce human prolactin expression via identical multiple cis elements

1993 ◽  
Vol 92 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Monique Berwaer ◽  
Bernard Peers ◽  
Asuncion M. Nalda ◽  
Philippe Monget ◽  
Julian R.E. Davis ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Thyrotropin Releasing Hormone ◽  
Cis Elements ◽  
Releasing Hormone ◽  
Human Prolactin ◽  
Epidermal Growth
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