scholarly journals Influence of Anions and Cations on the Formation of Iron Oxide Nanoparticles in Aqueous Media

2022 ◽  
Author(s):  
Hidekazu Tanaka
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Aqueous Media ◽  
Oxide Nanoparticles ◽  
Anions And Cations

scholarly journals Iron Oxide Nanoparticles: Multiwall Carbon Nanotube Composite Materials for Batch or Chromatographic Biomolecule Separation

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Sebastian P. Schwaminger ◽  
Markus W. Brammen ◽  
Florian Zunhammer ◽  
Nicklas Däumler ◽  
Paula Fraga-García ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Composite Materials ◽  
Iron Oxide Nanoparticles ◽  
Aqueous Media ◽  
Industrial Applications ◽  
Oxide Nanoparticles ◽  
Multiwall Carbon Nanotube ◽  
Porous System ◽  
X Ray ◽  
Multiwall Carbon

AbstractCarbon-based materials are the spearhead of research in multiple fields of nanotechnology. Moreover, their role as stationary phase in chromatography is gaining relevance. We investigate a material consisting of multiwall carbon nanotubes (CNTs) and superparamagnetic iron oxide nanoparticles towards its use as a mixed-mode chromatography material. The idea is to immobilize the ion exchange material iron oxide on CNTs as a stable matrix for chromatography processes without a significant pressure drop. Iron oxide nanoparticles are synthesized and used to decorate the CNTs via a co-precipitation route. They bind to the walls of oxidized CNTs, thereby enabling to magnetically separate the composite material. This hybrid material is investigated with transmission electron microscopy, magnetometry, X-ray diffraction, X-ray photoelectron and Raman spectroscopy. Moreover, we determine its specific surface area and its wetting behavior. We also demonstrate its applicability as chromatography material for amino acid retention, describing the adsorption and desorption of different amino acids in a complex porous system surrounded by aqueous media. Thus, this material can be used as chromatographic matrix and as a magnetic batch adsorbent material due to the iron oxide nanoparticles. Our work contributes to current research on composite materials. Such materials are necessary for developing novel industrial applications or improving the performance of established processes.

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

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