scholarly journals Electrochemical Biosensors for Point of care Applications

2020 ◽  
Vol 70 (5) ◽  
pp. 549-556
Author(s):  
Chandran Karunakaran ◽  
Murugesan Karthikeyan ◽  
Marimuthu Dhinesh Kumar ◽  
Ganesan Kaniraja ◽  
Kalpana Bhargava
Keyword(s):  
Cytochrome C ◽  
Point Of Care ◽  
Electrochemical Determination ◽  
Analytical Tool ◽  
Electrochemical Biosensors ◽  
Biological Sensing ◽  
Sensing Element ◽  
Portable Biosensor

Biosensor refers to powerful and innovative analytical tool involving biological sensing element and transducer with broad range of applications, such as diagnosis, drug discovery, biomedicine, food safety and processing, environmental monitoring, security and defense. Recent advances in the field of biotechnology, microelectronics, and nanotechnology have improved the development of biosensors. Glucometers utilizing the electrochemical determination of oxygen or hydrogen peroxide employing immobilised glucose oxidase electrode seeded the discovery and development of biosensors. Molecular recognition based on geometry and forces of interaction play an important role in the biosensor development. The advent of nanotechnology led to highly efficient and sensitive biosensors. They also provide an effective immobilisation matrix for the various bioreceptors. Enzymatic and their mimetic (metalloporphyrin)-based biosensors for reactive oxygen, nitrogen species and cytochrome c will also be discussed. The role of antibodies and their applications in immunosensors development for cytochrome c and superoxide dismutase will be highlighted. The electrochemical biosensors are less expensive, miniaturised and used for point-of-care applications. Further, the fabrication of labVIEW based virtual biosensor instrumentation and microcontroller based portable biosensor for wide variety of applications also devices will be presented.

A complete lab-made point of care device for non-immunological electrochemical determination of cortisol levels in salivary samples

2021 ◽  
Vol 332 ◽  
pp. 129532
Author(s):  
A. Gevaerd ◽  
E.Y. Watanabe ◽  
C. Belli ◽  
L.H. Marcolino-Junior ◽  
M.F. Bergamini
Keyword(s):  
Point Of Care ◽  
Electrochemical Determination ◽  
Cortisol Levels

ELECTROCHEMICAL DNA SENSOR TECHNOLOGY FOR MONITORING OF DRUG–DNA INTERACTIONS

NANO ◽  
2008 ◽  
Vol 03 (04) ◽  
pp. 229-232 ◽  
Author(s):  
A. ERDEM ◽  
H. KARADENIZ ◽  
A. CALISKAN ◽  
A. VASEASHTA
Keyword(s):  
Drug Delivery ◽  
Small Molecules ◽  
Anticancer Drugs ◽  
Point Of Care ◽  
Sensor Technology ◽  
Electrochemical Biosensors ◽  
Dna Sensor ◽  
Dna Interactions ◽  
Electrochemical Dna Sensor

The objective of this investigation is to understand the nature and dynamics of binding small molecules to bio-macromolecules using electrochemical methods. The investigation pertaining to the design of site- and conformation-specific reagents provides a rationale for new studies of drug delivery design. Some anticancer drugs and DNA interactions have been undertaken by using a variety of techniques. Determination of interaction between DNA and DNA-targeted molecules would be valuable in the design of molecule-specific electrochemical biosensors for applications in diagnostics, development of drugs for chemotherapy, and as a biotechnological tool for DNA-based point-of-care diagnosis.

Über tagesperiodische Schwankungen der Sauerstoffbilanz kernhaltiger und kernloser Acetabularia mediterranea

1964 ◽  
Vol 19 (6) ◽  
pp. 499-505 ◽  
Author(s):  
E. Schweiger ◽  
H. G. Wallraff ◽  
H. G. Schweiger
Keyword(s):  
Diurnal Rhythm ◽  
Aquatic Organisms ◽  
Electrochemical Determination ◽  
Continuous Illumination ◽  
Oxygen Balance ◽  
Acetabularia Mediterranea

A method is described for the electrochemical determination of the oxygen balance of aquatic organisms. With this method it was possible to demonstrate that individual Acetabularia cells kept under continuous illumination showed a diurnal rhythm of photosynthesis for a period of several weeks. The rhythm could be observed even 40 days after removal of the nucleus. The role of the nucleus in this periodicity is discussed.

scholarly journals PERAN DOKTER SPESIALIS PATOLOGI KLINIK DALAM AKREDITASI RUMAH SAKIT (The Role For Clinical Pathologist in Hospital Accreditation)

2018 ◽  
Vol 21 (1) ◽  
pp. 102
Author(s):  
Anak Agung Wiradewi Lestari
Keyword(s):  
Quality Control ◽  
Point Of Care ◽  
Reference Value ◽  
Hospital Accreditation ◽  
Laboratory Equipment ◽  
Laboratory Service ◽  
Assessment Standard ◽  
Clinical Pathologist

The hospital accreditation of 2012 version assessment, performed through the evaluation of the implementation of hospitalaccreditation standards. It’s consisting of four (4) standards groups. The laboratory service is one component of the Assessment ofPatients (AOP) chapters. The role of Clinical Pathologist in this accreditation can be internal as well as external. In the laboratoryservices standard, there are 13 sections each with element of judgment. Some of the challenges are still encountered in the meeting forthe accreditation standards include the need for an agreement between the Clinical Pathologist and the Physician, perhaps even the roleof the Indonesian Association of Clinical Pathologist and Laboratory Medicine (IACPLM) to determine the values of which one has thecritical value, that should be reported by the laboratory to physician. In addition, most laboratories currently in Indonesia do not havea reference value corresponding to the population and geography. This would be the task of the specialist (us) together/IACPLM to beable to formulate the reference value or discuss it with the Hospital Accreditation Committee in order to obtain the same perception ofthe reference value. But considering the determination of the reference value is not a simple matter and this will require cost as well.Another challenge is controlling the laboratory equipment used in wards, such as Point of Care Testing (POCT) devices. Most POCTis used in wards is not provided by the laboratory. The hospitals should regularly receive reports and review the quality control of thereference laboratory. But so far, most of the reference laboratories do not report the results of quality control to the hospital laboratory.In one assessment standard, stated that the hospitals should have access to contact an expert of diagnostics specialist such concernedto parasitological, virological, or toxicological. The question is whether the Clinical Pathologist can not be regarded as an expert inparasitological and virological diagnostics?

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