scholarly journals Quantitative evaluation of the lumbosacral sagittal alignment in degenerative lumbar spinal stenosis

10.14444/2068 ◽  
2015 ◽  
Vol 9 ◽  
pp. 68 ◽  
Author(s):  
Serik K. Makirov ◽  
Andrew A. Yuz ◽  
Mohammed T. Jahaf ◽  
Anastasia A. Nikulina
Keyword(s):  
Spinal Stenosis ◽  
Quantitative Evaluation ◽  
Lumbar Spinal Stenosis ◽  
Sagittal Alignment ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal

scholarly journals The identification of novel gene mutations for degenerative lumbar spinal stenosis using whole-exome sequencing in a Chinese cohort

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Xin Jiang ◽  
Dong Chen
Keyword(s):  
Exome Sequencing ◽  
Whole Exome Sequencing ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Gene Mutations ◽  
Specific Gene ◽  
Single Nucleotide ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Whole Exome ◽  
Lumbar Spinal

Abstract Background Degenerative lumbar spinal stenosis (DLSS) is a common lumbar disease that requires surgery. Previous studies have indicated that genetic mutations are implicated in DLSS. However, studies on specific gene mutations are scarce. Whole-exome sequencing (WES) is a valuable research tool that identifies disease-causing genes and could become an effective strategy to investigate DLSS pathogenesis. Methods From January 2016 to December 2017, we recruited 50 unrelated patients with symptoms consistent with DLSS and 25 unrelated healthy controls. We conducted WES and exome data analysis to identify susceptible genes. Allele mutations firstly identified potential DLSS variants in controls to the patients’ group. We conducted a site-based association analysis to identify pathogenic variants using PolyPhen2, SIFT, Mutation Taster, Combined Annotation Dependent Depletion, and Phenolyzer algorithms. Potential variants were further confirmed using manual curation and validated using Sanger sequencing. Results In this cohort, the major classification variant was missense_mutation, the major variant type was single nucleotide polymorphism (SNP), and the major single nucleotide variation was C > T. Multiple SNPs in 34 genes were identified when filtered allele mutations in controls to retain only patient mutations. Pathway enrichment analyses revealed that mutated genes were mainly enriched for immune response-related signaling pathways. Using the Novegene database, site-based associations revealed several novel variants, including HLA-DRB1, PARK2, ACTR8, AOAH, BCORL1, MKRN2, NRG4, NUP205 genes, etc., were DLSS related. Conclusions Our study revealed that deleterious mutations in several genes might contribute to DLSS etiology. By screening and confirming susceptibility genes using WES, we provided more information on disease pathogenesis. Further WES studies incorporating larger DLSS patient cohorts are required to comprehend the genetic landscape of DLSS pathophysiology fully.

scholarly journals Severity of degenerative lumbar spinal stenosis affects pelvic rigidity during walking

2020 ◽  
Vol 20 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Helen Bumann ◽  
Corina Nüesch ◽  
Stefan Loske ◽  
S. Kimberly Byrnes ◽  
Balázs Kovacs ◽  
...  
Keyword(s):  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal

Computed tomography in degenerative lumbar spinal stenosis: The value of multiplanar reconstruction

Radiographics ◽  
1982 ◽  
Vol 2 (4) ◽  
pp. 529-551 ◽  
Author(s):  
Paul C. McAfee ◽  
Christopher G. Ullrich ◽  
E. Mark Levinsohn ◽  
Hansen A. Yuan ◽  
Edwin D. Cacayorin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Multiplanar Reconstruction ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal

scholarly journals Selection of Surgical Methods in Degenerative Lumbar Spinal Stenosis

1995 ◽  
Vol 9 (0) ◽  
pp. 55-63
Author(s):  
Tetsuya Morimoto ◽  
Tomonori Yamada ◽  
Hidemori Tokunaga ◽  
Toshio Kakizaki ◽  
Hidehiro Hirabayashi ◽  
...  
Keyword(s):  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Surgical Methods ◽  
Lumbar Spinal ◽  
Selection Of

scholarly journals Comparative Analysis of Non-Full and Full Endoscopic Spine Technique via Interlaminar Approach for the Treatment of Degenerative Lumbar Spinal Stenosis: A Retrospective, Single Institute, Propensity Score-Matched Study

2021 ◽  
pp. 219256822110391
Author(s):  
Qiang Jiang ◽  
Yu Ding ◽  
Zhengcao Lu ◽  
Hongpeng Cui ◽  
Jianjun Zhang ◽  
...  
Keyword(s):  
Propensity Score ◽  
Radiation Exposure ◽  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Clinical Efficacy ◽  
Operation Time ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Interlaminar Approach ◽  
Intraoperative Fluoroscopy ◽  
Lumbar Spinal

Study Design: Retrospective study. Objective: To compare the clinical efficacy of posterior lumbar laminectomy decompression under full endoscopic technique (Endo-LOVE) and percutaneous endoscopic medial foraminal decompression (PE-MFD) in the treatment of degenerative lumbar spinal stenosis (DLSS). Methods: Between April 2017 and April 2018, 96 patients with DLSS underwent Endo-LOVE or PE-MFD, including 58 with Endo-LOVE and 38 with PE-MFD. After propensity score matching (PSM), patient characteristics, operation time, intraoperative fluoroscopy times, postoperative bedridden time, hospital stay and postoperative complications were recorded and compared. The clinical efficacy was evaluated according to Oswestry disability index (ODI), visual analogue scale (VAS), lumbar disease JOA and modified MacNab criteria. Results: A total of 96 patients with DLSS were included in the study. After PSM, the 2 groups were comparable in patient demographic and baseline characteristics. The operation time and intraoperative fluoroscopy times in PE-MFD group were significantly more than those in Endo-LOVE group ( P < .05). The operation time in PE-MFD group was significantly less than that in Endo-LOVE group ( P < .05). The intraoperative fluoroscopy times in PE-MFD group were significantly more than that in Endo-LOVE group ( P < .05). The ODI, VAS and lumbar disease JOA in the 2 groups were significantly improved comparing with those before operation ( P < .05). According to the modified MacNab criteria, the excellent and good rates of the 2 groups were 93.5% in Endo-LOVE group and 87.1% in PE-MFD group ( P > .05). Conclusion: Endo-LOVE and PE-MFD technique can both effectively treat DLSS, and the short-term follow-up results are positive. Endo-LOVE technique has the advantages of fast puncture positioning, less radiation exposure and wider indications. However, PE-MFD needs more radiation exposure and has the possibility of incomplete decompression for complex multiplanar spinal stenosis.

Redundant Nerve Roots in Patients with Degenerative Lumbar Spinal Stenosis

1991 ◽  
Vol 26 (4) ◽  
pp. 1226
Author(s):  
Won Sik Choy ◽  
Sung Soo Joh ◽  
Chang Hyun Baik ◽  
Hyun Jin Jang
Keyword(s):  
Spinal Stenosis ◽  
Lumbar Spinal Stenosis ◽  
Nerve Roots ◽  
Degenerative Lumbar Spinal Stenosis ◽  
Lumbar Spinal
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