scholarly journals Predictive Factors of Residual Metastatic Axillary Lymph Nodes after Neoadjuvant Chemotherapy in Node-Positive Breast Cancer

2016 ◽  
Vol 4 (2) ◽  
pp. 42-47
Author(s):  
Han Young Lee ◽  
Ho Yong Park ◽  
Jin Gu Kang
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Predictive Factors ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Positive ◽  
Positive Breast Cancer

scholarly journals Level III axillary lymph nodes involvement in node positive breast cancer received neoadjuvant chemotherapy

The Breast ◽  
2013 ◽  
Vol 22 (6) ◽  
pp. 1161-1165 ◽  
Author(s):  
Zhaoqing Fan ◽  
Jinfeng Li ◽  
Tianfeng Wang ◽  
Yuntao Xie ◽  
Tie Fan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Positive ◽  
Positive Breast Cancer

scholarly journals Fat-enlarged axillary lymph nodes are associated with node-positive breast cancer in obese patients

2021 ◽  
Author(s):  
Roberta M. diFlorio-Alexander ◽  
Qingyuan Song ◽  
Dennis Dwan ◽  
Judith A. Austin-Strohbehn ◽  
Kristen E. Muller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Invasive Breast Cancer ◽  
Breast Mri ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Obese Women ◽  
Axillary Metastases ◽  
Node Positive ◽  
Positive Breast Cancer

Abstract Purpose Obesity associated fat infiltration of organ systems is accompanied by organ dysfunction and poor cancer outcomes. Obese women demonstrate variable degrees of fat infiltration of axillary lymph nodes (LNs), and they are at increased risk for node-positive breast cancer. However, the relationship between enlarged axillary nodes and axillary metastases has not been investigated. The purpose of this study is to evaluate the association between axillary metastases and fat-enlarged axillary nodes visualized on mammograms and breast MRI in obese women with a diagnosis of invasive breast cancer. Methods This retrospective case–control study included 431 patients with histologically confirmed invasive breast cancer. The primary analysis of this study included 306 patients with pre-treatment and pre-operative breast MRI and body mass index (BMI) > 30 (201 node-positive cases and 105 randomly selected node-negative controls) diagnosed with invasive breast cancer between April 1, 2011, and March 1, 2020. The largest visible LN was measured in the axilla contralateral to the known breast cancer on breast MRI. Multivariate logistic regression models were used to assess the association between node-positive status and LN size adjusting for age, BMI, tumor size, tumor grade, tumor subtype, and lymphovascular invasion. Results A strong likelihood of node-positive breast cancer was observed among obese women with fat-expanded lymph nodes (adjusted OR for the 4th vs. 1st quartile for contralateral LN size on MRI: 9.70; 95% CI 4.26, 23.50; p < 0.001). The receiver operating characteristic curve for size of fat-enlarged nodes in the contralateral axilla identified on breast MRI had an area under the curve of 0.72 for predicting axillary metastasis, and this increased to 0.77 when combined with patient and tumor characteristics. Conclusion Fat expansion of axillary lymph nodes was associated with a high likelihood of axillary metastases in obese women with invasive breast cancer independent of BMI and tumor characteristics.

scholarly journals Fat-enlarged Axillary Lymph Nodes are Associated with Node-Positive Breast Cancer in Obese Patients

2021 ◽  
Author(s):  
Roberta M. diFlorio-Alexander ◽  
Qingyuan Song ◽  
Dennis Dwan ◽  
Judith A. Austin-Strohbehn ◽  
Kristen E. Muller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Invasive Breast Cancer ◽  
Breast Mri ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Obese Women ◽  
Axillary Metastases ◽  
Node Positive ◽  
Positive Breast Cancer

AbstractPurposeObesity-associated fat infiltration of organ systems is accompanied by organ dysfunction and poor cancer outcomes. Obese women demonstrate variable degrees of fat infiltration of axillary lymph nodes (LNs), and they are at increased risk for node-positive breast cancer. However, the relationship between enlarged axillary nodes and axillary metastases has not been investigated. The purpose of this study is to evaluate the association between axillary metastases and fat-enlarged axillary nodes visualized on mammograms and breast MRI in obese women with a diagnosis of invasive breast cancer.MethodsThis retrospective case-control study included 431 patients with histologically confirmed invasive breast cancer. The primary analysis of this study included 306 patients with pre-operative MRI and body mass index (BMI) > 30 (201 node-positive cases and 105 randomly selected node-negative controls) diagnosed with invasive breast cancer diagnosed between April 1, 2011, and March 1, 2020. The largest visible LN was measured in the axilla contralateral to the known breast cancer on breast MRI. Multivariate logistic regression models were used to assess the association between node-positive status and LN size adjusting for age, BMI, tumor size, tumor grade, tumor subtype, and lymphovascular invasion.ResultsA strong likelihood of node-positive breast cancer was observed among obese women with fat-expanded lymph nodes (adjusted OR for the 4th vs. 1st quartile for contralateral LN size on MRI: 9.70; 95% CI: 4.26, 23.50; p < 0.001). The receiver operating characteristic curve for size of fat-enlarged nodes in the contralateral axilla identified on breast MRI had an area under the curve of 0.72 for predicting node-positive breast cancer and this increased to 0.80 when combined with patient and tumor characteristics.ConclusionFat expansion of axillary lymph nodes was associated with a high likelihood of axillary metastases in obese women with invasive breast cancer independent of BMI and tumor characteristics.

A Model to Predict Pathologic Complete Response of Axillary Lymph Nodes to Neoadjuvant Chemo(Immuno)Therapy in Patients With Clinically Node-Positive Breast Cancer

2014 ◽  
Vol 14 (5) ◽  
pp. 315-322 ◽  
Author(s):  
Robert-Jan Schipper ◽  
Martine Moossdorff ◽  
Patty J. Nelemans ◽  
Grard A.P. Nieuwenhuijzen ◽  
Bart de Vries ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Pathologic Complete Response ◽  
Complete Response ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Positive ◽  
Clinically Node Positive ◽  
Positive Breast Cancer

Pathological response in axillary lymph nodes after neo adjuvant chemotherapy in node positive breast cancer

2021 ◽  
Vol 47 (1) ◽  
pp. e10
Author(s):  
Afroza Sharmin ◽  
Anupama Nagarajakumar ◽  
Azhar Alani ◽  
Aliaa Shamardal ◽  
Sudeendra Doddi
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Pathological Response ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Positive ◽  
Neo Adjuvant Chemotherapy ◽  
Positive Breast Cancer

CT-Guided Wire Localization for Involved Axillary Lymph Nodes After Neo-adjuvant Chemotherapy in Patients With Initially Node-Positive Breast Cancer

2016 ◽  
Vol 22 (4) ◽  
pp. 390-396 ◽  
Author(s):  
Long Trinh ◽  
Kanae K. Miyake ◽  
Frederick M. Dirbas ◽  
Nishita Kothary ◽  
Kathleen C. Horst ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Wire Localization ◽  
Ct Guided ◽  
Node Positive ◽  
Neo Adjuvant Chemotherapy ◽  
Positive Breast Cancer

scholarly journals Predicting Four or More Metastatic Axillary Lymph Nodes in Patients with Sentinel Node-Positive Breast Cancer: Assessment of Existent Risk Scores

2010 ◽  
Vol 17 (11) ◽  
pp. 2884-2891
Author(s):  
Benjamin Zendejas ◽  
Tanya L. Hoskin ◽  
Amy C. Degnim ◽  
Carol A. Reynolds ◽  
David R. Farley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Sentinel Node ◽  
Risk Scores ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Node Positive ◽  
Positive Breast Cancer
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