scholarly journals Long-Term Results in Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine

1997 ◽  
Vol 40 (2) ◽  
pp. 41-45
Author(s):  
Ladislav Chrobák ◽  
Pavel Žák ◽  
Karel Podzimek ◽  
Lenka Plíšková ◽  
Jaroslava Foglová ◽  
...  
Keyword(s):  
Hairy Cell Leukemia ◽  
Interleukin 2 ◽  
Tumor Burden ◽  
Long Term Results ◽  
Mediastinal Lymphadenopathy ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Non Invasive ◽  
Previously Treated ◽  
Soluble Interleukin 2 Receptor

We treated 19 patients with hairy cell leukemia (HCL) with 2-chlorodeoxyadenosine. 15 patients followed up at least 6 months were evaluated. The follow up period varied between 6 months and 37 months (median, 19 months). 8 patients were previously treated. The overall response in 15 evaluable HCL patients was 100 %, with 87 % complete hematological remissions including three patients with retroperitoneal and mediastinal lymphadenopathy and one patient with leukemic infiltrates of the cornea; 13 % of patients achieved partial hematological remission. Soluble interleukin - 2 receptor (sIL-2R) considered as a reliable non-invasive marker of HCL tumor burden dropped from the median of 1350 pM/ml (range 188 to 9000 pM/ml) to the median of 84.3 pM/ml (range 37 to 382 pM/ml) RdW which reflects the anisocytosis of red cells decreased after therapy from the median of 20.6 % (range 13.1-25.0 %) to the median of 13.7 % (range 12.4-16.3 %).

Serum Soluble Interleukin-2 Receptor Levels in Hairy Cell Leukemia: Correlation with Clinical and Hematological Parameters and with α-Interferon Treatment

1992 ◽  
Vol 7 (1-2) ◽  
pp. 103-107 ◽  
Author(s):  
Francesco Lauria ◽  
Damiano Rondelli ◽  
Donatella Raspadori ◽  
Pier Luigi Zinzani ◽  
Donatella Benfenati ◽  
...  
Keyword(s):  
Hairy Cell Leukemia ◽  
Hematological Parameters ◽  
Interleukin 2 ◽  
Interferon Treatment ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor

scholarly journals Serum interleukin-2 receptor as index of tumor burden in hairy cell leukemia [letter; comment]

Blood ◽  
1991 ◽  
Vol 77 (11) ◽  
pp. 2540-2542 ◽  
Author(s):  
G Pizzolo ◽  
A Ambrosetti ◽  
F Vinante ◽  
M Chilosi ◽  
G Semenzato
Keyword(s):  
Hairy Cell Leukemia ◽  
Interleukin 2 ◽  
Tumor Burden ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Letter Comment

Soluble interleukin-2 receptor in hairy-cell leukemia: a reliable marker of disease

1993 ◽  
Vol 23 (1-4) ◽  
pp. 34-37 ◽  
Author(s):  
Achille Ambrosetti ◽  
Gianpaolo Nadali ◽  
Fabrizio Vinante ◽  
Maria Maddalena Ricetti ◽  
Giuseppe Todeschini ◽  
...  
Keyword(s):  
Hairy Cell Leukemia ◽  
Interleukin 2 ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor ◽  
Reliable Marker

High Serum Levels of Soluble Interleukin-2 Receptor and Absence of Detectable Levels of Soluble CD30 Molecule: A Specific Diagnostic Combination for Hairy Cell Leukemia

1992 ◽  
Vol 6 (4-5) ◽  
pp. 385-388 ◽  
Author(s):  
Giovanni Pizzolo ◽  
Friederike Dallenbach ◽  
Fabrizio Vinante ◽  
Lorella Morosato ◽  
Donata De Sabata ◽  
...  
Keyword(s):  
Hairy Cell Leukemia ◽  
Interleukin 2 ◽  
Serum Levels ◽  
High Serum ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Soluble Cd30 ◽  
Soluble Interleukin 2 Receptor

scholarly journals Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes

Blood ◽  
1989 ◽  
Vol 73 (8) ◽  
pp. 2128-2132 ◽  
Author(s):  
DM Komp ◽  
J McNamara ◽  
P Buckley
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Hairy Cell Leukemia ◽  
Poor Prognosis ◽  
Lymphoblastic Leukemia ◽  
Interleukin 2 ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor

The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.

scholarly journals Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes

Blood ◽  
1989 ◽  
Vol 73 (8) ◽  
pp. 2128-2132 ◽  
Author(s):  
DM Komp ◽  
J McNamara ◽  
P Buckley
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Hairy Cell Leukemia ◽  
Poor Prognosis ◽  
Lymphoblastic Leukemia ◽  
Interleukin 2 ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor

Abstract The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.

scholarly journals Serum interleukin-2 receptor as index of tumor burden in hairy cell leukemia [letter; comment]

Blood ◽  
1991 ◽  
Vol 77 (11) ◽  
pp. 2540-2542
Author(s):  
G Pizzolo ◽  
A Ambrosetti ◽  
F Vinante ◽  
M Chilosi ◽  
G Semenzato
Keyword(s):  
Hairy Cell Leukemia ◽  
Interleukin 2 ◽  
Tumor Burden ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Interleukin 2 Receptor ◽  
Letter Comment

Pentostatin in the treatment of advanced hairy cell leukemia.

1989 ◽  
Vol 7 (2) ◽  
pp. 168-172 ◽  
Author(s):  
E H Kraut ◽  
B A Bouroncle ◽  
M R Grever
Keyword(s):  
Hairy Cell Leukemia ◽  
Low Dose ◽  
Potent Inhibitor ◽  
Average Duration ◽  
Single Agent ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Previously Treated ◽  
The One ◽  
Marked Splenomegaly

2'-Deoxycoformycin (pentostatin [dCF]), a potent inhibitor of adenosine deaminase (ADA), was administered in a biweekly low-dose (2 to 4 mg/m2) intravenous (IV) schedule to patients with advanced hairy cell leukemia. Twenty-three patients were treated, including 12 patients previously treated by splenectomy and five patients treated with interferon. Twenty-one of 23 patients had objective responses, including 20 who achieved a complete remission (CR). Responses occurred rapidly, with an average time to CR of 5.4 months. Treatment was not continued once CR was achieved, and 15 of 20 patients remain in remission with an average duration of 12.6 months. CRs were achieved in both patients previously treated with interferon (three of five) and patients with marked splenomegaly (three of three). Relapses, when seen, have occurred in the bone marrow alone and the one patient who required retreatment was reinduced into CR. Toxicity has been mild and reversible, with nausea and vomiting, conjunctivitis, and skin rash as the main complications of treatment. dCF is the most effective single agent in the treatment of hairy cell leukemia, inducing a high percentage of CRs in all subgroups. Two multiinstitutional trials are now underway to compare its effectiveness v alpha interferon.

scholarly journals Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia

Blood ◽  
1988 ◽  
Vol 71 (5) ◽  
pp. 1304-1309 ◽  
Author(s):  
RG Steis ◽  
L Marcon ◽  
J Clark ◽  
W Urba ◽  
DL Longo ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Interferon Alpha ◽  
Hairy Cell Leukemia ◽  
Interleukin 2 ◽  
Response To Therapy ◽  
Soluble Form ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Activated T Cells ◽  
Recombinant Interferon

Abstract Activated T cells synthesize and express a cell membrane-bound receptor for interleukin-2 (IL-2) and have recently been shown to secrete a soluble form of the same receptor. Hairy cell leukemia is a chronic disorder caused by expansion of a clonal population of an unusual mononuclear cell of B cell origin. These cells have previously been shown to express an IL-2 receptor on the cell membrane. The sera of 26 patients with hairy cell leukemia were examined for the presence of a soluble IL-2 receptor before and during therapy with either recombinant interferon alpha-2a or 2′-deoxycoformycin. Before therapy, all patients had markedly elevated levels of this soluble IL-2 receptor ranging from five to 60 times the highest level observed in normal control sera. In individual patients changes in the level during therapy correlated well with clinical assessments of tumor response; levels fell to near the normal range in patients responding to therapy. Patients not responding to interferon alpha had no significant change in the soluble IL-2 receptor level. These results suggest that hairy cells secrete a soluble IL-2 receptor and that serial measurements of the level of this receptor in the serum can be used as a noninvasive means to assess disease response to therapy.

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