High Serum Levels of Soluble Interleukin-2 Receptor and Absence of Detectable Levels of Soluble CD30 Molecule: A Specific Diagnostic Combination for Hairy Cell Leukemia

The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.

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Elevated soluble interleukin-2 receptor in childhood hemophagocytic histiocytic syndromes

Blood ◽

10.1182/blood.v73.8.2128.2128 ◽

1989 ◽

Vol 73 (8) ◽

pp. 2128-2132 ◽

Cited By ~ 143

Author(s):

DM Komp ◽

J McNamara ◽

P Buckley

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Hairy Cell Leukemia ◽

Poor Prognosis ◽

Lymphoblastic Leukemia ◽

Interleukin 2 ◽

Hairy Cell ◽

Cell Leukemia ◽

Adult T Cell Leukemia ◽

Interleukin 2 Receptor ◽

Soluble Interleukin 2 Receptor

Abstract The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.

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Serum interleukin-2 receptor as index of tumor burden in hairy cell leukemia [letter; comment]

Blood ◽

10.1182/blood.v77.11.2540.2540 ◽

1991 ◽

Vol 77 (11) ◽

pp. 2540-2542 ◽

Cited By ~ 2

Author(s):

G Pizzolo ◽

A Ambrosetti ◽

F Vinante ◽

M Chilosi ◽

G Semenzato

Keyword(s):

Hairy Cell Leukemia ◽

Interleukin 2 ◽

Tumor Burden ◽

Hairy Cell ◽

Cell Leukemia ◽

Interleukin 2 Receptor ◽

Letter Comment

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Long-Term Results in Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2020.42 ◽

1997 ◽

Vol 40 (2) ◽

pp. 41-45

Author(s):

Ladislav Chrobák ◽

Pavel Žák ◽

Karel Podzimek ◽

Lenka Plíšková ◽

Jaroslava Foglová ◽

...

Keyword(s):

Hairy Cell Leukemia ◽

Interleukin 2 ◽

Tumor Burden ◽

Long Term Results ◽

Mediastinal Lymphadenopathy ◽

Hairy Cell ◽

Cell Leukemia ◽

Non Invasive ◽

Previously Treated ◽

Soluble Interleukin 2 Receptor

We treated 19 patients with hairy cell leukemia (HCL) with 2-chlorodeoxyadenosine. 15 patients followed up at least 6 months were evaluated. The follow up period varied between 6 months and 37 months (median, 19 months). 8 patients were previously treated. The overall response in 15 evaluable HCL patients was 100 %, with 87 % complete hematological remissions including three patients with retroperitoneal and mediastinal lymphadenopathy and one patient with leukemic infiltrates of the cornea; 13 % of patients achieved partial hematological remission. Soluble interleukin - 2 receptor (sIL-2R) considered as a reliable non-invasive marker of HCL tumor burden dropped from the median of 1350 pM/ml (range 188 to 9000 pM/ml) to the median of 84.3 pM/ml (range 37 to 382 pM/ml) RdW which reflects the anisocytosis of red cells decreased after therapy from the median of 20.6 % (range 13.1-25.0 %) to the median of 13.7 % (range 12.4-16.3 %).

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