scholarly journals Blood flow restriction prevents muscle damage but not protein synthesis signaling following eccentric contractions

2015 ◽  
Vol 3 (7) ◽  
pp. e12449 ◽  
Author(s):  
Mizuki Sudo ◽  
Soichi Ando ◽  
David C. Poole ◽  
Yutaka Kano
Keyword(s):  
Blood Flow ◽  
Protein Synthesis ◽  
Muscle Damage ◽  
Blood Flow Restriction ◽  
Eccentric Contractions ◽  
Flow Restriction

Muscle damage after low-intensity eccentric contractions with blood flow restriction

2014 ◽  
Vol 101 (2) ◽  
pp. 150-157 ◽  
Author(s):  
Robert Thiebaud ◽  
J.P. Loenneke ◽  
C.A. Fahs ◽  
D. Kim ◽  
X. Ye ◽  
...  
Keyword(s):  
Blood Flow ◽  
Muscle Damage ◽  
Blood Flow Restriction ◽  
Eccentric Contractions ◽  
Flow Restriction ◽  
Low Intensity

Does a resistance exercise session with continuous or intermittent blood flow restriction promote muscle damage and increase oxidative stress?

2017 ◽  
Vol 36 (1) ◽  
pp. 104-110 ◽  
Author(s):  
Gabriel R. Neto ◽  
Jefferson S. Novaes ◽  
Verônica P. Salerno ◽  
Michel M. Gonçalves ◽  
Gilmário R. Batista ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Flow ◽  
Resistance Exercise ◽  
Muscle Damage ◽  
Blood Flow Restriction ◽  
Exercise Session ◽  
Flow Restriction ◽  
Resistance Exercise Session

scholarly journals Blood Flow Restriction Combined With Low-load Resistance-type Exercise Increases Myofibrillar Protein Synthesis Rates

2018 ◽  
Vol 50 (5S) ◽  
pp. 645-646
Author(s):  
Jean Nyakayiru ◽  
Cas J. Fuchs ◽  
Joey S.J. Smeets ◽  
Annemie P. Gijsen ◽  
Joy P.B. Goessens ◽  
...  
Keyword(s):  
Blood Flow ◽  
Protein Synthesis ◽  
Load Resistance ◽  
Myofibrillar Protein ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Low Load ◽  
Myofibrillar Protein Synthesis

scholarly journals Blood Flow Restriction Only Increases Myofibrillar Protein Synthesis with Exercise

2019 ◽  
Vol 51 (6) ◽  
pp. 1137-1145 ◽  
Author(s):  
JEAN NYAKAYIRU ◽  
CAS J. FUCHS ◽  
JORN TROMMELEN ◽  
JOEY S. J. SMEETS ◽  
JOAN M. SENDEN ◽  
...  
Keyword(s):  
Blood Flow ◽  
Protein Synthesis ◽  
Myofibrillar Protein ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Myofibrillar Protein Synthesis

scholarly journals Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise

2012 ◽  
Vol 112 (9) ◽  
pp. 1520-1528 ◽  
Author(s):  
David M. Gundermann ◽  
Christopher S. Fry ◽  
Jared M. Dickinson ◽  
Dillon K. Walker ◽  
Kyle L. Timmerman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Protein Synthesis ◽  
Resistance Exercise ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Reactive Hyperemia ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Low Intensity ◽  
Mtorc1 Signaling

Blood flow restriction (BFR) to contracting skeletal muscle during low-intensity resistance exercise training increases muscle strength and size in humans. However, the mechanism(s) underlying these effects are largely unknown. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis (MPS) are stimulated following an acute bout of BFR exercise. The purpose of this study was to test the hypothesis that reactive hyperemia is the mechanism responsible for stimulating mTORC1 signaling and MPS following BFR exercise. Six young men (24 ± 2 yr) were used in a randomized crossover study consisting of two exercise trials: low-intensity resistance exercise with BFR (BFR trial) and low-intensity resistance exercise with sodium nitroprusside (SNP), a pharmacological vasodilator infusion into the femoral artery immediately after exercise to simulate the reactive hyperemia response after BFR exercise (SNP trial). Postexercise mixed-muscle fractional synthetic rate from the vastus lateralis increased by 49% in the BFR trial ( P < 0.05) with no change in the SNP trial ( P > 0.05). BFR exercise increased the phosphorylation of mTOR, S6 kinase 1, ribosomal protein S6, ERK1/2, and Mnk1-interacting kinase 1 ( P < 0.05) with no changes in mTORC1 signaling in the SNP trial ( P > 0.05). We conclude that reactive hyperemia is not a primary mechanism for BFR exercise-induced mTORC1 signaling and MPS. Further research is necessary to elucidate the cellular mechanism(s) responsible for the increase in mTOR signaling, MPS, and hypertrophy following acute and chronic BFR exercise.

Practical Blood Flow Restriction Training Increases Acute Determinants of Hypertrophy Without Increasing Indices of Muscle Damage

2013 ◽  
Vol 27 (11) ◽  
pp. 3068-3075 ◽  
Author(s):  
Jacob M. Wilson ◽  
Ryan P. Lowery ◽  
Jordan M. Joy ◽  
Jeremy P. Loenneke ◽  
Marshall A. Naimo
Keyword(s):  
Blood Flow ◽  
Muscle Damage ◽  
Blood Flow Restriction ◽  
Flow Restriction
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