scholarly journals Acute ingestion of dietary nitrate increases muscle blood flow via local vasodilation during handgrip exercise in young adults

2018 ◽  
Vol 6 (2) ◽  
pp. e13572 ◽  
Author(s):  
Jennifer C. Richards ◽  
Matthew L. Racine ◽  
Christopher M. Hearon ◽  
Megan Kunkel ◽  
Gary J. Luckasen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Young Adults ◽  
Muscle Blood Flow ◽  
Handgrip Exercise ◽  
Dietary Nitrate ◽  
Acute Ingestion

scholarly journals Acute ingestion of dietary nitrate increases muscle blood flow via local vasodilation during exercise in young adults (705.9)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Jennifer Richards ◽  
Matthew Racine ◽  
Christopher Hearon ◽  
Rakesh Patel ◽  
Frank Dinenno
Keyword(s):  
Blood Flow ◽  
Young Adults ◽  
Muscle Blood Flow ◽  
Dietary Nitrate ◽  
Acute Ingestion

scholarly journals Effect of dietary nitrate supplementation on conduit artery blood flow, muscle oxygenation, and metabolic rate during handgrip exercise

2018 ◽  
Vol 125 (2) ◽  
pp. 254-262 ◽  
Author(s):  
Jesse C. Craig ◽  
Ryan M. Broxterman ◽  
Joshua R. Smith ◽  
Jason D. Allen ◽  
Thomas J. Barstow
Keyword(s):  
Blood Flow ◽  
Muscle Mass ◽  
Muscle Blood Flow ◽  
Muscle Oxygenation ◽  
Moderate Intensity ◽  
Handgrip Exercise ◽  
Exercise Tests ◽  
Dietary Nitrate ◽  
Positive Effects ◽  
Nitrate Supplementation

Dietary nitrate supplementation has positive effects on mitochondrial and muscle contractile efficiency during large muscle mass exercise in humans and on skeletal muscle blood flow (Q̇) in rats. However, concurrent measurement of these effects has not been performed in humans. Therefore, we assessed the influence of nitrate supplementation on Q̇ and muscle oxygenation characteristics during moderate- (40 %peak) and severe-intensity(85% peak) handgrip exercise in a randomized, double-blind, crossover design. Nine healthy men (age: 25 ± 2 yr) completed four constant-power exercise tests (2/intensity) randomly assigned to condition [nitrate-rich (nitrate) or nitrate-poor (placebo) beetroot supplementation] and intensity (40 or 85% peak). Resting mean arterial pressure was lower after nitrate compared with placebo (84 ± 4 vs. 89 ± 4 mmHg, P < 0.01). All subjects were able to sustain 10 min of exercise at 40% peak in both conditions. Nitrate had no effect on exercise tolerance during 85% peak (nitrate: 358 ± 29; placebo: 341 ± 34 s; P = 0.3). Brachial artery Q̇ was not different after nitrate at rest or any time during exercise. Deoxygenated [hemoglobin + myoglobin] was not different for 40% peak ( P > 0.05) but was elevated throughout 85% peak ( P < 0.05) after nitrate. The metabolic cost (V̇o2) was not different at the end of exercise; however, the V̇o2 primary amplitude at the onset of exercise was elevated after nitrate for the 85% peak work rate (96 ± 20 vs. 72 ± 12 ml/min, P < 0.05) and had a faster response. These findings suggest that an acute dose of nitrate reduces resting blood pressure and speeds V̇o2 kinetics in young adults but does not augment Q̇ or reduce steady-state V̇o2 during small muscle mass handgrip exercise. NEW & NOTEWORTHY We show that acute dietary nitrate supplementation via beetroot juice increases the amplitude and speed of local muscle V̇o2 on kinetics parameters during severe- but not moderate-intensity handgrip exercise. These changes were found in the absence of an increased blood flow response, suggesting that the increased V̇o2 was attained via improvements in fractional O2 extraction and/or spatial distribution of blood flow within the exercising muscle.

Skeletal muscle blood flow and vascular conductance are enhanced in humans with high‐affinity hemoglobin during handgrip exercise in severe hypoxia

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Chad C. Wiggins ◽  
Paolo B. Dominelli ◽  
Jonathon W. Senefeld ◽  
John R.A. Shepherd ◽  
Sarah E. Baker ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Blood Flow ◽  
Severe Hypoxia ◽  
Handgrip Exercise ◽  
Vascular Conductance ◽  
Skeletal Muscle Blood Flow ◽  
High Affinity

scholarly journals Muscle Blood Flow and Oxygen Utilization Measured by Near-Infrared Spectroscopy during Handgrip Exercise in Chronic Respiratory Patients

2009 ◽  
Vol 21 (3) ◽  
pp. 231-238 ◽  
Author(s):  
Kiyokazu Sekikawa ◽  
Kazuyuki Tabira ◽  
Noriko Sekikawa ◽  
Kotarou Kawaguchi ◽  
Makoto Takahashi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Handgrip Exercise ◽  
Oxygen Utilization

Dietary nitrate does not acutely enhance skeletal muscle blood flow and vasodilation in the lower limbs of older adults during single-limb exercise

2020 ◽  
Vol 120 (6) ◽  
pp. 1357-1369
Author(s):  
William E. Hughes ◽  
Nicholas T. Kruse ◽  
Kenichi Ueda ◽  
Andrew J. Feider ◽  
Satoshi Hanada ◽  
...  
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Blood Flow ◽  
Lower Limbs ◽  
Skeletal Muscle Blood Flow ◽  
Dietary Nitrate ◽  
Limb Exercise

scholarly journals Roles of nitric oxide synthase and cyclooxygenase in leg vasodilation and oxygen consumption during prolonged low-intensity exercise in untrained humans

2010 ◽  
Vol 109 (3) ◽  
pp. 768-777 ◽  
Author(s):  
William G. Schrage ◽  
Brad W. Wilkins ◽  
Christopher P. Johnson ◽  
John H. Eisenach ◽  
Jacqueline K. Limberg ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Young Adults ◽  
Oxygen Consumption ◽  
Steady State ◽  
Nitric Oxide Synthase ◽  
Muscle Blood Flow ◽  
Blood Gases ◽  
Whole Body ◽  
Oxide Synthase

The vasodilator signals regulating muscle blood flow during exercise are unclear. We tested the hypothesis that in young adults leg muscle vasodilation during steady-state exercise would be reduced independently by sequential pharmacological inhibition of nitric oxide synthase (NOS) and cyclooxygenase (COX) with NG-nitro-l-arginine methyl ester (l-NAME) and ketorolac, respectively. We tested a second hypothesis that NOS and COX inhibition would increase leg oxygen consumption (V̇o2) based on the reported inhibition of mitochondrial respiration by nitric oxide. In 13 young adults, we measured heart rate (ECG), blood pressure (femoral venous and arterial catheters), blood gases, and venous oxygen saturation (indwelling femoral venous oximeter) during prolonged (25 min) steady-state dynamic knee extension exercise (60 kick/min, 19 W). Leg blood flow (LBF) was determined by Doppler ultrasound of the femoral artery. Whole body V̇o2 was measured, and leg V̇o2 was calculated from blood gases and LBF. Resting intra-arterial infusions of acetylcholine (ACh) and nitroprusside (NTP) tested inhibitor efficacy. Leg vascular conductance (LVC) to ACh was reduced up to 53 ± 4% by l-NAME + ketorolac infusion, and the LVC responses to NTP were unaltered. Exercise increased LVC from 4 ± 1 to 33.1 ± 2 ml·min−1·mmHg−1 and tended to decrease after l-NAME infusion (31 ± 2 ml·min−1·mmHg−1, P = 0.09). With subsequent administration of ketorolac LVC decreased to 29.6 ± 2 ml·min−1·mmHg−1 ( P = 0.02; n = 9). While exercise continued, LVC returned to control values (33 ± 2 ml·min−1·mmHg−1) within 3 min, suggesting involvement of additional vasodilator mechanisms. In four additional subjects, LVC tended to decrease with l-NAME infusion alone ( P = 0.08) but did not demonstrate the transient recovery. Whole body and leg V̇o2 increased with exercise but were not altered by l-NAME or l-NAME + ketorolac. These data indicate a modest role for NOS- and COX-mediated vasodilation in the leg of exercising humans during prolonged steady-state exercise, which can be restored acutely. Furthermore, NOS and COX do not appear to influence muscle V̇o2 in untrained healthy young adults.

scholarly journals Acute ascorbic acid ingestion increases skeletal muscle blood flow and oxygen consumption via local vasodilation during graded handgrip exercise in older adults

2015 ◽  
Vol 309 (2) ◽  
pp. H360-H368 ◽  
Author(s):  
Jennifer C. Richards ◽  
Anne R. Crecelius ◽  
Dennis G. Larson ◽  
Frank A. Dinenno
Keyword(s):  
Older Adults ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Ascorbic Acid ◽  
Oxygen Consumption ◽  
Lower Body Negative Pressure ◽  
Muscle Blood Flow ◽  
Voluntary Contraction ◽  
Handgrip Exercise ◽  
Forearm Vascular Conductance

Human aging is associated with reduced skeletal muscle perfusion during exercise, which may be a result of impaired endothelium-dependent dilation and/or attenuated ability to blunt sympathetically mediated vasoconstriction. Intra-arterial infusion of ascorbic acid (AA) increases nitric oxide-mediated vasodilation and forearm blood flow (FBF) during handgrip exercise in older adults, yet it remains unknown whether an acute oral dose can similarly improve FBF or enhance the ability to blunt sympathetic vasoconstriction during exercise. We hypothesized that 1) acute oral AA would improve FBF (Doppler ultrasound) and oxygen consumption (V̇o2) via local vasodilation during graded rhythmic handgrip exercise in older adults ( protocol 1), and 2) AA ingestion would not enhance sympatholysis in older adults during handgrip exercise ( protocol 2). In protocol 1 ( n = 8; 65 ± 3 yr), AA did not influence FBF or V̇o2 during rest or 5% maximal voluntary contraction (MVC) exercise, but increased FBF (199 ± 13 vs. 248 ± 16 ml/min and 343 ± 24 vs. 403 ± 33 ml/min; P < 0.05) and V̇o2 (26 ± 2 vs. 34 ± 3 ml/min and 43 ± 4 vs. 50 ± 5 ml/min; P < 0.05) at both 15 and 25% MVC, respectively. The increased FBF was due to elevations in forearm vascular conductance (FVC). In protocol 2 ( n = 10; 63 ± 2 yr), following AA, FBF was similarly elevated during 15% MVC (∼20%); however, vasoconstriction to reflex increases in sympathetic activity during −40 mmHg lower-body negative pressure at rest (ΔFVC: −16 ± 3 vs. −16 ± 2%) or during 15% MVC (ΔFVC: −12 ± 2 vs. −11 ± 4%) was unchanged. Our collective results indicate that acute oral ingestion of AA improves muscle blood flow and V̇o2 during exercise in older adults via local vasodilation.

Muscle Blood Flow as a Determinant of Exercise Tolerance During Intermittent Isometric and Dynamic Handgrip Exercise

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S193 ◽  
Author(s):  
Julie A. Wilhelm ◽  
Allison J. Harper ◽  
Benjamin C. Thompson ◽  
Barry W. Scheuermann
Keyword(s):  
Blood Flow ◽  
Exercise Tolerance ◽  
Muscle Blood Flow ◽  
Handgrip Exercise

Muscle Blood Flow Responses to Dynamic Handgrip Exercise in Young Obese Adults

2017 ◽  
Vol 49 (5S) ◽  
pp. 827
Author(s):  
Kanokwan Bunsawat ◽  
Georgios Grigoriadis ◽  
Garett Griffith ◽  
Sang Ouk Wee ◽  
Elizabeth Schroeder ◽  
...  
Keyword(s):  
Blood Flow ◽  
Muscle Blood Flow ◽  
Handgrip Exercise ◽  
Obese Adults

scholarly journals Acute supplementation ofN-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise

2016 ◽  
Vol 4 (7) ◽  
pp. e12748 ◽  
Author(s):  
Joshua R. Smith ◽  
Ryan M. Broxterman ◽  
Carl J. Ade ◽  
Kara K. Evans ◽  
Stephanie P. Kurti ◽  
...  
Keyword(s):  
Blood Flow ◽  
Muscle Blood Flow ◽  
Handgrip Exercise
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