scholarly journals Lipopolysaccharide-induced inflammation does not alter muscle spindle afferent mechanosensation or sensory integration in the spinal cord of adult mice

2018 ◽  
Vol 6 (17) ◽  
pp. e13812
Author(s):  
Dasha Zaytseva ◽  
Anusha Allawala ◽  
Joy A. Franco ◽  
Shea Putnam ◽  
Adam M. Abtahie ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Muscle Spindle ◽  
Sensory Integration ◽  
Adult Mice

Dorsal Root Crush in Adult Mice to Study Spinal Cord Regeneration

BIO-PROTOCOL ◽  
2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hyukmin Kim ◽  
Harun Noristani ◽  
Seung Han ◽  
Young-Jin Son
Keyword(s):  
Spinal Cord ◽  
Dorsal Root ◽  
Spinal Cord Regeneration ◽  
Adult Mice

scholarly journals Brain-wide quantification of the supraspinal connectome

2021 ◽  
Author(s):  
Zimei Wang ◽  
Adam Romanski ◽  
Vatsal Mehra ◽  
Yunfang Wang ◽  
Benjamin C. Campbell ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Web Based ◽  
Locomotor Recovery ◽  
Adult Mice ◽  
Comprehensive Information ◽  
Normal Behavior ◽  
Wide Range ◽  
Cord Injury ◽  
Functional Consequences ◽  
Intuitive Manner

The supraspinal connectome is essential for normal behavior and homeostasis and consists of a wide range of sensory, motor, and autonomic projections from brain to spinal cord. Extensive work spanning a century has largely mapped the cell bodies of origin, yet their broad distribution and complex spatial relationships present significant challenges to the dissemination and application of this knowledge. Fields that study disruptions of supraspinal projections, for example spinal cord injury, have focused mostly on a handful of major populations that carry motor commands, with only limited consideration of dozens more that provide autonomic or crucial motor modulation. More comprehensive information is essential to understand the functional consequences of different injuries and to better evaluate the efficacy of treatments. Using viral retrograde labeling, 3D imaging, and registration to standard neuro-anatomical atlases we now provide a platform to profile the entire supraspinal connectome by rapidly visualizing and quantifying tens of thousands of supraspinal neurons, each assigned to more than 60 identified regions and nuclei throughout the brains of adult mice. We then use this tool to compare the lumbar versus cervically-projecting connectomes, to profile brain-wide the sensitivity of supraspinal populations to graded spinal injuries, and to correlate locomotor recovery with connectome measurements. To share these insights in an intuitive manner, we present an interactive web-based resource, which aims to spur progress by broadening understanding and analyses of essential but understudied supraspinal populations.

Domoic acid induced spinal cord lesions in adult mice: Evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions

2008 ◽  
Vol 29 (4) ◽  
pp. 700-707 ◽  
Author(s):  
Renshi Xu ◽  
Yuhui Tao ◽  
Chengsi Wu ◽  
Juan Yi ◽  
Yunzhu Yang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Spinal Cord ◽  
Excitatory Amino Acids ◽  
Domoic Acid ◽  
Molecular Pathways ◽  
Spinal Cord Lesions ◽  
Adult Mice

scholarly journals Spontaneous functional full recovery from motor and sensory deficits in adult mice after mild spinal cord injury

Heliyon ◽  
2019 ◽  
Vol 5 (6) ◽  
pp. e01847 ◽  
Author(s):  
Yohei Kakuta ◽  
Anna Adachi ◽  
Marino Yokohama ◽  
Toshiki Horii ◽  
Tokue Mieda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Full Recovery ◽  
Sensory Deficits ◽  
Adult Mice ◽  
Cord Injury

Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

2007 ◽  
Vol 426 (2) ◽  
pp. 69-74 ◽  
Author(s):  
Hiroki Takeuchi ◽  
Atsushi Natsume ◽  
Toshihiko Wakabayashi ◽  
Chihiro Aoshima ◽  
Shinji Shimato ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Dependent Manner ◽  
Injured Spinal Cord ◽  
Human Neural Stem Cells ◽  
Adult Mice

The Role of Glutamate in Maintaining Muscle Spindle Afferent Excitability in Adult Mice

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Serena Ortiz ◽  
Enoch Kim ◽  
Kimberly Than ◽  
Cebrina Bustos ◽  
Sarah Chu ◽  
...  
Keyword(s):  
Muscle Spindle ◽  
Adult Mice
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