Radial Basis Function Neural Network and Logistic Regression Analysis For Prognostic Classifi cation of Coronary Artery Disease Koroner Arter Hastalığının Sınıfl anmasında Radial Basis Fonsiyonu Sinir

BackgroundIt has been reported that lipoprotein(a) (Lp(a)) is associated with the risk of cardiovascular disease. The present study aimed to examine the association of Lp(a) levels with the presence and severity of coronary artery disease (CAD) in female patients.MethodsA total of 3712 female patients who received coronary angiography were consecutively enrolled. The levels of Lp(a) were measured and compared among patients with or without CAD, myocardial infarction and menopause. Spearman correlation analysis and logistic regression analysis were used to examine the association of Lp(a) with the presence of CAD and the severity of coronary atherosclerosis assessed by Gensini score (GS).ResultsThe average of Lp(a) levels was elevated as age increased in female subjects. Notably, women after menopause had higher Lp(a) levels compared with that before menopause (16.8 mg/dL (IQR 7.54–41.12 mg/dL) vs 14.7 mg/dL (IQR 6.72–30.82 mg/dL), p=0.002). Furthermore, multiple logistic regression analysis identified that Lp(a)>30 mg/dL was an independent risk factor of CAD in the postmenopausal females (OR: 1.33, 95% CI: 1.08 to 1.63, p=0.007). Finally, Lp(a) had a positive correlation with GS (r=0.11, p<0.001), and Lp(a)>30 mg/dL was an independent risk factor for high GS (OR: 1.43, 95% CI: 1.14 to 1.79, p=0.02) in the postmenopausal females.ConclusionCirculating Lp(a) levels were independently associated with the presence and severity of CAD in the postmenopausal females, suggesting that Lp(a) may be useful for prevention and risk-stratification of CAD in female individuals.

Download Full-text

Coronary risk factors used to predict coronary artery disease by logistic regression analysis.

Japanese Circulation Journal ◽

10.1253/jcj.56.1199 ◽

1992 ◽

Vol 56 (12) ◽

pp. 1199-1205 ◽

Cited By ~ 7

Author(s):

HIROFUMI KAMBARA ◽

AKIRA IMOTO ◽

CHIE OWADA ◽

SHUNICHI TAMAKI ◽

TETSURO FUDO ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Coronary Artery ◽

Logistic Regression Analysis ◽

Coronary Risk Factors ◽

Coronary Risk ◽

Artery Disease

Download Full-text

The use of radionuclide angiography in the diagnosis of coronary artery disease--a logistic regression analysis.

Circulation ◽

10.1161/01.cir.68.4.740 ◽

1983 ◽

Vol 68 (4) ◽

pp. 740-746 ◽

Cited By ~ 28

Author(s):

R J Gibbons ◽

K L Lee ◽

D Pryor ◽

F E Harrell ◽

R E Coleman ◽

...

Keyword(s):

Coronary Artery Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Coronary Artery ◽

Logistic Regression Analysis ◽

Radionuclide Angiography ◽

Artery Disease

Download Full-text

The communal relation ofMTHFR,MTR,ACEgene polymorphisms and hyperhomocysteinemia as conceivable risk of coronary artery disease

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2017-0030 ◽

2017 ◽

Vol 42 (10) ◽

pp. 1009-1014 ◽

Cited By ~ 4

Author(s):

Rizwan Masud ◽

Haider Zaigham Baqai

Keyword(s):

Coronary Artery Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Coronary Artery ◽

Logistic Regression Analysis ◽

Methylenetetrahydrofolate Reductase ◽

Pcr Amplification ◽

Nucleotide Polymorphisms ◽

Mthfr Polymorphisms ◽

Artery Disease

Homocysteine and its modulating genes have strongly emerged as novel biomarkers for coronary artery disease (CAD). In the present study, we investigated whether polymorphisms in homocysteine pathway genes and the plasma levels of homocysteine, folate, and vitamin B12, independently or in combination, are associated with CAD risk. A total of 504 participants were recruited (cases, n = 254; controls, n = 250, respectively). Tetra primer allele refractory mutation system polymerase chain reaction (PCR) was used for resolving the genotypes of 5′10′ methylenetetrahydrofolate reductase ‘MTHFR’ polymorphisms (rs1801133, rs1801131), 5′ methyl tetrahydrofolate homocysteine methyltransferase ‘MTR’ polymorphism (rs1805087), paroxanse1 ‘PON1’ polymorphism (rs662), and cystathionine beta synthase ‘CBS’ polymorphism (rs5742905). Conventional PCR amplification was carried out for resolving angiotensin converting enzyme ‘ACE’ insertion/deletion (I/D) polymorphism (rs4646994). ANOVA analysis, adjusted for the covariates, revealed that rs1801133, rs1805087 polymorphisms and homocysteine levels were associated with CAD. Logistic regression analysis (adjusted) revealed similar findings. Logistic regression analysis after applying factorial design to the studied single nucleotide polymorphisms (SNPs) revealed that homocysteine levels and heterozygous and mutant alleles at rs1801133, rs1805087, along with mutant alleles at rs1801131, rs4646994, conferred higher risk for CAD. Our results provide insight into the multifactorial nature of coronary artery disease. We highlight that SNPs in folate pathway genes and homocysteine have role in disease causation and can be used in disease prediction strategies.

Download Full-text

Relationship Between D-Dimer / Creatinine Ratio and Coronary Artery Disease Severity in Patients with ST-Segment Elevation Myocardial Infarction

10.20944/preprints202102.0485.v1 ◽

2021 ◽

Author(s):

Yipin Zhao ◽

Huawei Wang ◽

Zebin Lin ◽

Yingying Ji ◽

Qingwei Chen

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Coronary Artery ◽

Independent Predictor ◽

Gensini Score ◽

Multivariate Logistic Regression ◽

Artery Disease ◽

D Dimer

Backgroundː Previous studies have shown that both serum creatinine and D-dimer levels were associated with atherosclerotic coronary artery disease (CAD). We aimed to determine whether DCR is associated with coronary Gensini score in patients with ST-elevation myocardial infarction (STEMI). Methodsː 337 STEMI patients with complete D-dimer and creatinine and other necessary information were included in the analysis. According to the values of the DCR, patients were divided into the lower DCR group (DCR ≤ 1.42, n = 173) and the higher DCR group (DFR > 1.42, n = 174), and the differences between the two groups were compared. Multivariate linear and multivariate logistic regression analyses were performed to determine independent predictors of Gensini score. Resultsː High DCR group had higher Gensini score compared with low DCR group (P < 0.05). DCR was positively correlated with Gensini score (r=0.493, P < 0.001). Multiple linear regression analysis showed that Previous MI (r=11.312, P=0.035) and DCR (r=5.129, P<0.001) were independent risk factors associated with Gensini score. Multivariate logistic regression analysis showed that, compared to the group 1, DCR is independent risk factor for Group 2, Group 3, Group 4 (P <0.001). DCR is positively correlated with coronary Gensini score in STEMI patients and can be used as an independent predictor of higher Gensini score. Conclusionsː As a new and useful clinical marker, DCR is positively correlated with coronary Gensini score in STEMI patients and can be used as an independent predictor of higher Gensini score.

Download Full-text

The effect of p22-PHOX (CYBA) polymorphisms on premature coronary artery disease (≤ 40 years of age)

Thrombosis and Haemostasis ◽

10.1160/th10-08-0529 ◽

2011 ◽

Vol 105 (03) ◽

pp. 529-534 ◽

Cited By ~ 20

Author(s):

Georg Goliasch ◽

Andreas Grafl ◽

Elisabeth Ponweiser ◽

Hermann Blessberger ◽

Ioannis Tentzeris ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Coronary Artery ◽

Promoter Polymorphism ◽

P Value ◽

Artery Disease ◽

P22 Phox ◽

Cyba Gene

SummaryAcute myocardial infarction at a young age is associated with high morbidity and long-term mortality. The NADPH oxidase system as a main source of reactive oxygen species in vascular cells has been implicated in development and progression of coronary artery disease (CAD). In our study, we investigated the effect of polymorphisms in the p22-PHOX (CYBA) gene on CAD in young patients (≤ 40 years). We prospectively recruited 302 subjects into our multi-centre case control study, including 102 young myocardial infarction patients (≤ 40 years) from two high-volume cardiac catheterisation hospitals and frequency-matched them on age, gender, and center to 200 hospital controls in an approximate 2:1 ratio per case patient. The homozygote c.-930A>G promoter polymorphism was significantly more prevalent in the controls than in the infarction patients. In the adjusted logistic regression analysis, we detected a protective effect of the c.-930A>G promoter polymorphism against premature myocardial infarction. Using a logadditive/per-allele model, we detected an unadjusted odds ratio (OR) of 0.63 (95% confidence interval [CI] 0.45–0.9, p-value 0.011). In the adjusted model the association was more pronounced with an OR of 0.5 (95% CI 0.3–0.81, p-value 0.005). The C242T polymorphism and the 640A>G polymorphism did not differ significantly between the study groups. Furthermore we could not detect a significant effect for these polymorphisms in the logistic regression analysis. The present study suggests a protective association between the c.-930A>G promoter polymorphism in the p22-PHOX (CYBA) gene and the development of myocardial infarction in young individuals (≤ 40 years).

Download Full-text