The effect of p22-PHOX (CYBA) polymorphisms on premature coronary artery disease (≤ 40 years of age)

2011 ◽  
Vol 105 (03) ◽  
pp. 529-534 ◽  
Author(s):  
Georg Goliasch ◽  
Andreas Grafl ◽  
Elisabeth Ponweiser ◽  
Hermann Blessberger ◽  
Ioannis Tentzeris ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Coronary Artery ◽  
Promoter Polymorphism ◽  
P Value ◽  
Artery Disease ◽  
P22 Phox ◽  
Cyba Gene

SummaryAcute myocardial infarction at a young age is associated with high morbidity and long-term mortality. The NADPH oxidase system as a main source of reactive oxygen species in vascular cells has been implicated in development and progression of coronary artery disease (CAD). In our study, we investigated the effect of polymorphisms in the p22-PHOX (CYBA) gene on CAD in young patients (≤ 40 years). We prospectively recruited 302 subjects into our multi-centre case control study, including 102 young myocardial infarction patients (≤ 40 years) from two high-volume cardiac catheterisation hospitals and frequency-matched them on age, gender, and center to 200 hospital controls in an approximate 2:1 ratio per case patient. The homozygote c.-930A>G promoter polymorphism was significantly more prevalent in the controls than in the infarction patients. In the adjusted logistic regression analysis, we detected a protective effect of the c.-930A>G promoter polymorphism against premature myocardial infarction. Using a logadditive/per-allele model, we detected an unadjusted odds ratio (OR) of 0.63 (95% confidence interval [CI] 0.45–0.9, p-value 0.011). In the adjusted model the association was more pronounced with an OR of 0.5 (95% CI 0.3–0.81, p-value 0.005). The C242T polymorphism and the 640A>G polymorphism did not differ significantly between the study groups. Furthermore we could not detect a significant effect for these polymorphisms in the logistic regression analysis. The present study suggests a protective association between the c.-930A>G promoter polymorphism in the p22-PHOX (CYBA) gene and the development of myocardial infarction in young individuals (≤ 40 years).

scholarly journals Relationship Between D-Dimer / Creatinine Ratio and Coronary Artery Disease Severity in Patients with ST-Segment Elevation Myocardial Infarction

2021 ◽  
Author(s):  
Yipin Zhao ◽  
Huawei Wang ◽  
Zebin Lin ◽  
Yingying Ji ◽  
Qingwei Chen
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Coronary Artery ◽  
Independent Predictor ◽  
Gensini Score ◽  
Multivariate Logistic Regression ◽  
Artery Disease ◽  
D Dimer

Backgroundː Previous studies have shown that both serum creatinine and D-dimer levels were associated with atherosclerotic coronary artery disease (CAD). We aimed to determine whether DCR is associated with coronary Gensini score in patients with ST-elevation myocardial infarction (STEMI). Methodsː 337 STEMI patients with complete D-dimer and creatinine and other necessary information were included in the analysis. According to the values of the DCR, patients were divided into the lower DCR group (DCR ≤ 1.42, n = 173) and the higher DCR group (DFR > 1.42, n = 174), and the differences between the two groups were compared. Multivariate linear and multivariate logistic regression analyses were performed to determine independent predictors of Gensini score. Resultsː High DCR group had higher Gensini score compared with low DCR group (P < 0.05). DCR was positively correlated with Gensini score (r=0.493, P < 0.001). Multiple linear regression analysis showed that Previous MI (r=11.312, P=0.035) and DCR (r=5.129, P<0.001) were independent risk factors associated with Gensini score. Multivariate logistic regression analysis showed that, compared to the group 1, DCR is independent risk factor for Group 2, Group 3, Group 4 (P <0.001). DCR is positively correlated with coronary Gensini score in STEMI patients and can be used as an independent predictor of higher Gensini score. Conclusionsː As a new and useful clinical marker, DCR is positively correlated with coronary Gensini score in STEMI patients and can be used as an independent predictor of higher Gensini score.

The interleukin-6 G(–174)C promoter polymorphism in the LURIC cohort: no association with plasma interleukin-6, coronary artery disease, and myocardial infarction

2002 ◽  
Vol 80 (8) ◽  
pp. 507-513 ◽  
Author(s):  
Markus Nauck ◽  
Bernhard R. Winkelmann ◽  
Michael M. Hoffmann ◽  
Bernhard O. Böhm ◽  
Heinrich Wieland ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Interleukin 6 ◽  
Promoter Polymorphism ◽  
Artery Disease

scholarly journals Association between plasma big endothelin-1 level and the severity of coronary artery disease in patients with non-ST segment-elevated myocardial infarction

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Lyu ◽  
J Zhu ◽  
L Yu ◽  
Y Yang
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Coronary Artery ◽  
Independent Predictor ◽  
Curve Analysis ◽  
Syntax Score ◽  
Roc Curve Analysis ◽  
St Segment ◽  
Artery Disease

Abstract Background This study aimed to evaluate the association between plasma big endothelin-1 (ET-1) level and the severity of coronary artery disease assessed by the SYNTAX score (SS) in patient with non-ST segment-elevated myocardial infarction (NSTEMI). Methods A total of 766 patients with NSTEMI undergoing coronary angiography were recruited. Patients were divided into divided into three groups: low SS (SS ≤22), intermediate SS (23–32) and high SS group (SS >32). Spearman correlation, smooth curve fitting, logistic regression and Receiver operating characteristic (ROC) curve analysis were performed to evaluated the association between plasma big ET-1 level and the SS. Results There was a significant correlation between the big ET-1 and the SS (r=0.378, p<0.001). Smoothing curve indicated a positive correlation between plasma big ET-1 level and the SS, after adjustment for potential confounders. The ROC curve analysis showed that the area under the curve was 0.695 (0.661–0.727) and the optimal cutoff of plasma big ET-1 level were 0.35pmol/l, with a sensitivity of 68.9% and a specificity of 62.9%. Logistic regression showed that elevated big ET-1 was an independent predictor of intermediate-high SS in patients with NSTEMI, no matter entered as a continuous variable [OR (95% CI): 1.110 (1.053–1.170), p<0.001] or as a categorical variable [OR (95% CI): 2.873 (2.016–4.094), p<0.001]. The association between big ET-1 and intermediate-high SS was consistent across subgroups without significant interactions. Conclusion In patients presenting with NSTEMI, plasma big ET-1 level was significantly correlated with the SS. Elevated plasma big ET-1 level was an independent predictor for intermediate-high SS. FUNDunding Acknowledgement Type of funding sources: None. ROC of big ET-1 for high SYNTAX score

Lipoprotein(a) and coronary artery disease in Chinese postmenopausal female patients: a large cross-sectional cohort study

2019 ◽  
Vol 95 (1128) ◽  
pp. 534-540 ◽  
Author(s):  
Shuo-Lin Liu ◽  
Na-Qiong Wu ◽  
Yuan-Lin Guo ◽  
Cheng-Gang Zhu ◽  
Ying Gao ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Risk Factor ◽  
Coronary Artery ◽  
Logistic Regression Analysis ◽  
Independent Risk Factor ◽  
Lipoprotein A ◽  
Female Patients ◽  
Artery Disease

BackgroundIt has been reported that lipoprotein(a) (Lp(a)) is associated with the risk of cardiovascular disease. The present study aimed to examine the association of Lp(a) levels with the presence and severity of coronary artery disease (CAD) in female patients.MethodsA total of 3712 female patients who received coronary angiography were consecutively enrolled. The levels of Lp(a) were measured and compared among patients with or without CAD, myocardial infarction and menopause. Spearman correlation analysis and logistic regression analysis were used to examine the association of Lp(a) with the presence of CAD and the severity of coronary atherosclerosis assessed by Gensini score (GS).ResultsThe average of Lp(a) levels was elevated as age increased in female subjects. Notably, women after menopause had higher Lp(a) levels compared with that before menopause (16.8 mg/dL (IQR 7.54–41.12 mg/dL) vs 14.7 mg/dL (IQR 6.72–30.82 mg/dL), p=0.002). Furthermore, multiple logistic regression analysis identified that Lp(a)>30 mg/dL was an independent risk factor of CAD in the postmenopausal females (OR: 1.33, 95% CI: 1.08 to 1.63, p=0.007). Finally, Lp(a) had a positive correlation with GS (r=0.11, p<0.001), and Lp(a)>30 mg/dL was an independent risk factor for high GS (OR: 1.43, 95% CI: 1.14 to 1.79, p=0.02) in the postmenopausal females.ConclusionCirculating Lp(a) levels were independently associated with the presence and severity of CAD in the postmenopausal females, suggesting that Lp(a) may be useful for prevention and risk-stratification of CAD in female individuals.

scholarly journals Analysis on Outcome of 3537 Patients with Coronary Artery Disease: Integrative Medicine for Cardiovascular Events

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Zhu-ye Gao ◽  
Yu Qiu ◽  
Yang Jiao ◽  
Qing-hua Shang ◽  
Hao Xu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Coronary Artery Disease ◽  
Regression Analysis ◽  
Coronary Artery ◽  
Integrative Medicine ◽  
Cardiovascular Events ◽  
Artery Disease ◽  
One Year ◽  
Beijing China

Aims. To investigate the treatment of hospitalized patients with coronary artery disease (CAD) and the prognostic factors in Beijing, China.Materials and Methods. A multicenter prospective study was conducted through an integrative platform of clinical and research at 12 hospitals in Beijing, China. The clinical information of 3537 hospitalized patients with CAD was collected from September 2009 to May 2011, and the efficacy of secondary prevention during one-year followup was evaluated. In addition, a logistic regression analysis was performed to identify some factors which will have independent impact on the prognosis.Results. The average age of all patients was 64.88 ± 11.97. Of them, 65.42% are males. The medicines for patients were as follows: antiplatelet drugs accounting for 91.97%, statins accounting for 83.66%,β-receptor blockers accounting for 72.55%, ACEI/ARB accounting for 58.92%, and revascularization (including PCI and CABG) accounting for 40.29%. The overall incidence of cardiovascular events was 13.26% (469/3537). The logistic stepwise regression analysis showed that heart failure (OR, 3.707, 95% CI = 2.756–4.986), age ≥ 65 years old (OR, 2.007, 95% CI = 1.587–2.53), and myocardial infarction (OR, 1.649, 95% CI = 1.322–2.057) were the independent risk factors of others factors for cardiovascular events that occurred during followup of one-year period. Integrative medicine (IM) therapy showed the beneficial tendency for decreasing incidence of cardiovascular events, although no statistical significance was found (OR, 0.797, 95% CI = 0.613~1.036).Conclusions. Heart failure, age ≥ 65 years old, and myocardial infarction were associated with an increase in incidence of cardiovascular events, and treatment with IM showed a tendency for decreasing incidence of cardiovascular events.

scholarly journals Coronary risk factors used to predict coronary artery disease by logistic regression analysis.

1992 ◽  
Vol 56 (12) ◽  
pp. 1199-1205 ◽  
Author(s):  
HIROFUMI KAMBARA ◽  
AKIRA IMOTO ◽  
CHIE OWADA ◽  
SHUNICHI TAMAKI ◽  
TETSURO FUDO ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Coronary Artery ◽  
Logistic Regression Analysis ◽  
Coronary Risk Factors ◽  
Coronary Risk ◽  
Artery Disease

scholarly journals The ratio of HDL-C to apoA-I interacts with free triiodothyronine to modulate coronary artery disease risk

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Li Li ◽  
Gaojun Cai ◽  
Wei Lu ◽  
Feng Li ◽  
Lei Yu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Coronary Artery ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Free Triiodothyronine ◽  
Negatively Associated ◽  
Increased Risk ◽  
Artery Disease

Abstract Objective In the present work, research was carried out to explore the correlation between the high-density lipoprotein cholesterol (HDL-C)/apolipoprotein A-I (apoA-I) ratio and serum free triiodothyronine (FT3) and their interaction on the risk of coronary artery disease (CAD). Methods A total of 1686 patients who underwent selective coronary angiography were enrolled in the present study, including 1279 patients with CAD and 407 controls. The subjects were divided into three groups according to tertiles of the HDL-C/apoA-I ratio. Binary logistic regression analysis was used to evaluate the interaction of the HDL-C/apoA-I ratio and FT3 level with the risk of CAD. Results The group with the highest HDL-C/apoA-I ratio had the lowest levels of FT3. Multiple linear regression analysis showed that the HDL-C/apoA-I ratio was negatively associated with FT3 after adjusting for age, sex, body mass index (BMI), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), FT4 and TSH. A logistic regression model showed that a high HDL-C/apoA-I ratio (> 0.89 mmol/g) and high FT3 levels (> 4.5 pmol/l) were protective factors for CAD. Patients with a lower HDL-C/apoA-I ratio (≤ 0.89 mmol/g) and lower FT3 level (≤ 4.5 pmol/l) had an increased risk of CAD (OR = 2.441, P = 0.000, S = 1.13, AP = 0.068, AP* = 0.116, RERI = 0.168). Conclusions The HDL-C/apoA-I ratio was negatively associated with FT3, and there was a significant interaction between the HDL-C/apoA-I ratio and FT3 with the risk of CAD.

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