Service peculiarities and the specific role of technology in service innovation management

Innovation is an important key for an organization to win the market competition, both in aspects of organization, culture, and business to produce an excellence service and product. Service innovation has been developed to respond quickly the demand of society that increasingly aware of the importance of quality service. PT. Kereta Api Indonesia (KAI) as one of the Indonesian state-owned companies engaged in public transportation made a breakthrough by launching a service product innovation, purchasing system of train tickets and new trains. This paper analyzes the types of service product innovation, success factors of innovation, and explore the barriers of innovation. This study used qualitative methods based on review of the innovation management literature and semi-structured interviews. The role of leadership has an important influence in shaping the behavior of the organization. These organizational learning concepts are used to gain a dynamic of service innovation, it suggests that the company should still perform improvement processes in developing service innovation to meet the challenges faced.

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Secretory leukocyte protease inhibitor expression in various types of gastritis – a specific role of H. pylori infection

Zeitschrift für Gastroenterologie ◽

10.1055/s-2006-943414 ◽

2006 ◽

Vol 44 (05) ◽

Author(s):

I Hritz ◽

L Herszényi ◽

T Wex ◽

P Malfertheiner ◽

Z Tulassay

Keyword(s):

Protease Inhibitor ◽

Secretory Leukocyte Protease Inhibitor ◽

Specific Role ◽

H Pylori

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Interpassivity and Misdemeanours: The Art of Thinking in Examples and the Žižekian Toolbox

10.3366/edinburgh/9781474422925.003.0005 ◽

2018 ◽

Author(s):

Robert Pfaller

Keyword(s):

Specific Role ◽

Slavoj Zizek ◽

Slavoj Žižek ◽

The Sublime

Starting from a passage from Slavoj Žižek`s brilliant book The Sublime Object of Ideology, the very passage on canned laughter that gave such precious support for the development of the theory of interpassivity, this chapter examines a question that has proved indispensable for the study of interpassivity: namely, what does it mean for a theory to proceed by examples? What is the specific role of the example in certain example-friendly theories, for example in Žižek’s philosophy?

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Faculty Opinions recommendation of Level-specific role of paraxial mesoderm in regulation of Tbx5/Tbx4 expression and limb initiation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1032591.374289 ◽

2006 ◽

Author(s):

Jonathan Slack

Keyword(s):

Specific Role ◽

Paraxial Mesoderm ◽

Limb Initiation

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A Sex-Specific Role of Endothelial Sirtuin 3 on Blood Pressure and Diastolic Dysfunction in Female Mice

International Journal of Molecular Sciences ◽

10.3390/ijms21249744 ◽

2020 ◽

Vol 21 (24) ◽

pp. 9744

Author(s):

Heng Zeng ◽

Xiaochen He ◽

Jian-Xiong Chen

Keyword(s):

Blood Pressure ◽

Diastolic Dysfunction ◽

Diastolic Function ◽

Normal Diet ◽

Specific Role ◽

Sirtuin 3 ◽

Control Female ◽

Female Mice ◽

Flow Reserve

Background: Heart failure with preserved ejection fraction (HFpEF) is characterized by a diastolic dysfunction and is highly prevalent in aged women. Our study showed that ablation of endothelial Sirtuin 3 (SIRT3) led to diastolic dysfunction in male mice. However, the sex-specific role of endothelial SIRT3 deficiency on blood pressure and diastolic function in female mice remains to be investigated. Methods and Results: In this study, we demonstrate that the ablation of endothelial SIRT3 in females elevated blood pressure as compared with control female mice. Diastolic function measurement also showed that the isovolumic relaxation time (IVRT) and myocardial performance index (MPI) were significantly increased, whereas the E’ velocity/A’ velocity (E’/A’) ratio was reduced in the endothelial-specific SIRT3 knockout (SIRT3 ECKO) female mice. To further investigate the regulatory role of endothelial SIRT3 on blood pressure and diastolic dysfunction in metabolic stress, SIRT3 ECKO female mice were fed a normal diet and high-fat diet (HFD) for 20 weeks. The knockout of endothelial SIRT3 resulted in an increased blood pressure in female mice fed with an HFD. Intriguingly, SIRT3 ECKO female mice + HFD exhibited impaired coronary flow reserve (CFR) and more severe diastolic dysfunction as evidenced by an elevated IVRT as compared with control female mice + HFD. In addition, female SIRT3 ECKO mice had higher blood pressure and diastolic dysfunction as compared to male SIRT3 ECKO mice. Moreover, female SIRT3 ECKO mice + HFD had an impaired CFR and diastolic dysfunction as compared to male SIRT3 ECKO mice + HFD. Conclusions: These results implicate a sex-specific role of endothelial SIRT3 in regulating blood pressure and diastolic function in mice. Deficiency of endothelial SIRT3 may be responsible for a diastolic dysfunction in aged female.

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Understanding the role of service innovation behavior on business customer performance and loyalty

Industrial Marketing Management ◽

10.1016/j.indmarman.2020.12.011 ◽

2021 ◽

Vol 93 ◽

pp. 41-51

Author(s):

Heeseok Woo ◽

Sang Jin Kim ◽

Huanzhang Wang

Keyword(s):

Service Innovation ◽

Innovation Behavior

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A MODEL OF CREATIVE HERITAGE FOR INDUSTRY: DESIGNING NEW RULES WHILE PRESERVING THE PRESENT SYSTEM OF RULES

Proceedings of the Design Society ◽

10.1017/pds.2021.15 ◽

2021 ◽

Vol 1 ◽

pp. 141-150

Author(s):

Honorine Harlé ◽

Pascal Le Masson ◽

Benoit Weil

Keyword(s):

Case Studies ◽

Design Process ◽

Industry 4.0 ◽

Innovation Management ◽

Present System ◽

Innovative Capability ◽

Current Change ◽

A Site ◽

Do So

AbstractIn industry, there is at once a strong need for innovation and a need to preserve the existing system of production. Thus, although the literature insists on the necessity of the current change toward Industry 4.0, how to implement it remains problematic because the preservation of the factory is at stake. Moreover, the question of the evolution of the system depends on its innovative capability, but it is difficult to understand how a new rule can be designed and implemented in a factory. This tension between preservation and innovation is often explained in the literature as a process of creative destruction. Looking at the problem from another perspective, this article models the factory as a site of creative heritage, enabling creation within tradition, i.e., creating new rules while preserving the system of rules. Two case studies are presented to illustrate the model. The paper shows that design in the factory relies on the ability to validate solutions. To do so, the design process can explore and give new meaning to the existing rules. The role of innovation management is to choose the degree of revision of the rules and to make it possible.

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Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

Acta Neuropathologica Communications ◽

10.1186/s40478-021-01231-5 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Angela Jeong ◽

Shaowu Cheng ◽

Rui Zhong ◽

David A. Bennett ◽

Martin O. Bergö ◽

...

Keyword(s):

Cognitive Impairment ◽

Small Gtpases ◽

Specific Role ◽

Postmortem Brain ◽

Effective Prevention ◽

Postmortem Brain Tissue ◽

Mtorc1 Signaling ◽

Behavioral Assessments ◽

Human Brains

AbstractThe pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD. Farnesyltransferase (FT) catalyzes a key posttranslational modification process called farnesylation, in which the isoprenoid farnesyl pyrophosphate is attached to target proteins, facilitating their membrane localization and their interactions with downstream effectors. Farnesylated proteins, including the Ras superfamily of small GTPases, are involved in regulating diverse physiological and pathological processes. Emerging evidence suggests that isoprenoids and farnesylated proteins may play an important role in the pathogenesis of AD. However, the dynamics of FT and protein farnesylation in human brains and the specific role of neuronal FT in the pathogenic progression of AD are not known. Here, using postmortem brain tissue from individuals with no cognitive impairment (NCI), mild cognitive impairment (MCI), or Alzheimer’s dementia, we found that the levels of FT and membrane-associated H-Ras, an exclusively farnesylated protein, and its downstream effector ERK were markedly increased in AD and MCI compared with NCI. To elucidate the specific role of neuronal FT in AD pathogenesis, we generated the transgenic AD model APP/PS1 mice with forebrain neuron-specific FT knockout, followed by a battery of behavioral assessments, biochemical assays, and unbiased transcriptomic analysis. Our results showed that the neuronal FT deletion mitigates memory impairment and amyloid neuropathology in APP/PS1 mice through suppressing amyloid generation and reversing the pathogenic hyperactivation of mTORC1 signaling. These findings suggest that aberrant upregulation of protein farnesylation is an early driving force in the pathogenic cascade of AD and that targeting FT or its downstream signaling pathways presents a viable therapeutic strategy against AD.

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