scholarly journals Nitric Oxide Plays No Role in ACTH Release Induced by Interleukin-1.BETA., Corticotropin-Releasing Hormone, Arginine Vasopressin and Phorbol Myristate Acetate in Rat Pituitary Cell Cultures.

1995 ◽  
Vol 42 (3) ◽  
pp. 435-439 ◽  
Author(s):  
KOZO HASHIMOTO ◽  
TATSUYA NISHIOKA ◽  
CHISA TOJO ◽  
TOSHIHIRO TAKAO
Keyword(s):  
Nitric Oxide ◽  
Cell Cultures ◽  
Phorbol Myristate Acetate ◽  
Arginine Vasopressin ◽  
Interleukin 1 ◽  
Pituitary Cell ◽  
Interleukin 1 Beta ◽  
Myristate Acetate ◽  
Rat Pituitary ◽  
Acth Release

Role for serotonin3 receptors in the control of adrenocorticotropic hormone release from rat pituitary cell cultures

1995 ◽  
Vol 133 (2) ◽  
pp. 251-254 ◽  
Author(s):  
Aldo E Calogero ◽  
Gyorgy Bagdy ◽  
Nunziatina Burrello ◽  
Pietro Polosa ◽  
Rosario D'Agata
Keyword(s):  
Pituitary Gland ◽  
Receptor Antagonist ◽  
Cell Cultures ◽  
Adrenocorticotropic Hormone ◽  
Pituitary Cell ◽  
Hormone Release ◽  
Mdl 72222 ◽  
Rat Pituitary ◽  
Ics 205 930 ◽  
Acth Release

Calogero AE, Bagdy G, Burrello N, Polosa P. D'Agata R. Role for serotonin3 receptors in the control of adrenocorticotropic hormone release from rat pituitary cell cultures. Eur J Endocrinol 1995;133:251–4. ISSN 0804–4643 Although several serotonin (5-HT) receptor types have been shown capable of stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland, relatively little is known about the role of the 5-HT3 receptor, a receptor that has generated a great deal of interest for its involvement in many behavioral and therapeutic effects. Hence, in this study, we tested the effects of the 5-HT¾ receptor antagonist 3-tropanyl-indole-3-carboxylate (ICS 205-930) and the selective 5-HT3 receptor antagonist 3-tropanyl-3,5-dichlorobenzoate (MDL 72222) on ACTH release stimulated by 5-HT from primary cultures of rat pituitary cells. Subsequently, we evaluated the effects of the selective 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide (m-CPBG) on basal, corticotropin-releasing hormone (CRH)- and arginine vasopressin (AVP)-stimulated ACTH release. The maximal stimulatory effect of 5-HT (10−9 mol/l on ACTH release was antagonized by both ICS 205-930 and MDL 72222, suggesting that 5-HT stimulates basal ACTH release through activation of 5-HT3 receptors. Accordingly, m-CPBG stimulated basal ACTH release in a concentration-dependent fashion. In contrast to 5-HT, m-CPBG did not have any effect on CRH-stimulated ACTH release and inhibited AVP-stimulated ACTH release in a concentration-dependent manner. These data suggest that the 5-HT3 receptor is involved in the release of ACTH from the pituitary gland in vitro. Aldo E Calogero, Istituto di Clinica Medica I, Ospedale Garibaldi, Piazza S Maria di Gesú, 95123 Catania, Italy

Comparison of mitogenic activity of (Bu)2cAMP and different growth factors in rat pituitary cell cultures and the influence on hormone secretion

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S193
Author(s):  
L. ANGERMÜLLER ◽  
G. K. STALLA ◽  
J. STALLA ◽  
J. MOJTO ◽  
O. A. MÜLLER
Keyword(s):  
Growth Factors ◽  
Cell Cultures ◽  
Hormone Secretion ◽  
Pituitary Cell ◽  
Mitogenic Activity ◽  
Rat Pituitary

scholarly journals Effect of 17β-Estradiol on Somatostatin Receptor Expression and Inhibitory Effects on Growth Hormone and Prolactin Release in Rat Pituitary Cell Cultures

Endocrinology ◽  
1998 ◽  
Vol 139 (5) ◽  
pp. 2272-2277 ◽  
Author(s):  
D. Djordjijevic ◽  
J. Zhang ◽  
M. Priam ◽  
C. Viollet ◽  
D. Gourdji ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cell Cultures ◽  
Somatostatin Receptor ◽  
Pituitary Cell ◽  
Receptor Expression ◽  
Inhibitory Effects ◽  
Prolactin Release ◽  
Rat Pituitary ◽  
17Β Estradiol

scholarly journals Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.

1992 ◽  
Vol 90 (6) ◽  
pp. 2384-2391 ◽  
Author(s):  
J A Corbett ◽  
J L Wang ◽  
M A Sweetland ◽  
J R Lancaster ◽  
M L McDaniel
Keyword(s):  
Nitric Oxide ◽  
Beta Cell ◽  
Beta Cells ◽  
Islets Of Langerhans ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
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