scholarly journals Association Study of Human MTH1 Gene Polymorphisms with Type 1 Diabetes Mellitus

2004 ◽  
Vol 51 (5) ◽  
pp. 493-498 ◽  
Author(s):  
Kenichi MIYAKO ◽  
Hitoshi KOHNO ◽  
Kenji IHARA ◽  
Ryuichi KUROMARU ◽  
Nobuo MATSUURA ◽  
...  
Author(s):  
Melina Bezerra Loureiro ◽  
Marcela Abbott Galvão Ururahy ◽  
Karla Simone Costa de Souza ◽  
Yonara Monique da Costa Oliveira ◽  
Heglayne Pereira Vital da Silva ◽  
...  

2006 ◽  
Vol 33 (1) ◽  
pp. 7-10 ◽  
Author(s):  
R. Ni ◽  
K. Ihara ◽  
K. Miyako ◽  
M. Takemoto ◽  
M. Ishimura ◽  
...  

2011 ◽  
Vol 39 (2) ◽  
pp. 831-837 ◽  
Author(s):  
Zahra Mohammadnejad ◽  
Mohsen Ghanbari ◽  
Rashin Ganjali ◽  
Jalil Tavakkol Afshari ◽  
Mahyar Heydarpour ◽  
...  

1998 ◽  
Vol 47 (3-4) ◽  
pp. 171-176
Author(s):  
M. Krokowski ◽  
M. Abel ◽  
A. Teodorczyk ◽  
A. Szadkowska ◽  
B. Pyrżak ◽  
...  

AbstractType 1 diabetes mellitus (IDDM) results from a chronic process of autoimmune destruction of ß cells of the Langerhans islets. The presence of autoantibodies (ICA, GADA, anti-IA2, IAA) in serum preceds the clinical onset of the disease. Genetic predisposition for IDDM is connected with HLA, CTLA-4 and insulin gene region.The aim of the study was the genetic and immunological analysis of a triplet. One of them developed Type 1 diabetes mellitus. We analysed HLA class II, CTLA-4 and insulin gene polymorphisms in the whole family. Besides, we investigated immunological status of three brothers.All patients present identical genotype for VNTR loci: D1S80, D17S5 and Apo B, as well as for HLA-DRB1, — DQA1, — DQB1, CTLA-4 gene and all studied insulin gene polymorphisms. That proves their monozigosity. The triplet presents strong genetic predisposition for IDDM. The two patients without overt diabetes have increased levels of ICA, GADA, IA2 and IAA.


2015 ◽  
Vol 57 (5) ◽  
pp. 870-874 ◽  
Author(s):  
Chong-Kun Cheon ◽  
Hyo-Kyoung Nam ◽  
Kee-Hyoung Lee ◽  
Su Yung Kim ◽  
Ji Sun Song ◽  
...  

Autoimmunity ◽  
2013 ◽  
Vol 46 (6) ◽  
pp. 382-387 ◽  
Author(s):  
Jaqueline De Azevêdo Silva ◽  
Rafael Lima Guimarães ◽  
Lucas André Cavalcanti Brandão ◽  
Jacqueline Araujo ◽  
Ludovica Segat ◽  
...  

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