Type 1 Diabetes and Prediabetic State in a Monozygotic Triplet

1998 ◽  
Vol 47 (3-4) ◽  
pp. 171-176
Author(s):  
M. Krokowski ◽  
M. Abel ◽  
A. Teodorczyk ◽  
A. Szadkowska ◽  
B. Pyrżak ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Genetic Predisposition ◽  
Gene Polymorphisms ◽  
Insulin Gene ◽  
Prediabetic State ◽  
Apo B ◽  
Clinical Onset

AbstractType 1 diabetes mellitus (IDDM) results from a chronic process of autoimmune destruction of ß cells of the Langerhans islets. The presence of autoantibodies (ICA, GADA, anti-IA2, IAA) in serum preceds the clinical onset of the disease. Genetic predisposition for IDDM is connected with HLA, CTLA-4 and insulin gene region.The aim of the study was the genetic and immunological analysis of a triplet. One of them developed Type 1 diabetes mellitus. We analysed HLA class II, CTLA-4 and insulin gene polymorphisms in the whole family. Besides, we investigated immunological status of three brothers.All patients present identical genotype for VNTR loci: D1S80, D17S5 and Apo B, as well as for HLA-DRB1, — DQA1, — DQB1, CTLA-4 gene and all studied insulin gene polymorphisms. That proves their monozigosity. The triplet presents strong genetic predisposition for IDDM. The two patients without overt diabetes have increased levels of ICA, GADA, IA2 and IAA.

scholarly journals Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus

2018 ◽  
Vol 53 (4) ◽  
Author(s):  
Melina Bezerra Loureiro ◽  
Marcela Abbott Galvão Ururahy ◽  
Karla Simone Costa de Souza ◽  
Yonara Monique da Costa Oliveira ◽  
Heglayne Pereira Vital da Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Type 1 Diabetes Mellitus ◽  
Bone Mineral ◽  
Gene Polymorphisms ◽  
Lower Bone Mineral Density ◽  
Mineral Density

scholarly journals Phenotypic and environmental factors associated with elevated autoantibodies at clinical onset of paediatric type 1 diabetes mellitus

2012 ◽  
Vol 2 ◽  
pp. 125-131 ◽  
Author(s):  
Anne-Louise Ponsonby ◽  
Angela Pezic ◽  
Fergus J. Cameron ◽  
Christine Rodda ◽  
Justine A. Ellis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Environmental Factors ◽  
Type 1 Diabetes Mellitus ◽  
Factors Associated ◽  
Clinical Onset

Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in type 1 diabetes mellitus

2005 ◽  
Vol 39 (2) ◽  
pp. 200-205
Author(s):  
E. V. Zotova ◽  
O. E. Voron’ko ◽  
T. R. Bursa ◽  
I. V. Galeev ◽  
I. A. Strokov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Genetic Predisposition ◽  
Diabetic Polyneuropathy ◽  
No Synthase ◽  
Polymorphic Markers

Association between vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in Iranian population

2011 ◽  
Vol 39 (2) ◽  
pp. 831-837 ◽  
Author(s):  
Zahra Mohammadnejad ◽  
Mohsen Ghanbari ◽  
Rashin Ganjali ◽  
Jalil Tavakkol Afshari ◽  
Mahyar Heydarpour ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms
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