Vitamin D binding protein gene polymorphisms and risk of type 1 diabetes mellitus among Egyptians

2011 ◽  
Vol 29 (2) ◽  
Author(s):  
MA Mahmoud ◽  
GH Ibrahim ◽  
MS Fawzy ◽  
HA Atwa
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Binding Protein Gene

scholarly journals No association between the vitamin D-binding protein (DBP) gene polymorphisms (rs7041 and rs4588) and multiple sclerosis and type 1 diabetes mellitus: A meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0242256
Author(s):  
Xin Zhang ◽  
Bai Gao ◽  
Bing Xu
Keyword(s):  
Diabetes Mellitus ◽  
Multiple Sclerosis ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Binding Protein ◽  
Meta Analysis ◽  
Genome Wide Association Studies ◽  
Vitamin D Binding Protein

Background The association between polymorphisms in vitamin D-binding protein (DBP) gene and the risk of multiple sclerosis (MS) and type 1 diabetes mellitus (T1DM) has been investigated in many studies, but the studies showed controversial results. The rationale for this meta-analysis was to determine whether DBP polymorphisms increases the risk of MS and T1DM by pooling data. Methods Potentially relevant studies were searched using GWAS Catalog, PubMed, Embase, CNKI and WANFANG databases up to November 2019. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were performed to estimate the associations in a fixed-effects or random-effects model. Results A total of 13 studies were enrolled in this meta-analysis, including eight studies for MS and five for T1DM. The overall results showed that there was no significant association of DBP rs7041 and rs4588 polymorphisms with the risk of MS and T1DM under any genetic model. Similarly, subgroup analysis by ethnicity revealed that no significant association of rs7041 and rs4588 polymorphisms with the risk of MS and T1DM was observed in white or non-white racial groups. Conclusions This meta-analysis provides evidence that DBP rs7041 and rs4588 polymorphisms may not be associated with an increased risk in MS and T1DM. However, these findings need further validation by larger-scale epidemiological studies and genome-wide association studies (GWASs) in different populations.

Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort

2017 ◽  
Vol 305 ◽  
pp. 92-95 ◽  
Author(s):  
Cristina Agliardi ◽  
Franca Rosa Guerini ◽  
Milena Zanzottera ◽  
Elisabetta Bolognesi ◽  
Andrea Saul Costa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Binding Protein Gene ◽  
Italian Cohort

Association between vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in Iranian population

2011 ◽  
Vol 39 (2) ◽  
pp. 831-837 ◽  
Author(s):  
Zahra Mohammadnejad ◽  
Mohsen Ghanbari ◽  
Rashin Ganjali ◽  
Jalil Tavakkol Afshari ◽  
Mahyar Heydarpour ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms

scholarly journals Clinical aspects of vitamin D-binding protein gene polymorphisms in hemodialysis patients

2015 ◽  
Vol 125 (1-2) ◽  
pp. 8-17 ◽  
Author(s):  
Alicja E. Grzegorzewska ◽  
Grzegorz Ostromecki ◽  
Adrianna Mostowska ◽  
Anna Sowińska ◽  
Paweł P. Jagodziński
Keyword(s):  
Vitamin D ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Binding Protein ◽  
Hemodialysis Patients ◽  
Clinical Aspects ◽  
Vitamin D Binding Protein ◽  
Binding Protein Gene

No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS

2002 ◽  
Vol 127 (1-2) ◽  
pp. 177-179 ◽  
Author(s):  
Masaaki Niino ◽  
Seiji Kikuchi ◽  
Toshiyuki Fukazawa ◽  
Ichiro Yabe ◽  
Kunio Tashiro
Keyword(s):  
Vitamin D ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Binding Protein ◽  
Japanese Patients ◽  
Vitamin D Binding Protein ◽  
Binding Protein Gene

Vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in a Korean population

2015 ◽  
Vol 57 (5) ◽  
pp. 870-874 ◽  
Author(s):  
Chong-Kun Cheon ◽  
Hyo-Kyoung Nam ◽  
Kee-Hyoung Lee ◽  
Su Yung Kim ◽  
Ji Sun Song ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphisms
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