High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome

Background: An association between nonalcoholic fatty liver disease (NAFLD) and low vitamin D levels has been suggested. We investigated the relationship between vitamin D and NAFLD assessed by controlled attenuation parameter (CAP). Methods: We conducted a retrospective cohort study of apparently healthy subjects who underwent Fibroscan during health screening tests. NAFLD was diagnosed using CAP values. Results: Among the 1202 subjects (mean age 57.2 years, 60.6% male), 630 (52.4%) subjects had NAFLD with CAP ≥ 248 dB/m. Multivariable analysis was conducted after adjusting for metabolic risk factors including diabetes, hypertension, hypercholesterolemia, body mass index, high-density lipoprotein cholesterol, triglyceride and smoking. Higher vitamin D levels showed a lower risk of NAFLD compared to the lowest quartile of vitamin D in a dose-dependent manner (OR 0.68, 95% CI 0.47–1.00 in Q2 vs. Q1; OR 0.65, 95% CI 0.44–0.94 in Q3 vs. Q1; and OR 0.64, 95% CI 0.44–0.94 in Q4 vs. Q1). The highest quartile of vitamin D showed a decreased risk of a severe grade of steatosis (CAP ≥ 302 dB/m) compared to the lowest quartile (OR 0.52, 95% CI 0.31–0.87 in Q4 vs. Q1). Conclusions: Higher levels of serum vitamin D were associated with a decreased risk of CAP-defined NAFLD, compared to low levels of serum vitamin D. The association between NAFLD and vitamin D suggests that vitamin D may exert a protective role against NAFLD.

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Association of nonalcoholic fatty liver disease with serum vitamin D levels in combination of physical fitness in korean older adults

The Journal of Steroid Biochemistry and Molecular Biology ◽

10.1016/j.jsbmb.2019.105569 ◽

2020 ◽

Vol 198 ◽

pp. 105569 ◽

Cited By ~ 1

Author(s):

Inhwan Lee ◽

Eunmi Park ◽

Jinkyung Cho

Keyword(s):

Older Adults ◽

Vitamin D ◽

Liver Disease ◽

Physical Fitness ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Serum Vitamin ◽

Nonalcoholic Fatty Liver ◽

Serum Vitamin D ◽

Vitamin D Levels

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1295 SERUM VITAMIN D IS INVERSELY ASSOCIATED WITH NONALCOHOLIC FATTY LIVER DISEASE IN GENERAL POPULATION

Journal of Hepatology ◽

10.1016/s0168-8278(12)61307-5 ◽

2012 ◽

Vol 56 ◽

pp. S511 ◽

Cited By ~ 1

Author(s):

D. Kim ◽

G.E. Chung ◽

S.H. Lim ◽

J.Y. Yim ◽

M.J. Park ◽

...

Keyword(s):

Vitamin D ◽

Liver Disease ◽

General Population ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Serum Vitamin ◽

Nonalcoholic Fatty Liver ◽

Serum Vitamin D

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Sunlight Has Cardiovascular Benefits Independently of Vitamin D

Blood Purification ◽

10.1159/000441266 ◽

2016 ◽

Vol 41 (1-3) ◽

pp. 130-134 ◽

Cited By ~ 31

Author(s):

Richard B. Weller

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Risk Factor ◽

Serum Vitamin ◽

Sun Exposure ◽

High Serum ◽

Serum Vitamin D ◽

Life Years ◽

Vitamin D Levels ◽

All Cause Mortality

Background: High blood pressure (BP) is the leading risk factor for disability adjusted life years lost globally. Epidemiological data show a correlation between increased sun exposure and reduced population BP and cardiovascular mortality. Individuals with high serum vitamin D levels are at reduced risk of hypertension, cardiovascular disease and metabolic syndrome, yet multiple trial data show that oral vitamin D supplementation has no effect on these endpoints. Sunlight is a risk factor for skin cancers, but no link has been shown with increased all-cause mortality. Cohort studies from Scandinavia show a dose-dependent fall in mortality with increased sun-seeking behaviour. Skin contains significant stores of nitrogen oxides, which can be converted to NO by UV radiation and exported to the systemic circulation. Human studies show that this pathway can cause arterial vasodilatation and reduced BP. Murine studies suggest the same mechanism may reduce metabolic syndrome. Summary: Sunlight has beneficial effects on cardiovascular risk factors independently of vitamin D. Key Messages: All-cause mortality should be the primary determinant of public health messages. Sunlight is a risk factor for skin cancer, but sun avoidance may carry more of a cost than benefit for overall good health.

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