EVIDENCE FOR TISSUE-SPECIFIC REGULATION OF CALBINDIN 28K GENE EXPRESSION IN THE CHICK BY 1,25-DIHYDROXYVITAMIN D3.

Vitamin D ◽  
1988 ◽  
pp. 531-532
Keyword(s):  
Gene Expression ◽  
Dihydroxyvitamin D3 ◽  
Tissue Specific ◽  
1,25 Dihydroxyvitamin D3 ◽  
Specific Regulation

Tissue-Specific Regulation of Renin-Binding Protein Gene Expression in Rats1

1992 ◽  
Vol 112 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Masazumi Tada ◽  
Saori Takahashi ◽  
Motoshige Miyano ◽  
Yoshihiro Miyake
Keyword(s):  
Gene Expression ◽  
Protein Gene ◽  
Binding Protein ◽  
Tissue Specific ◽  
Binding Protein Gene ◽  
Specific Regulation

The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression

2013 ◽  
Vol 40 (12) ◽  
pp. 6685-6690 ◽  
Author(s):  
Lyudmila V. Dergunova ◽  
Alexandra V. Rozhkova ◽  
Olga Yu. Sudarkina ◽  
Svetlana A. Limborska
Keyword(s):  
Gene Expression ◽  
Alternative Polyadenylation ◽  
Tissue Specific ◽  
Specific Regulation

scholarly journals Cloning and characterization of the rat bone sialoprotein gene promoter

1993 ◽  
Vol 289 (3) ◽  
pp. 625-629 ◽  
Author(s):  
J J Li ◽  
J Sodek
Keyword(s):  
Gene Promoter ◽  
Bone Sialoprotein ◽  
Regulation Of Transcription ◽  
Flanking Sequence ◽  
Dihydroxyvitamin D3 ◽  
Tissue Specific ◽  
1,25 Dihydroxyvitamin D3 ◽  
Tata Element ◽  
Ccaat Box ◽  
Rat Bone

To study the transcriptional regulation of the rat bone sialoprotein (BSP) gene, the nucleotide sequence of a approximately 1 kb HindIII/KpnI subfragment from a genomic clone containing the 5′ flanking sequence, exon 1 and part of intron 1 was determined and the transcription start site defined. This region includes an inverted TATA element (nt -24 to -19), an inverted CCAAT box, a homeobox-binding site, a putative 1,25-dihydroxyvitamin D3 response element (VDRE) sequence overlapping the inverted TATA sequence, and a novel 18 nt palindrome that may control the tissue-specific transcription of the BSP gene. The shortest promoter sequence capable of directing bacterial chloramphenicol acetyltransferase reporter gene expression included the inverted TATA element and the inverted CCAAT box. However, the promoter activity was down-regulated by 1,25-dihydroxyvitamin D3, indicating that the unique VDRE-like sequence overlapping the TATA element is functional. Thus the rat BSP gene promoter is characterized by novel cis-acting elements that may be involved in hormone- and tissue-specific regulation of transcription.

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