RELEVANCE OF LONG-TERM VARIATION IN VITAMIN D METABOLITE MEASUREMENTS. IMPLICATIONS FOR LONGITUDINAL STUDY DESIGN.

Vitamin D ◽  
1988 ◽  
pp. 735-736
Keyword(s):  
Vitamin D ◽  
Longitudinal Study ◽  
Study Design ◽  
Term Variation ◽  
Longitudinal Study Design

Proposal for Levels of Evidence Schema for Validation of a Soluble Biomarker Reflecting Damage Endpoints in Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis, and Recommendations for Study Design

2009 ◽  
Vol 36 (8) ◽  
pp. 1792-1799 ◽  
Author(s):  
WALTER P. MAKSYMOWYCH ◽  
OLIVER FITZGERALD ◽  
GEORGE A. WELLS ◽  
DAFNA D. GLADMAN ◽  
ROBERT LANDEWÉ ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Longitudinal Study ◽  
Psoriatic Arthritis ◽  
Ankylosing Spondylitis ◽  
Study Design ◽  
Validation Studies ◽  
Working Group ◽  
Statistical Strength ◽  
Levels Of Evidence ◽  
Longitudinal Study Design

Objective.At OMERACT 8 a framework for levels of evidence was proposed for the validation of biomarkers as surrogate outcome measures. We aimed to adapt this scheme in order to apply it in the setting of soluble biomarkers proposed to replace the measurement of damage endpoints in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS). We also aimed to generate consensus on minimum standards for the design of longitudinal studies aimed at validating biomarkers.Methods.Before the meeting, the Soluble Biomarker Working Group prepared a preliminary framework and discussed various models for association and prediction related to the statistical strength domain. In addition, 3 Delphi exercises addressing longitudinal study design for RA, PsA, and AS were conducted within the working group and members of the Assessments in SpondyloArthritis International Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). This formed the basis for discussions among OMERACT 9 participants.Results.The proposed framework was accepted by consensus. In the study design domain a requirement for both prospective observational studies and randomized controlled trials (RCT) in different drug classes was noted. A template for determining the level of statistical strength was proposed. The addition of a new domain on biomarker assay performance was considered essential, and participants suggested that for any biomarker this domain should be addressed first, i.e., before starting clinical validation studies. Participants agreed on most elements of a longitudinal study design template. Where consensus was lacking the working group has drafted solutions that constitute a basis for prospective validation studies.Conclusion.The OMERACT 9 Soluble Biomarker Group has successfully formulated a levels of evidence scheme and a study design template that will provide guidance to conduct validation studies in the setting of soluble biomarkers proposed to replace the measurement of damage endpoints in RA, PsA, and AS.

scholarly journals Factors Contributing to Unwanted birth in India: Evidence from Longitudinal Study Design

2021 ◽  
Author(s):  
ANJALI BANSAL ◽  
Laxmi kant dwivedi ◽  
Priyanka Dixit
Keyword(s):  
Longitudinal Study ◽  
Study Design ◽  
Health Development ◽  
Unwanted Birth ◽  
Indian Health ◽  
Longitudinal Study Design

The data is used from the two rounds of Indian Health Development survey and we calculated the unwanted births from the two rounds of the survey.

PROMIS pediatric measures validated in a longitudinal study design in pediatric oncology

2019 ◽  
Vol 66 (5) ◽  
pp. e27606 ◽  
Author(s):  
Pamela S. Hinds ◽  
Jichuan Wang ◽  
Yao I. Cheng ◽  
Emily Stern ◽  
Mia Waldron ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Study Design ◽  
Pediatric Oncology ◽  
Longitudinal Study Design

scholarly journals Factors Contributing to Unwanted birth in India: Evidence from Longitudinal Study Design

2021 ◽  
Author(s):  
ANJALI BANSAL ◽  
Laxmi kant dwivedi ◽  
Priyanka Dixit
Keyword(s):  
Longitudinal Study ◽  
Study Design ◽  
Health Development ◽  
Unwanted Birth ◽  
Indian Health ◽  
Longitudinal Study Design

The data is used from the two rounds of Indian Health Development survey and we calculated the unwanted births from the two rounds of the survey.

scholarly journals Offspring of mothers with depression show asymmetric frontal brain activity

2018 ◽  
Keyword(s):  
Longitudinal Study ◽  
Study Design ◽  
Brain Activity ◽  
Frontal Brain ◽  
Longitudinal Study Design

These findings highlight the importance of a longitudinal study design in delineating the role of FA in depression.

scholarly journals Consistency and reliability of smoking-related variables: longitudinal study design in asthma and COPD

2019 ◽  
Vol 6 (1) ◽  
pp. 1591842 ◽  
Author(s):  
Eveliina Hirvonen ◽  
Mikhail Stepanov ◽  
Maritta Kilpeläinen ◽  
Ari Lindqvist ◽  
Tarja Laitinen
Keyword(s):  
Longitudinal Study ◽  
Study Design ◽  
Longitudinal Study Design
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