Anti-Inflammatory Effect of Pre-Elafin in Lipopolysaccharide-Induced Acute Lung Inflammation

2002 ◽  
Vol 383 (7-8) ◽  
Author(s):  
E. Vachon ◽  
Y. Bourbonnais ◽  
C.D. Bingle ◽  
S. J. Rowe ◽  
M. F. Janelle ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Acute Lung Inflammation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Resveratrol exerts anti-inflammatory effect in lipopolysaccharide-induced lung inflammation via downregulation of antioxidant and inflammatory mediators

2021 ◽  
Vol 17 (74) ◽  
pp. 275
Author(s):  
Xiaoming CHi ◽  
Xinxin Liang ◽  
Jian Shen ◽  
Xueming Duan ◽  
Rongbing Zhou ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Lung Inflammation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Vanillin protects lipopolysaccharide-induced acute lung injury by inhibiting ERK1/2, p38 and NF-κB pathway

2019 ◽  
Vol 11 (16) ◽  
pp. 2081-2094 ◽  
Author(s):  
Tingting Guo ◽  
Zhenzhong Su ◽  
Qi Wang ◽  
Wei Hou ◽  
Junyao Li ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Western Blot ◽  
Lung Inflammation ◽  
Macrophage Activation ◽  
Myeloperoxidase Activity ◽  
Histopathological Changes ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Aim: Thus far, the anti-inflammatory effect of vanillin in acute lung injury (ALI) has not been studied. This study aimed to investigate the effect of vanillin in lipopolysaccharide (LPS)-induced ALI. Results & methodology: Our study detected the anti-inflammatory effects of vanillin by ELISA and western blot, respectively. Pretreatment of mice with vanillin significantly attenuated LPS-stimulated lung histopathological changes, myeloperoxidase activity and expression levels of proinflammatory cytokines by inhibiting the phosphorylation activities of ERK1/2, p38, AKT and NF-κB p65. In addition, vanillin inhibited LPS-induced TNF-α and IL-6 expression in RAW264.7 cells via ERK1/2, p38 and NF-κB signaling. Conclusion: Vanillin can inhibit macrophage activation and lung inflammation, which suggests new insights for clinical treatment of ALI.

scholarly journals Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement

2013 ◽  
Vol 110 (13) ◽  
pp. 5205-5210 ◽  
Author(s):  
T. Murata ◽  
K. Aritake ◽  
Y. Tsubosaka ◽  
T. Maruyama ◽  
T. Nakagawa ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Signal Enhancement ◽  
Acute Lung Inflammation ◽  
Therapeutic Application ◽  
Anti Inflammatory

Action of anti-inflammatory agents on endotoxin-induced lung inflammation in mice

1959 ◽  
Vol 197 (4) ◽  
pp. 803-807 ◽  
Author(s):  
Ernest C. Herrmann ◽  
Claire Engle ◽  
Preston L. Perlman
Keyword(s):  
Escherichia Coli ◽  
Blood Vessel ◽  
Lung Inflammation ◽  
Lung Weight ◽  
Vessel Permeability ◽  
Anti Inflammatory ◽  
Inflammatory System ◽  
Modest Effect ◽  
Inflammatory Effect ◽  
Severe Lung

The instillation of Escherichia coli endotoxin (lipopolysaccharide) intranasally into mice produced severe lung lesions and a substantial increase in lung weight. Lung inflammation was maximal about 3 days after endotoxin instillation. Intraperitoneal injection of prednisone, cortisone and hydrocortisone sharply suppressed the lung inflammation. Five milligrams of prednisone produced a maximal anti-inflammatory effect when injected 24 and 48 hours after the endotoxin. Administration of large doses of Butazolidin also produced a modest effect on the lung inflammation. It is suggested that locally applied endotoxin alters blood vessel permeability of the lungs, resulting in hemorrhage, edema and exudation. The anti-inflammatory steroids reverse or inhibit this effect, perhaps by maintaining the integrity of the capillaries. Possible use and significance of this experimental anti-inflammatory system is discussed.

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