Resveratrol exerts anti-inflammatory effect in lipopolysaccharide-induced lung inflammation via downregulation of antioxidant and inflammatory mediators

2021 ◽  
Vol 17 (74) ◽  
pp. 275
Author(s):  
Xiaoming CHi ◽  
Xinxin Liang ◽  
Jian Shen ◽  
Xueming Duan ◽  
Rongbing Zhou ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Lung Inflammation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Inhibition of the pro-inflammatory mediators’ production and anti-inflammatory effect of the iridoid scrovalentinoside

2007 ◽  
Vol 110 (3) ◽  
pp. 419-427 ◽  
Author(s):  
Esperanza Bas ◽  
M. Carmen Recio ◽  
Mohamed Abdallah ◽  
Salvador Máñez ◽  
Rosa M. Giner ◽  
...  
Keyword(s):  
Inflammatory Mediators ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Vanillin protects lipopolysaccharide-induced acute lung injury by inhibiting ERK1/2, p38 and NF-κB pathway

2019 ◽  
Vol 11 (16) ◽  
pp. 2081-2094 ◽  
Author(s):  
Tingting Guo ◽  
Zhenzhong Su ◽  
Qi Wang ◽  
Wei Hou ◽  
Junyao Li ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Western Blot ◽  
Lung Inflammation ◽  
Macrophage Activation ◽  
Myeloperoxidase Activity ◽  
Histopathological Changes ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Aim: Thus far, the anti-inflammatory effect of vanillin in acute lung injury (ALI) has not been studied. This study aimed to investigate the effect of vanillin in lipopolysaccharide (LPS)-induced ALI. Results & methodology: Our study detected the anti-inflammatory effects of vanillin by ELISA and western blot, respectively. Pretreatment of mice with vanillin significantly attenuated LPS-stimulated lung histopathological changes, myeloperoxidase activity and expression levels of proinflammatory cytokines by inhibiting the phosphorylation activities of ERK1/2, p38, AKT and NF-κB p65. In addition, vanillin inhibited LPS-induced TNF-α and IL-6 expression in RAW264.7 cells via ERK1/2, p38 and NF-κB signaling. Conclusion: Vanillin can inhibit macrophage activation and lung inflammation, which suggests new insights for clinical treatment of ALI.

scholarly journals Anti-inflammatory effect of Sinhyowoldo-san Extract with regard to Pro-inflammatory Mediators in PMA plus A23187-induced Human Mast Cells

2014 ◽  
Vol 29 (6) ◽  
pp. 117-123
Author(s):  
Gyeong Wi ◽  
Da-Wun Yang ◽  
Ok-Hwa Kang ◽  
Sung-Bae Kim ◽  
Su-Hyun Mun ◽  
...  
Keyword(s):  
Mast Cells ◽  
Inflammatory Mediators ◽  
Human Mast Cells ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-Inflammatory Effect of Lycii radicis in LPS-Stimulated RAW 264.7 Macrophages

2014 ◽  
Vol 42 (04) ◽  
pp. 891-904 ◽  
Author(s):  
Mi Young Song ◽  
Hyo Won Jung ◽  
Seok Yong Kang ◽  
Kyung-Ho Kim ◽  
Yong-Ki Park
Keyword(s):  
Inflammatory Cytokines ◽  
Inflammatory Mediators ◽  
Water Extract ◽  
Inhibitory Effect ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Root Bark ◽  
Lycium Barbarum ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The root bark of Lycium barbarum (Lycii radicis cortex, LRC) is used as a cooling agent for fever and night sweats in East Asian traditional medicine. The inhibitory effect of LRC water extract on inflammation is unknown. In this study, the anti-inflammatory effect of LRC was investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage, RAW 264.7 cells. LRC extract significantly decreased the LPS-induced production of inflammatory mediators, nitric oxide (NO), prostaglandin (PG) E2 and pro-inflammatory cytokines, interleukin (IL)-1β and IL-6 in the cells. In addition, LRC extract inhibited the LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, and inflammatory cytokines mRNA in the cells. The action mechanism of LRC underlies the blocking of LPS-mediated p38 and Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPKs), and the nuclear factor (NF)-κB signaling pathway. These results indicate that LRC extract inhibits the inflammatory response in activated macrophages by down-regulating the transcription levels of inflammatory mediators and blocking the MAPKs and NF-κB pathway.

Action of anti-inflammatory agents on endotoxin-induced lung inflammation in mice

1959 ◽  
Vol 197 (4) ◽  
pp. 803-807 ◽  
Author(s):  
Ernest C. Herrmann ◽  
Claire Engle ◽  
Preston L. Perlman
Keyword(s):  
Escherichia Coli ◽  
Blood Vessel ◽  
Lung Inflammation ◽  
Lung Weight ◽  
Vessel Permeability ◽  
Anti Inflammatory ◽  
Inflammatory System ◽  
Modest Effect ◽  
Inflammatory Effect ◽  
Severe Lung

The instillation of Escherichia coli endotoxin (lipopolysaccharide) intranasally into mice produced severe lung lesions and a substantial increase in lung weight. Lung inflammation was maximal about 3 days after endotoxin instillation. Intraperitoneal injection of prednisone, cortisone and hydrocortisone sharply suppressed the lung inflammation. Five milligrams of prednisone produced a maximal anti-inflammatory effect when injected 24 and 48 hours after the endotoxin. Administration of large doses of Butazolidin also produced a modest effect on the lung inflammation. It is suggested that locally applied endotoxin alters blood vessel permeability of the lungs, resulting in hemorrhage, edema and exudation. The anti-inflammatory steroids reverse or inhibit this effect, perhaps by maintaining the integrity of the capillaries. Possible use and significance of this experimental anti-inflammatory system is discussed.

Molecular mechanisms of the effects of the ethanolic extract of Muntingia calabura Linn. fruit on lipopolysaccharide-induced pro-inflammatory mediators in macrophages

2017 ◽  
Vol 8 (3) ◽  
pp. 1245-1253 ◽  
Author(s):  
Jau-Tien Lin ◽  
Yuan-Yen Chang ◽  
Yi-Chen Chen ◽  
Bo-Yan Shen ◽  
Deng-Jye Yang
Keyword(s):  
Inflammatory Mediators ◽  
Molecular Mechanisms ◽  
Ethanolic Extract ◽  
Anti Inflammatory ◽  
Muntingia Calabura ◽  
Inflammatory Effect

The anti-inflammatory effect and mechanisms ofM. calaburaLinn. fruit.

Anti-Inflammatory Effect of Pre-Elafin in Lipopolysaccharide-Induced Acute Lung Inflammation

2002 ◽  
Vol 383 (7-8) ◽  
Author(s):  
E. Vachon ◽  
Y. Bourbonnais ◽  
C.D. Bingle ◽  
S. J. Rowe ◽  
M. F. Janelle ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Acute Lung Inflammation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Novel Analgesics with Peripheral Targets

2020 ◽  
Vol 17 (3) ◽  
pp. 784-825
Author(s):  
Cosmin I. Ciotu ◽  
Michael J. M. Fischer
Keyword(s):  
Sensory Neurons ◽  
Inflammatory Mediators ◽  
Inflammatory Process ◽  
Early Stage ◽  
Cellular Level ◽  
Proinflammatory Mediators ◽  
Inflammation Targeting ◽  
Anti Inflammatory ◽  
Current Stage ◽  
Inflammatory Effect

Abstract A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory process, of which an analgesic effect secondary to an anti-inflammatory effect can be expected. Different approaches to address these systems are discussed, including scavenging proinflammatory mediators, applying anti-inflammatory mediators, and inhibiting proinflammatory or facilitating anti-inflammatory receptors. New approaches are contrasted to established ones; the current stage of progress is mentioned, in particular considering whether there is data from a molecular and cellular level, from animals, or from human trials, including an early stage after a market release. An overview of publication activity is presented, considering a IuPhar/BPS-curated list of targets with restriction to pain-related publications, which was also used to identify topics.

scholarly journals Studies on the Anti-Inflammatory Effect and Its Mechanisms of Sophoridine

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Xiumei Huang ◽  
Bo Li ◽  
Lianzhong Shen
Keyword(s):  
Cell Culture ◽  
Inflammatory Response ◽  
Inflammatory Mediators ◽  
Culture Supernatant ◽  
Cell Culture Supernatant ◽  
In Vitro Cell Culture ◽  
Anti Inflammatory ◽  
Inflammatory Effect

This work is to study the anti-inflammatory effect and its mechanisms of sophoridine in vitro and in vivo. For this aim, the influences of sophoridine on several inflammatory mediators were investigated. Excessive inflammatory response in vitro model was developed by using lipopolysaccharide (LPS) to stimulate the mouse peritoneal macrophages and HL-60 cells to produce IL-6 and IL-8. Carrageenin-induced mouse paw edema model was used as inflammatory response in vivo model. MTT method, ultraviolet spectrophotometric method, and radioimmunoassay were used to measure the changes of TNFα, IL-6, PGE2, and IL-8 in in vitro cell culture supernatant or in the local inflammatory exudates. The results showed that sophoridine inhibited the production of IL-8 in in vitro cell culture supernatant and inhibited the production of TNFα, PGE2, and IL-8 in the local inflammatory exudates but had no significant effects on the production of IL-6 in vitro and in vivo. It is demonstrated that sophoridine’s anti-inflammatory effect was due to its ability to inhibit the production of cytokine and inflammatory mediators.

Sign in / Sign up

Export Citation Format

Share Document