Algorithm on age partitioning for estimation of reference intervals using clinical laboratory database exemplified with plasma creatinine

2018 ◽  
Vol 56 (9) ◽  
pp. 1514-1523 ◽  
Author(s):  
Xiaoxia Peng ◽  
Yaqi Lv ◽  
Guoshuang Feng ◽  
Yaguang Peng ◽  
Qiliang Li ◽  
...  

Abstract Background: We describe an algorithm to determine age-partitioned reference intervals (RIs) exemplified for creatinine using data collection from the clinical laboratory database. Methods: The data were acquired from the test results of creatinine of 164,710 outpatients aged <18 years in Beijing Children’s Hospital laboratories’ databases between January 2016 and December 2016. The tendency of serum creatinine with age was examined visually using box plot by gender first. The age subgroup was divided automatically by the decision tree method. Subsequently, the statistical tests of the difference between subgroups were performed by Harris-Boyd and Lahti methods. Results: A total of 136,546 samples after data cleaning were analyzed to explore the partition of age group for serum creatinine from birth to 17 years old. The suggested age partitioning of RIs for creatinine by the decision tree method were for eight subgroups. The difference between age subgroups was demonstrated to be statistically significant by Harris-Boyd and Lahti methods. In addition, the results of age partitioning for RIs estimation were similar to the suggested age partitioning by the Canadian Laboratory Initiative in Pediatric Reference Intervals study. Lastly, a suggested algorithm was developed to provide potential methodological considerations on age partitioning for RIs estimation. Conclusions: Appropriate age partitioning is very important for establishing more accurate RIs. The procedure to explore the age partitioning using clinical laboratory data was developed and evaluated in this study, and will provide more opinions for designing research on establishment of RIs.

1982 ◽  
Vol 28 (8) ◽  
pp. 1735-1741 ◽  
Author(s):  
J C Boyd ◽  
D A Lacher

Abstract We have developed a multi-stage computer algorithm to transform non-normally distributed data to a normal distribution. This transformation is of value for calculation of laboratory reference intervals and for normalization of clinical laboratory variates before applying statistical procedures in which underlying data normality is assumed. The algorithm is able to normalize most laboratory data distributions with either negative or positive coefficients of skewness or kurtosis. Stepwise, a logarithmic transform removes asymmetry (skewness), then a Z-score transform and power function transform remove residual peakedness or flatness (kurtosis). Powerful statistical tests of data normality in the procedure help the user evaluate both the necessity for and the success of the data transformation. Erroneous assessments of data normality caused by rounded laboratory test values have been minimized by introducing computer-generated random noise into the data values. Reference interval endpoints that were estimated parametrically (mean +/- 2 SD) by using successfully transformed data were found to have a smaller root-mean-squared error than those estimated by the non-parametric percentile technique.


2014 ◽  
Vol 6 (1) ◽  
pp. 9-14
Author(s):  
Stefanie Sirapanji ◽  
Seng Hansun

Beauty is a precious asset for everyone. Everyone wants to have a healthy face. Unfortunately, there are always those problems that pops out on its own. For example, acnes, freckles, wrinkles, dull, oily and dry skin. Therefore, nowadays, there are a lot of beauty clinics available to help those who wants to solve their beauty troubles. But, not everyone can enjoy the facilities of those beauty clinics, for example those in the suburbs. The uneven distribution of doctors and the expensive cost of treatments are some of the reasons. In this research, the system that could help the patients to find the solution of their beauty problems is built. The decision tree method is used to take decision based on the shown schematic. Based on the system’s experiment, the average accuracy level hits 100%. Index Terms–Acnes, Decision Tree, Dry Skin, Dull, Facial Problems, Freckles, Wrinkles, Oily Skin, Eexpert System.


2013 ◽  
Vol 774-776 ◽  
pp. 1757-1761
Author(s):  
Bing Xiang Liu ◽  
Xu Dong Wu ◽  
Ying Xi Li ◽  
Xie Wei Wang

This paper takes more than four hundred records of some cable television system for example, makes data mining according to users data record, uses BP neural network and decision tree method respectively to have model building and finds the best model fits for users to order press service. The results of the experiment validate the methods feasibility and validity.


2011 ◽  
Vol 403-408 ◽  
pp. 1804-1807
Author(s):  
Ning Zhao ◽  
Shao Hua Dong ◽  
Qing Tian

In order to optimize electric- arc welding (ERW) welded tube scheduling , the paper introduces data cleaning, data extraction and transformation in detail and defines the datasets of sample attribute, which is based on analysis of production process of ERW welded tube. Furthermore, Decision-Tree method is adopted to achieve data mining and summarize scheduling rules which are validated by an example.


Author(s):  
Hananda Hafizan ◽  
Anggita Nadia Putri

One of the health problems in Indonesia is the problem of nutritional status of children under five years. Cases of malnutrition are not only a family problem, but also a state problem. The nutritional status of children under five years can be assessed by measuring the human body known as "Anthropometry". To be able to carry out anthropometric examinations and measurements in order to find out the nutritional status of children under five, they can go to public health service places such as the Posyandu. We went to the KENANGA Posyandu located in Wonorejo, Kerasaan sub-district, Simalungun district. The purpose of this study will be to test the model for the classification of nutritional status of children under the WHO-2005 reference standard by utilizing data mining techniques using the Decision Tree method C4.5 Algorithm.


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