Human Heart-Type Cytoplasmic Fatty Acid-Binding Protein (H-FABP) for the Diagnosis of Acute Myocardial Infarction. Clinical Evaluation of H-FABP in Comparison with Myoglobin and Creatine Kinase Isoenzyme MB

2000 ◽  
Vol 38 (3) ◽  
Author(s):  
Fumio Okamoto ◽  
Koichi Sohmiya ◽  
Yasuhiko Ohkaru ◽  
Keishiro Kawamura ◽  
Kumiko Asayama ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Fatty Acid ◽  
Human Heart ◽  
Fatty Acid Binding Protein ◽  
Fatty Acid Binding ◽  
Creatine Kinase Isoenzyme ◽  
Acid Binding Protein ◽  
Creatine Kinase Isoenzyme Mb

Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction

1991 ◽  
Vol 24 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Takao Tanaka ◽  
Yuzo Hirota ◽  
Koh-Ichi Sohmiya ◽  
Sinzo Nishimura ◽  
Keishiro Kawamura
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Human Heart ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Serum concentrations of myoglobin vs human heart-type cytoplasmic fatty acid-binding protein in early detection of acute myocardial infarction

1997 ◽  
Vol 43 (8) ◽  
pp. 1372-1378 ◽  
Author(s):  
Junnichi Ishii ◽  
Jian-hua Wang ◽  
Hiroyuki Naruse ◽  
Shinn Taga ◽  
Masatomo Kinoshita ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Early Diagnosis ◽  
Healthy Volunteers ◽  
Human Heart ◽  
Fatty Acid Binding Protein ◽  
Serum Concentrations ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Abstract We compared the diagnostic utility of serum concentrations of human heart-type cytoplasmic fatty acid-binding protein (H-FABPc), myoglobin, and their ratio for the early diagnosis of acute myocardial infarction (AMI) in 104 healthy volunteers and 165 patients at admission within 6 h of the onset of chest pain. The ROC curves of the H-FABPc [0.946, 95% confidence interval (CI) = 0.913–0.979] and myoglobin (0.895, 95% CI = 0.846–0.944) between patients with AMI and healthy volunteers were significantly greater than the area under the ratio of myoglobin to H-FABPc (0.823, 95% CI = 0.765–0.881). In 165 patients, the sensitivity (81.8%, 95% CI = 74.2–89.4%), specificity (86.4%, 95% CI = 78.1–94.6%), and predictive accuracy (83.6%, 95% CI = 78.0–89.3%) of H-FABPc >12 μg/L in diagnosing AMI were significantly higher than those of myoglobin, and were similar to those of the combination of H-FABPc >12 μg/L and the ratio ≤14. We conclude that H-FABPc is a more sensitive and specific marker than myoglobin for the early diagnosis of AMI, and that their ratio cannot give a clear advantage over the measurement of H-FABPc alone.

Human heart-type cytoplasmic fatty acid-binding protein as an indicator of acute myocardial infarction

1995 ◽  
Vol 10 (6) ◽  
pp. 304-309 ◽  
Author(s):  
Kenro Yoshimoto ◽  
Takao Tanaka ◽  
Kohichi Somiya ◽  
Ryoichi Tsuji ◽  
Fumio Okamoto ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Fatty Acid ◽  
Human Heart ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
Sign in / Sign up

Export Citation Format

Share Document