Regioselective alkylation of 1,2,4-triazole using ionic liquids under microwave conditions
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Abstract1-Substituted 1,2,4-triazole derivatives present in a large number of compounds and display a variety of bioactivities such as antibiotic, anti-inflammatory, anti-diabetic, antipsychotic, and anticancer. A regioselective protocol has been developed for the alkylation of 1,2,4- triazole using mild conditions. The 1-alkyl-1,2,4-triazole derivatives were synthesized under microwave conditions using potassium carbonate as a base and ionic liquid (hexylpyridinium bromide) as a solvent. The products were obtained in excellent yield, and the base-ionic liquid combination was recycled for a number of times.
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2014 ◽
Vol 989-994
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pp. 676-679
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2012 ◽
Vol 476-478
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pp. 2621-2624
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2005 ◽
Vol 2005
(9)
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pp. 613-616
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2019 ◽
Vol 15
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pp. 2907-2913
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Green Synthesis of Liquid Crystal Intermediates the Preparation of Phenylacetylenes in Ionic Liquids
2010 ◽
Vol 428-429
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pp. 46-51
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