scholarly journals In-flow enantioselective homogeneous organic synthesis

2021 ◽  
Vol 10 (1) ◽  
pp. 768-778
Author(s):  
Alessandra Puglisi ◽  
Sergio Rossi ◽  
Fabian Herbrik ◽  
Fabrizio Medici ◽  
Maurizio Benaglia

Abstract The use of enabling technologies, such as flow reactors, three-dimensional-printed devices, and electrochemistry, in the stereoselective synthesis of enantioenriched compounds is presented, with a special focus on the most significant contributions to the field reported in the last few years.

2021 ◽  
Vol 11 (12) ◽  
pp. 5461
Author(s):  
Elmedin Mešić ◽  
Enis Muratović ◽  
Lejla Redžepagić-Vražalica ◽  
Nedim Pervan ◽  
Adis J. Muminović ◽  
...  

The main objective of this research is to establish a connection between orthodontic mini-implant design, pull-out force and primary stability by comparing two commercial mini-implants or temporary anchorage devices, Tomas®-pin and Perfect Anchor. Mini-implant geometric analysis and quantification of bone characteristics are performed, whereupon experimental in vitro pull-out test is conducted. With the use of the CATIA (Computer Aided Three-dimensional Interactive Application) CAD (Computer Aided Design)/CAM (Computer Aided Manufacturing)/CAE (Computer Aided Engineering) system, 3D (Three-dimensional) geometric models of mini-implants and bone segments are created. Afterwards, those same models are imported into Abaqus software, where finite element models are generated with a special focus on material properties, boundary conditions and interactions. FEM (Finite Element Method) analysis is used to simulate the pull-out test. Then, the results of the structural analysis are compared with the experimental results. The FEM analysis results contain information about maximum stresses on implant–bone system caused due to the pull-out force. It is determined that the core diameter of a screw thread and conicity are the main factors of the mini-implant design that have a direct impact on primary stability. Additionally, stresses generated on the Tomas®-pin model are lower than stresses on Perfect Anchor, even though Tomas®-pin endures greater pull-out forces, the implant system with implemented Tomas®-pin still represents a more stressed system due to the uniform distribution of stresses with bigger values.


ChemInform ◽  
2006 ◽  
Vol 37 (50) ◽  
Author(s):  
Gareth P. Wild ◽  
Charlotte Wiles ◽  
Paul Watts

2020 ◽  
Vol 64 (01) ◽  
pp. 23-47
Author(s):  
Robinson Peric ◽  
Moustafa Abdel-Maksoud

This article reviews different types of forcing zones (sponge layers, damping zones, relaxation zones, etc.) as used in finite volume-based flow simulations to reduce undesired wave reflections at domain boundaries, with special focus on the case of strongly reflecting bodies subjected to long-crested incidence waves. Limitations and possible sources of errors are discussed. A novel forcing-zone arrangement is presented and validated via three-dimensional (3D) flow simulations. Furthermore, a recently published theory for predicting the forcing-zone behavior was investigated with regard to its relevance for practical 3D hydrodynamics problems. It was found that the theory can be used to optimally tune the case-dependent parameters of the forcing zones before running the simulations. 1. Introduction Wave reflections at the boundaries of the computational domain can cause significant errors in flow simulations, and must therefore be reduced. In contrast to boundary element codes, where much progress in this respect has been made decades ago (see e.g., Clement 1996; Grilli &Horillo 1997), for finite volume-based flow solvers, there are many unresolved questions, especially:How to reliably reduce reflections and disturbances from the domain boundaries?How to predict the amount of undesired wave reflection before running the simulation? This work aims to provide further insight to these questions for flow simulations based on Navier-Stokes-type equations (Reynolds-averaged Navier-Stokes, Euler equations, Large Eddy Simulations, etc.), when using forcing zones to reduce undesired reflections. The term "forcing zones" is used here to describe approaches that gradually force the solution in the vicinity of the boundary towards some reference solution, as described in Section 2; some examples are absorbing layers, sponge layers, damping zones, relaxation zones, or the Euler overlay method (Mayer et al. 1998; Park et al. 1999; Chen et al. 2006; Choi &Yoon 2009; Jacobsen et al. 2012; Kimet al. 2012; Schmitt & Elsaesser 2015; Perić & Abdel-Maksoud 2016a; Vukčević et al. 2016).


Micromachines ◽  
2022 ◽  
Vol 13 (1) ◽  
pp. 80
Author(s):  
Xiaohu Zhou ◽  
Han Wu ◽  
Haotian Wen ◽  
Bo Zheng

Single-cell analysis is becoming an indispensable tool in modern biological and medical research. Single-cell isolation is the key step for single-cell analysis. Single-cell printing shows several distinct advantages among the single-cell isolation techniques, such as precise deposition, high encapsulation efficiency, and easy recovery. Therefore, recent developments in single-cell printing have attracted extensive attention. We review herein the recently developed bioprinting strategies with single-cell resolution, with a special focus on inkjet-like single-cell printing. First, we discuss the common cell printing strategies and introduce several typical and advanced printing strategies. Then, we introduce several typical applications based on single-cell printing, from single-cell array screening and mass spectrometry-based single-cell analysis to three-dimensional tissue formation. In the last part, we discuss the pros and cons of the single-cell strategies and provide a brief outlook for single-cell printing.


Author(s):  
F. W. Liou

Abstract Due to the current advances in simulation, computer graphics, robotics, and other related technologies, virtual environment has become a future trend in design and development of new products. This paper summarizes the current enabling technologies to develop a virtual environment for parts handling applications, such as parts feeding, assembling, and robotic grasping. A special focus is on developing a physically-based simulation system, which is the core of a virtual parts handling environment. Critical technologies such as object collision detection and response, contact modeling and friction modeling are reviewed. The technological challenges in these areas are also pointed out.


Author(s):  
Achala V. Dassanayake ◽  
C. Steve Suh

A three dimensional dynamic model describing turning operation involving whirling caused by mass imbalance is presented. Both the workpiece and tool deflections affected by nonlinear regenerative forces with instantaneous cutting speed and feed are included. The work piece is modeled as a system of three rotors; namely, unmachined, being machined and machined, connected by a flexible shaft. Special focus is given to the middle rotor where cutting forces act and the new surface is being generated. The nonlinear behavior of the system is studied using instantaneous frequency. The stable and unstable situations are illustrated in time domain as well as time-frequency domain. Models with and without whirling are considered and two sets of results are compared with the experimental results published in the literature.


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