Anti-inflammatory and immunomodulatory activities of Inula cappa roots (Compositae)

AbstractBackgroundThe medicinal properties ofMethodsAnti-inflammatory and immunomodulatory activities ofResultsThe methanolic extract showed maximum reduction in the rat paw edema and showed significant inhibition of the cotton pellet-induced granulomas in rats. The methanolic extract also showed potential immunomodulatory activity in all the assays performed. Two sesquiterpenes, isoalantolactone and germacranolide were also isolated from the methanolic extract.ConclusionsThe present study supports the evidence that the roots of

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Leaves of Stereospermum suaveolens DC Exhibit Anti-inflammatory and Anti-arthritic Potential Action in Experimental Animals

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i33a31783 ◽

2021 ◽

pp. 164-175

Author(s):

R. R. Chanshetti ◽

D. D. Bandawane

Keyword(s):

Ethyl Acetate ◽

Methanolic Extract ◽

Research Work ◽

Ethyl Acetate Fraction ◽

Significant Inhibition ◽

Paw Edema ◽

Standard Drug ◽

Rat Paw Edema ◽

Anti Inflammatory ◽

Rat Paw

Aim: The experimental investigation of current research work was to identify traditional rich claim of Stereospermum suaveolens DC leaves for anti-inflammatory and anti-arthritic potential action in animals. Study design: Ethyl acetate fraction of Stereospermum suaveolens DC (Bignoniaceae) methanolic extract of leaves evaluated at 125mg/kg, 250mg/kg and 500mg/kg (p.o.) doses for anti-inflammatory and anti-arthritic activity. Methodology: Ethyl acetate fraction of Stereospermum suaveolens DC (Bignoniaceae) methanolic extract of leaves was evaluated for phytochemical investigation for total flavonoid content using UV spectroscopy and TLC study. Carrageenan induced rat paw edema (Acute method) and Freund’s complete adjuvant (FCA) induced chronic arthritis in wistar rats were used as an animal models to claim Stereospermum suaveolens DC leaves for anti-inflammatory and anti-arthritic potential. The rat paw volume and percentage inhibition of the paw edema were evaluated for anti-inflammatory activity. The assessments of arthritis in rats were measured by haematological values and radiological examinations. Result: Ethyl acetate fraction of Stereospermum suaveolens DC (Bignoniaceae) methanolic extract of leaves showed presence of total flavonoids and saponins. The significant inhibition in paw volume and edema (p < .01) obtained at 250mg/kg and 500mg/kg oral dose. These obtained results were established confirmation outcome for presence of rich flavonoid contents in Stereospermum suaveolens DC leaves and provides valuable source of bioactive phytocomponents. Conclusion: Ethyl acetate fraction of Stereospermum suaveolens DC (Bignoniaceae) methanolic extract of leaves showed significant inhibition of inflammatory reaction as compared to standard drug indomethacin Sterospermum Suaveolens DC leaves were showed potential therapeutic role in treatment of inflammation and arthritis cases.

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Anti-inflammatory Activity of Pistacia lentiscus Essential Oil: Involvement of IL-6 and TNF-α

Natural Product Communications ◽

10.1177/1934578x1100601033 ◽

2011 ◽

Vol 6 (10) ◽

pp. 1934578X1100601 ◽

Cited By ~ 2

Author(s):

Andrea Maxia ◽

Cinzia Sanna ◽

Maria Assunta Frau ◽

Alessandra Piras ◽

Manvendra Singh Karchuli ◽

...

Keyword(s):

Essential Oil ◽

Inflammatory Activity ◽

Pistacia Lentiscus ◽

Paw Edema ◽

Rat Paw Edema ◽

Tnf Α ◽

Cotton Pellet ◽

Anti Inflammatory ◽

Factor Α ◽

Rat Paw

The topical anti-inflammatory activity of essential oil of Pistacia lentiscus L. was studied using carrageenan induced rat paw edema and cotton pellet induced granuloma. The effect on serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats inserted with cotton pellet was also investigated. On topical application, the oil exhibited a significant decrease in paw edema. The oil also inhibited cotton pellet-induced granuloma, and reduced serum TNF-α and IL-6. It can be concluded that the essential oil of Pistacia lentiscus reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.

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ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT FROM JATROPHA CURCAS (EUPHORBIACEAE) LEAVES ON EXPERIMENTAL ANIMALS

INDIAN DRUGS ◽

10.53879/id.50.08.p0032 ◽

2013 ◽

Vol 50 (08) ◽

pp. 32-38

Author(s):

P Chandra ◽

◽

N Sachan ◽

R Yadav ◽

K. Kishore ◽

...

Keyword(s):

Jatropha Curcas ◽

Pain Threshold ◽

Methanolic Extract ◽

Paw Edema ◽

Traditional Use ◽

Analgesic Effects ◽

Rat Paw Edema ◽

Anti Inflammatory ◽

Analgesic Activities ◽

Rat Paw

The present study evaluates the analgesic and anti-inflammatory activities of the methanolic extract from Jatropha curcas (Euphorbiaceae) leaves to provide experimental evidence for its traditional use. Investigations on the analgesic effects and anti-inflammatory activities of J. curcas were carried out by utilizing the different animal models. It has been shown that the methanolic extract from Jatropha curcas leaves significantly increased pain threshold and reduced writhing response as well as inhibited the increase in vascular permeability. Also, it significantly decreased the carrageenan-induced rat paw edema. The results show that the methanolic extract from Jatropha curcas leaves have both central and peripheral analgesic activities and as anti-inflammatory effects, supporting the traditional application of this herb in treating various diseases associated with inflammation and pain.

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STUDY OF ANTI-INFLAMMATORY ACTIVITY OF CASSIA AURICULATA LINN. LEAVES IN WISTAR RATS

INDIAN DRUGS ◽

10.53879/id.49.11.p0044 ◽

2012 ◽

Vol 49 (11) ◽

pp. 44-47

Author(s):

A. A. Mali ◽

◽

M. G Hivrale ◽

D. D. Bandawane ◽

P. D Chaudhari

Keyword(s):

Ethyl Acetate ◽

Wistar Rats ◽

Methanolic Extract ◽

Inflammatory Activity ◽

Paw Edema ◽

Cassia Auriculata ◽

Rat Paw Edema ◽

Anti Inflammatory ◽

Rat Paw ◽

Pharmacological Model

The present study was undertaken to evaluate the anti-inflammatory activity of aqueous, methanolic, ethyl acetate and hydroalcoholic extracts of Cassia auriculata leaves. The study was carried out using the pharmacological model of carrageenan induced rat paw edema. Among all extracts methanolic extract showed maximum anti-inflammatory potential. Indomethacin (10mg/kg) was used as referencec ompound in the present study. The anti-inflammatory activity of methanolic extract may be due to presence alkaloids, flavonoids, tannins and steroids.

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EVALUATION OF ANTI-INFLAMMATORY (IN VIVO) ACTIVITY OF ARIFLEX LINIMENT IN COMPARISON WITH DICLOFENAC GEL IN CARRAGEENAN INDUCED RAT PAW EDEMA MODEL

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2021v13i4.42747 ◽

2021 ◽

pp. 67-70

Author(s):

SANJAY NIPANIKAR ◽

S. S. CHITLANGE

Keyword(s):

Significant Inhibition ◽

Lateral Malleolus ◽

Inflammatory Activity ◽

Control Group ◽

Paw Edema ◽

Rat Paw Edema ◽

Edema Model ◽

Anti Inflammatory ◽

Rat Paw

Objective: The present study was conducted to evaluate anti-inflammatory activity of Ariflex liniment (conceptualized and developed by Ari Healthcare Pvt. Ltd) in comparison with Diclofenac gel in carrageenan induced rat paw edema model. Methods: Wistar rats of either sex weighing 150-180 g were taken and divided into 3 groups with 6 animals in each group i.e. Group 1 (Controlled Group), Group 2 (Diclofenac gel) and Group 3 (Ariflex liniment). The study drugs were topically applied 30 min prior to carrageenan injection. After 30 min 1% w/v of 0.05 ml carrageenan was injected subcutaneously in the paw. The paw was marked with ink at the level of lateral malleolus and immersed in mercury up to the lateral malleolus mark. The paw volume was measured plethysmographically, immediately after injection i.e. on 0 min, and then on 30 min,1h, 2h,3h, 4h and 5hr after injection. Results: Diclofenac gel sodium treated group showed significant inhibition (p<0.01) of paw edema at 30 min, 1, 2, 3, 4 and 5th hrs as compared to control group. Ariflex Liniment showed significant inhibition (p<0.05) of paw edema at 30 min, 1, 2, 3, and 4th hrs as compared to the control group. Group treated with Ariflex Liniment did not show any significant decrease in paw edema volume at 5th hrs when compared to the control group. Conclusion: Ariflex Liniment possesses anti-inflammatory activity.

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Anti-inflammatory effect of leaves of Vernonia zeylanica in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced rat paw-edema model

Journal of Ethnopharmacology ◽

10.1016/j.jep.2021.114030 ◽

2021 ◽

pp. 114030

Author(s):

Dilani Rukshala ◽

E. Dilip de Silva ◽

B.V.Loshini R. Ranaweera ◽

Narmada Fernando ◽

Shiroma M. Handunnetti

Keyword(s):

Raw 264.7 ◽

Paw Edema ◽

Raw 264.7 Macrophages ◽

Rat Paw Edema ◽

Edema Model ◽

Anti Inflammatory ◽

Rat Paw ◽

Inflammatory Effect

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Retraction Note: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Inflammation ◽

10.1007/s10753-020-01359-x ◽

2020 ◽

Author(s):

Sachin S. Sakat ◽

Kamaraj Mani ◽

Yulia O. Demidchenko ◽

Evgeniy A. Gorbunov ◽

Sergey A. Tarasov ◽

...

Keyword(s):

Paw Edema ◽

Rat Paw Edema ◽

Edema Model ◽

Anti Inflammatory ◽

Rat Paw ◽

Inflammatory Effect

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Anti-Inflammatory Activity of Chrozophora rottleri Extracts on Carrageenan-Induced Rat Paw Edema

International Journal of Pharmacology Phytochemistry and Ethnomedicine ◽

10.18052/www.scipress.com/ijppe.3.20 ◽

2016 ◽

Vol 3 ◽

pp. 20-26

Author(s):

Mallikarjuna Rao Talluri ◽

Battu Ganga Rao ◽

Y. Venkateswaea Rao

Keyword(s):

Ethyl Acetate ◽

Methanol Extract ◽

Bioactive Molecules ◽

Inflammatory Activity ◽

Paw Edema ◽

Standard Drug ◽

Isolation And Characterization ◽

Rat Paw Edema ◽

Anti Inflammatory ◽

Rat Paw

The present study was intended to evaluate Anti-inflammatory activity ofC. rottleriextracts (Hydroalcoholic, Methanol, Ethyl acetate and Hexane). The Anti-inflammatory activity ofC.rottleriextracts at doses of 125mg/kg, 250mg/kg and 500mg/kg using carrageenan induced rat paw edema model compared with standard drug (Indomethacin). The selected plant extracts significantly inhibited paw edema along with the standard drug Indomethacin. Of all extracts, methanol extract produced significant effect on reduction of increased paw thickness, hydro alcoholic and ethyl acetate extracts produced moderate percentage inhibition and hexane extract produced low level of percentage inhibition in reducing paw edema on carrageenan induced rats. In all extracts, methanol extract at a dose of 500mg/kg showed more percentage inhibition i.e . 53.47±2.19. From the results obtained during the study it is concluded thatC. rottlerihaving the bioactive molecule responsible for Anti-inflammatory activity by individually or by combination of different bio-active compounds present in it. Further is necessary for isolation and characterization of bioactive molecules which are responsible for the selected plant biological activities.

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