Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of the late preterm delivery regardless of the membrane status

Abstract Objectives To compare the immunohistochemical expression of IL-6 in placental membranes of late preterm delivery in women with histologically proven chorioamnionitis with and without preterm premature rupture of membranes (PPROM). Methods Fetal membranes were collected from 60 women who had late preterm delivery with histologic chorioamnionitis with and without PPROM (30 in each group). Immunohistochemistry for IL-6 was performed on formalin fixed and paraffin-embedded sections. The two groups were matched for age, body mass index and parity. SPSS Version 17.0 was used for statistical analysis. Results There was no difference in immunohistochemical expression of IL-6 in placental membranes of women with histologic chorioamnionitis regardless of the membrane status. Conclusions Chorioamnionitis has no impact on immunohistochemical expression of IL-6 in placental membranes of women with late preterm delivery despite the clinical presentation.

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Acute Histologic Chorioamnionitis Is a Risk Factor for Adverse Neonatal Outcome in Late Preterm Birth after Preterm Premature Rupture of Membranes

PLoS ONE ◽

10.1371/journal.pone.0079941 ◽

2013 ◽

Vol 8 (12) ◽

pp. e79941 ◽

Cited By ~ 23

Author(s):

Seung Mi Lee ◽

Jeong Woo Park ◽

Byoung Jae Kim ◽

Chan-Wook Park ◽

Joong Shin Park ◽

...

Keyword(s):

Risk Factor ◽

Preterm Birth ◽

Neonatal Outcome ◽

Late Preterm ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Adverse Neonatal Outcome ◽

Preterm Premature Rupture ◽

Late Preterm Birth ◽

Histologic Chorioamnionitis

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469: Quantitative fetal fibronectin screening at 24 weeks delineates the risk of spontaneous preterm delivery in asymptomatic patients with a prior history of preterm premature rupture of membranes (PPROM)

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2009.10.635 ◽

2009 ◽

Vol 201 (6) ◽

pp. S177 ◽

Cited By ~ 1

Author(s):

James Kurtzman ◽

Manju Chandiramani ◽

Annette Briley ◽

Lucilla Poston ◽

Anita Das ◽

...

Keyword(s):

Preterm Delivery ◽

Prior History ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Fetal Fibronectin ◽

Preterm Premature Rupture ◽

Spontaneous Preterm Delivery ◽

Asymptomatic Patients ◽

History Of

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Risk Factors for Neonatal Bronchopulmonary Dysplasia in Extremely Preterm Premature Rupture of Membranes: A Retrospective Study

10.21203/rs.3.rs-35635/v3 ◽

2020 ◽

Author(s):

Eishin Nakamura ◽

Shigetaka Matsunaga ◽

Yoshihisa Ono ◽

Yasushi Takai ◽

Hiroyuki Seki

Keyword(s):

Risk Factors ◽

Preterm Delivery ◽

Bronchopulmonary Dysplasia ◽

Roc Curve ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Extremely Preterm ◽

Gestational Week ◽

The Mean

Abstract Background: Determination of the optimal timing for termination of pregnancy in cases of preterm premature rupture of membranes (pPROM) during the extremely preterm period is still difficult. Bronchopulmonary dysplasia (BPD) is a major disease widely taken into account when determining the prognosis of respiratory disorders in a neonate. Many aspects of this disease remain unclear. With the aim of further improving the prognosis of neonates born to mothers with pPROM, this study examined cases who were diagnosed with pPROM before 28 weeks of gestation. The study analysed risk factors for neonatal BPD. Methods: This study included 73 subjects with singleton pregnancy, diagnosed with pPROM during the gestational period from 22 weeks and 0 days to 27 weeks and 6 days. The following factors were retrospectively examined: the gestational week at which pPROM was diagnosed, the gestational week at which delivery occurred, the period for which the volume of amniotic fluid was maintained, and neonatal BPD as a complication. Receiver operating characteristic (ROC) curve analyses were conducted to analyse the relationship of the onset of BPD with the duration of oligohydramnios and the gestational weeks of delivery. Results: The mean gestational week at which a diagnosis of amniorrhexis was made was 24.5±1.9 weeks (mean±SD), and that at which delivery occurred was 27.0±3.0 weeks. Fifty-seven cases (78.1%) were diagnosed with oligohydramnios, the mean duration of which was 17.4±20.5 days. The mean birth weight of neonates was 1000±455 g, of which 49 (67.1%) were diagnosed with BPD following birth. No neonates died in this study. The ROC curve indicated that the cut-off values for the duration of oligohydramnios and gestational age at delivery were 4 days and 24.1 weeks, respectively. Multivariate analysis indicated that the duration of oligohydramnios for more than 4 days before delivery and preterm delivery at less than 24.1 weeks were risk factors for the onset of BPD. Conclusion: Our findings suggest that duration of oligohydramnios for more than 4 days before delivery and preterm delivery less than 24.1 weeks are risk factors for BPD in cases who are diagnosed with pPROM before 28 weeks of gestation.

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A case of severe SARS-CoV-2 infection with negative nasopharyngeal PCR in pregnancy

Case Reports in Perinatal Medicine ◽

10.1515/crpm-2020-0075 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Anna Fuchs ◽

Lauren Harris ◽

Ashley Huber ◽

Mia Heiligenstein ◽

Cassandra Heiselman ◽

...

Keyword(s):

Clinical Presentation ◽

Clinical Status ◽

Igg Antibodies ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Case Presentation ◽

Preterm Premature Rupture ◽

High Clinical Suspicion ◽

Maternal Status

Abstract Objectives SARS-CoV-2 remains a pressing issue for our obstetric community during the current pandemic. We present a case of a 22-year-old nulliparous woman 31 weeks pregnant, with significant clinical SARS-CoV-2 disease, in the setting of negative nasopharyngeal PCR testing but positive IgG antibodies. Case presentation This was a 22-year-old patient 31 weeks pregnant who presented with fever, tachycardia, and subsequently preterm premature rupture of membranes (PPROM) and pulmonary emboli with multifocal pneumonia. The patient underwent three negative SARS-CoV-2 tests via nasopharyngeal PCR testing during her hospital stay as well as a negative workup for fever. After a cesarean section for worsening maternal status after 7 days of hospitalization, the patient was admitted for worsening clinical status to the SICU. At the time of SICU admission patient was found to have serum IgG positive antibodies and was managed with intubation, antibiotics, and anticoagulation. Patient eventually left hospital against medical advice on hospital day 16 on oral antibiotics but was found to be recovering well at later outpatient follow up. Conclusions Diagnosis of SARS-CoV-2 remains a complicated picture in the setting of testing limitations. This case highlights an antepartum clinical presentation of severe SARS-CoV-2 and recommends a high clinical suspicion for diagnosis of SARS-CoV-2 and initiation of treatment in the pregnant population, even in the presence of negative nasopharyngeal PCR testing.

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Fetal Fibronectin in Cervical and Vaginal Secretions as a Predictor of Preterm Delivery

50 Studies Every Obstetrician-Gynecologist Should Know ◽

10.1093/med/9780190947088.003.0009 ◽

2021 ◽

pp. 48-53

Author(s):

Zachary Colvin ◽

Anna Palatnik

Keyword(s):

England Journal ◽

New England ◽

Preterm Delivery ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Fetal Fibronectin ◽

Preterm Premature Rupture ◽

Vaginal Secretions

This article reviews the study “Fetal Fibronectin in Cervical and Vaginal Secretions as a Predictor of Preterm Delivery,” published in The New England Journal of Medicine in 1991 by Lockwood et al. The study examined the use of fetal fibronectin found in cervicovaginal secretions as a marker for preterm delivery in symptomatic women presenting with preterm contractions or with preterm premature rupture of membranes. The chapter reviews the findings of this study as well as the place of fetal fibronectin testing in current obstetrical practice based on subsequent studies.

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