scholarly journals Visfatin/Pre-B cell colony-enhancing factor in amniotic fluid in normal pregnancy, spontaneous labor at term, preterm labor and prelabor rupture of membranes: an association with subclinical intrauterine infection in preterm parturition

2008 ◽  
Vol 36 (6) ◽  
Author(s):  
Shali Mazaki-Tovi ◽  
Roberto Romero ◽  
Juan Pedro Kusanovic ◽  
Offer Erez ◽  
Francesca Gotsch ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
B Cell ◽  
Preterm Labor ◽  
Intrauterine Infection ◽  
Normal Pregnancy ◽  
Enhancing Factor ◽  
Prelabor Rupture Of Membranes ◽  
Cell Colony

scholarly journals Local downregulation of pre-B cell colony-enhancing factor/visfatin using an adeno-associated virus type 5 vector encoding a specific small hairpin RNA for PBEF results in amelioration of arthritis

2011 ◽  
Vol 70 (Suppl 2) ◽  
pp. A77-A77
Author(s):  
L. Bevaart ◽  
D. Kyburz ◽  
J. Koepke ◽  
F. Brentano ◽  
N. Broekstra ◽  
...  
Keyword(s):  
B Cell ◽  
Virus Type ◽  
Hairpin Rna ◽  
Adeno Associated Virus ◽  
Small Hairpin Rna ◽  
Enhancing Factor ◽  
Cell Colony

scholarly journals Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor.

1994 ◽  
Vol 14 (2) ◽  
pp. 1431-1437 ◽  
Author(s):  
B Samal ◽  
Y Sun ◽  
G Stearns ◽  
C Xie ◽  
S Suggs ◽  
...  
Keyword(s):  
Stem Cell ◽  
B Cell ◽  
Stem Cell Factor ◽  
Human Peripheral Blood ◽  
Biological Activities ◽  
In Vitro Assays ◽  
Pokeweed Mitogen ◽  
Interleukin 7 ◽  
Enhancing Factor ◽  
Cell Colony

A novel gene coding for the pre-B-cell colony-enhancing factor (PBEF) has been isolated from a human peripheral blood lymphocyte cDNA library. The expression of this gene is induced by pokeweed mitogen and superinduced by cycloheximide. It is also induced in the T-lymphoblastoid cell line HUT 78 after phorbol ester (phorbol myristate acetate) treatment. The predominant mRNA for PBEF is approximately 2.4 kb long and codes for a 52-kDa secreted protein. The 3' untranslated region of the mRNA has multiple TATT motifs, usually found in cytokine and oncogene messages. The PBEF gene is mainly transcribed in human bone marrow, liver tissue, and muscle. We have expressed PBEF in COS 7 and PA317 cells and have tested the biological activities of the conditioned medium as well as the antibody-purified protein in different in vitro assays. PBEF itself had no activity but synergized the pre-B-cell colony formation activity of stem cell factor and interleukin 7. In the presence of PBEF, the number of pre-B-cell colonies was increased by at least 70% above the amount stimulated by stem cell factor plus interleukin 7. No effect of PBEF was found with cells of myeloid or erythroid lineages. These data define PBEF as a novel cytokine which acts on early B-lineage precursor cells.

scholarly journals Elevated Plasma Level of Visfatin/Pre-B Cell Colony-Enhancing Factor in Patients with Type 2 Diabetes Mellitus

2006 ◽  
Vol 91 (1) ◽  
pp. 295-299 ◽  
Author(s):  
Miao-Pei Chen ◽  
Fu-Mei Chung ◽  
Dao-Ming Chang ◽  
Jack C.-R. Tsai ◽  
Han-Fen Huang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Level ◽  
B Cell ◽  
Elevated Plasma ◽  
Enhancing Factor ◽  
Cell Colony

Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine

2008 ◽  
Vol 115 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Grit Sommer ◽  
Antje Garten ◽  
Stefanie Petzold ◽  
Annette G. Beck-Sickinger ◽  
Matthias Blüher ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
B Cell ◽  
Hormonal Regulation ◽  
Physiological Role ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Insulin Mimetic ◽  
Enzymatic Function ◽  
Enhancing Factor ◽  
Structure Regulation ◽  
Cell Colony

Over the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF (pre-B-cell colony-enhancing factor) has recently been identified as a novel adipokine with insulin-mimetic effects. Furthermore, an enzymatic function has been reported that reveals visfatin/PBEF as Nampt (nicotinamide phosphoribosyltransferase; EC 2.4.2.12.). Moreover, reports on the structure and hormonal regulation of visfatin/PBEF/Nampt have given further insights into its potential physiological role. The present review summarizes studies on visfatin/PBEF/Nampt as a novel adipokine.

Pre-B-cell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation

2005 ◽  
Vol 70 (3) ◽  
pp. 142-151 ◽  
Author(s):  
Shui Q. Ye ◽  
Li Q. Zhang ◽  
Djanybek Adyshev ◽  
Peter V. Usatyuk ◽  
Alexander N. Garcia ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
B Cell ◽  
Enhancing Factor ◽  
Cell Colony

Pre-B-cell colony-enhancing factor, a novel cytokine of human fetal membranes

2002 ◽  
Vol 187 (4) ◽  
pp. 1051-1058 ◽  
Author(s):  
Simona Ognjanovic ◽  
Gillian D. Bryant-Greenwood
Keyword(s):  
B Cell ◽  
Fetal Membranes ◽  
Enhancing Factor ◽  
Cell Colony

scholarly journals Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes

2020 ◽  
Vol 48 (2) ◽  
pp. 115-131 ◽  
Author(s):  
Kevin R. Theis ◽  
Roberto Romero ◽  
Kenichiro Motomura ◽  
Jose Galaz ◽  
Andrew D. Winters ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Ribosomal Rna ◽  
Preterm Labor ◽  
Rrna Gene ◽  
Inflammasome Activation ◽  
Amniotic Cavity ◽  
Valuable Complement ◽  
Polymerase Chain ◽  
Adverse Pregnancy ◽  
Prelabor Rupture Of Membranes

Abstract Background Intra-amniotic inflammation, which is associated with adverse pregnancy outcomes, can occur in the presence or absence of detectable microorganisms, and involves activation of the inflammasome. Intra-amniotic inflammasome activation has been reported in clinical chorioamnionitis at term and preterm labor with intact membranes, but it has not yet been investigated in women with preterm prelabor rupture of membranes (preterm PROM) in the presence/absence of detectable microorganisms. The aim of this study was to determine whether, among women with preterm PROM, there is an association between detectable microorganisms in amniotic fluid and intra-amniotic inflammation, and whether intra-amniotic inflammasome activation correlates with microbial burden. Methods Amniotic fluids from 59 cases of preterm PROM were examined for the presence/absence of microorganisms through culture and 16S ribosomal RNA (rRNA) gene quantitative real-time polymerase chain reaction (qPCR), and concentrations of interleukin-6 (IL-6) and ASC [apoptosis-associated spec-like protein containing a caspase recruitment domain (CARD)], an indicator of inflammasome activation, were determined. Results qPCR identified more microbe-positive amniotic fluids than culture. Greater than 50% of patients with a negative culture and high IL-6 concentration in amniotic fluid yielded a positive qPCR signal. ASC concentrations were greatest in patients with high qPCR signals and elevated IL-6 concentrations in amniotic fluid (i.e. intra-amniotic infection). ASC concentrations tended to increase in patients without detectable microorganisms but yet with elevated IL-6 concentrations (i.e. sterile intra-amniotic inflammation) compared to those without intra-amniotic inflammation. Conclusion qPCR is a valuable complement to microbiological culture for the detection of microorganisms in the amniotic cavity in women with preterm PROM, and microbial burden is associated with the severity of intra-amniotic inflammatory response, including inflammasome activation.

scholarly journals Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions

2013 ◽  
Vol 24 (5) ◽  
pp. 433-442 ◽  
Author(s):  
Zhongjie Sun ◽  
Han Lei ◽  
Zhonge Zhang
Keyword(s):  
B Cell ◽  
Physiological Functions ◽  
Enhancing Factor ◽  
Cell Colony

Pre-B cell colony enhancing factor/NAMPT/visfatin and its role in inflammation-related bone disease

2010 ◽  
Vol 690 (1-2) ◽  
pp. 95-101 ◽  
Author(s):  
Alexander R. Moschen ◽  
Sabine Geiger ◽  
Romana Gerner ◽  
Herbert Tilg
Keyword(s):  
B Cell ◽  
Bone Disease ◽  
Enhancing Factor ◽  
Cell Colony

scholarly journals Nicotinamide Phosphoribosyl Transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin Is Required for Lymphocyte Development and Cellular Resistance to Genotoxic Stress

2008 ◽  
Vol 181 (7) ◽  
pp. 4685-4695 ◽  
Author(s):  
Anthony Rongvaux ◽  
Mara Galli ◽  
Sébastien Denanglaire ◽  
Frédéric Van Gool ◽  
Pierre L. Drèze ◽  
...  
Keyword(s):  
B Cell ◽  
Genotoxic Stress ◽  
Lymphocyte Development ◽  
Cellular Resistance ◽  
Phosphoribosyl Transferase ◽  
Enhancing Factor ◽  
Nicotinamide Phosphoribosyl Transferase ◽  
Cell Colony
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