Direct flow separation strategy, to isolate no-carrier-added 90Nb from irradiated Mo or Zr targets

90Nb has an intermediate half-life of 14.6 h, a high positron branching of 53% and optimal β+ emission energy of only Emean 0.35 MeV per decay. These favorable characteristics suggest it may be a potential candidate for application in immuno-PET. Our recent aim was to conduct studies on distribution coefficients for ZrIV and NbV in mixtures of HCl/H2O2 and HCl/oxalic acid for anion exchange resin (AG 1 × 8) and UTEVA resin to develop a “direct flow” separation strategy for 90Nb. The direct flow concept refers to a separation accomplished using a single eluent on multiple columns, effectively streamlining the separation process and increasing the time efficiency. Finally, we also demonstrated that this separation strategy is applicable to the production of the positron emitter 90Nb via the irradiation of molybdenum targets and isolation of 90Nb from the irradiated molybdenum target.