Anticryptoccal Serum Factors in Experimental Liver Disease

1968 ◽  
Vol 23 (8) ◽  
pp. 1091-1095 ◽  
Author(s):  
Hans H. Gadebusch
Keyword(s):  
Liver Disease ◽  
Host Resistance ◽  
Potential Role ◽  
Hepatic Dysfunction ◽  
Liver Necrosis ◽  
Rat Serum ◽  
Serum Factors ◽  
Glycogen Deposition ◽  
Experimental Liver

Lysozyme and β-lysin activity in rat serum have been studied biochemically and microbiologically after induction of hepatic dysfunction. Under the conditions of these experiments β-lysin activity was adversely affected by liver necrosis or cirrhosis, while both factors (β-lysin ** and lysozyme) were affected by hyperbilirubinemia. Lysozyme and β-lysin activity were unaffected in serum from rats afflicted with (a) malnutrition, (b) fatty liver in the absence of significant necrosis, (c) disturbance in porphyrin metabolism as represented by hexachlorobenzene intoxication, and (d) extent of glycogen deposition in the liver.The potential role of these and other pertinent factors in host resistance to cryptoccosis has been discussed.

scholarly journals Liver Nodules after the Fontan Operation: Role of Magnetic Resonance Elastography

2015 ◽  
Vol 42 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Joseph T. Poterucha ◽  
Sudhakar K. Venkatesh ◽  
Jennifer L. Novak ◽  
Frank Cetta
Keyword(s):  
Magnetic Resonance ◽  
Potential Role ◽  
Screening Tool ◽  
Hepatic Dysfunction ◽  
Fontan Operation ◽  
Magnetic Resonance Elastography ◽  
Liver Nodules ◽  
Diagnostic Management ◽  
Fontan Palliation

Hepatic dysfunction after the Fontan surgical palliation runs an indolent course. Moreover, there is no standard method of evaluating hepatic dysfunction. Magnetic resonance elastography has emerged as an advanced screening tool for preclinical detection of hepatic fibrosis and cirrhosis. We describe the case of a patient who had undergone Fontan palliation, and then developed liver nodules and elevated tumor markers 18 years later. Her case illustrates the challenges in diagnostic management of hepatic dysfunction and the potential role of magnetic resonance elastography in monitoring these patients.

scholarly journals New view on alcoholic liver disease - potential role of PD1/PDL-1 pathway in the disease pathogenesis

2019 ◽  
Vol 9 (11) ◽  
pp. 121
Author(s):  
Katarzyna Adamczyk ◽  
Beata Kasztelan-Szczerbińska ◽  
Anna Rycyk ◽  
Halina Cichoż-Lach
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Potential Role ◽  
Disease Pathogenesis ◽  
New View

scholarly journals Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration

2021 ◽  
Vol 26 (5) ◽  
pp. 497-501
Author(s):  
Ellen Rootring ◽  
Cheryl L. Sargel ◽  
Joseph D. Tobias
Keyword(s):  
Potential Role ◽  
Hepatic Dysfunction ◽  
Esophageal Fistula ◽  
Prevention Strategies ◽  
Surgical Interventions ◽  
Button Battery ◽  
Acute Ingestion ◽  
Chronic Ingestion

Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The potential role of chronic acetaminophen administration in the etiology of hepatoxicity is discussed and prevention strategies are presented.

Hepatic dysfunction induced by intestinal dysbacteriosis mainly manifests as immunologic abnormity in mice

2020 ◽  
Vol 78 (6) ◽  
Author(s):  
Xia Luo ◽  
Bo Xu ◽  
Tianqin Xiong ◽  
Yulin Su ◽  
Chang liu ◽  
...  
Keyword(s):  
Potential Role ◽  
Hepatic Dysfunction ◽  
Intestinal Flora ◽  
Intestinal Wall ◽  
Mice Model ◽  
Intestinal Microbes ◽  
Transmission Electron ◽  
Tnf Α ◽  
Intestinal Dysbacteriosis

ABSTRACT Currently, the potential role of the alterations occurring in the liver immune system and intestinal flora in liver injury remains unknown. Our study aimed to explore the impacts of intestinal microbial barrier damage induced by ceftriaxone on liver immunity. We developed the BALB/c mice model by administering ceftriaxone. The intestinal microbial barrier damage was observed by 16S rRNA, and the pathological changes of intestines and livers were detected by H&E or transmission electron microscope. The activation of immunocytes were tested by Flow Cytometry; the expression of LPS, ALT, AST, IL-6 and TNF-α were detected by Limulus Test or ELISA. Compared to the control, the intestinal microbes significantly decreased in ceftriaxone group. Additionally, the weight of cecum contents increased, the intestinal wall became thinner and the villus in the small intestine and cecum were damaged. The expression of LPS and the ratio of liver lymphocytes were significantly increased. H&E results indicated the structures of liver arose the pathologic changes. Meanwhile, the content of serum ALT, AST, IL-6 and TNF-α increased. Collectively, our study indicates that the damages of gut microbial barrier induced by ceftriaxone prompted activation of immunocytes and release of inflammatory cytokines, which may lead to chronic inflammation in liver.

Erratum: Potential Role of Chitotriosidase Gene in Nonalcoholic Fatty Liver Disease Evolution

2012 ◽  
Vol 107 (12) ◽  
pp. 1932 ◽  
Author(s):  
Lucia Malaguarnera ◽  
Michelino D Rosa ◽  
Anna M Zambito ◽  
Nicola dellʼOmbra ◽  
Robert D Marco ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Potential Role ◽  
Disease Evolution ◽  
Nonalcoholic Fatty Liver

scholarly journals Compounds of the sphingomyelin-ceramide-glycosphingolipid pathways as secondary messenger molecules: new targets for novel therapies for fatty liver disease and insulin resistance

2016 ◽  
Vol 310 (11) ◽  
pp. G1102-G1117 ◽  
Author(s):  
Yaron Ilan
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Potential Role ◽  
Cell Organelles ◽  
Secondary Messenger ◽  
Pathological Conditions ◽  
Messenger Molecules

The compounds of sphingomyelin-ceramide-glycosphingolipid pathways have been studied as potential secondary messenger molecules in various systems, along with liver function and insulin resistance. Secondary messenger molecules act directly or indirectly to affect cell organelles and intercellular interactions. Their potential role in the pathogenesis of steatohepatitis and diabetes has been suggested. Data samples collected from patients with Gaucher's disease, who had high levels of glucocerebroside, support a role for compounds from these pathways as a messenger molecules in the pathogenesis of fatty liver disease and diabetes. The present review summarizes some of the recent data on the role of glycosphingolipid molecules as messenger molecules in various physiological and pathological conditions, more specifically including insulin resistance and fatty liver disease.

scholarly journals The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling

2020 ◽  
Vol 131 ◽  
pp. 110785
Author(s):  
Samukelisiwe C. Shabalala ◽  
Phiwayinkosi V. Dludla ◽  
Lawrence Mabasa ◽  
Abidemi P. Kappo ◽  
Albertus K. Basson ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Potential Role ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease
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