scholarly journals Liver Nodules after the Fontan Operation: Role of Magnetic Resonance Elastography

2015 ◽  
Vol 42 (4) ◽  
pp. 389-392 ◽  
Author(s):  
Joseph T. Poterucha ◽  
Sudhakar K. Venkatesh ◽  
Jennifer L. Novak ◽  
Frank Cetta
Keyword(s):  
Magnetic Resonance ◽  
Potential Role ◽  
Screening Tool ◽  
Hepatic Dysfunction ◽  
Fontan Operation ◽  
Magnetic Resonance Elastography ◽  
Liver Nodules ◽  
Diagnostic Management ◽  
Fontan Palliation

Hepatic dysfunction after the Fontan surgical palliation runs an indolent course. Moreover, there is no standard method of evaluating hepatic dysfunction. Magnetic resonance elastography has emerged as an advanced screening tool for preclinical detection of hepatic fibrosis and cirrhosis. We describe the case of a patient who had undergone Fontan palliation, and then developed liver nodules and elevated tumor markers 18 years later. Her case illustrates the challenges in diagnostic management of hepatic dysfunction and the potential role of magnetic resonance elastography in monitoring these patients.

scholarly journals The Role of Three‐Dimensional Magnetic Resonance Elastography in the Diagnosis of Nonalcoholic Steatohepatitis in Obese Patients Undergoing Bariatric Surgery

Hepatology ◽  
2019 ◽  
Vol 71 (2) ◽  
pp. 510-521 ◽  
Author(s):  
Alina M. Allen ◽  
Vijay H. Shah ◽  
Terry M. Therneau ◽  
Sudhakar K. Venkatesh ◽  
Taofic Mounajjed ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Magnetic Resonance ◽  
Nonalcoholic Steatohepatitis ◽  
Three Dimensional ◽  
Magnetic Resonance Elastography ◽  
Obese Patients

scholarly journals Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration

2021 ◽  
Vol 26 (5) ◽  
pp. 497-501
Author(s):  
Ellen Rootring ◽  
Cheryl L. Sargel ◽  
Joseph D. Tobias
Keyword(s):  
Potential Role ◽  
Hepatic Dysfunction ◽  
Esophageal Fistula ◽  
Prevention Strategies ◽  
Surgical Interventions ◽  
Button Battery ◽  
Acute Ingestion ◽  
Chronic Ingestion

Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The potential role of chronic acetaminophen administration in the etiology of hepatoxicity is discussed and prevention strategies are presented.

Hepatic dysfunction induced by intestinal dysbacteriosis mainly manifests as immunologic abnormity in mice

2020 ◽  
Vol 78 (6) ◽  
Author(s):  
Xia Luo ◽  
Bo Xu ◽  
Tianqin Xiong ◽  
Yulin Su ◽  
Chang liu ◽  
...  
Keyword(s):  
Potential Role ◽  
Hepatic Dysfunction ◽  
Intestinal Flora ◽  
Intestinal Wall ◽  
Mice Model ◽  
Intestinal Microbes ◽  
Transmission Electron ◽  
Tnf Α ◽  
Intestinal Dysbacteriosis

ABSTRACT Currently, the potential role of the alterations occurring in the liver immune system and intestinal flora in liver injury remains unknown. Our study aimed to explore the impacts of intestinal microbial barrier damage induced by ceftriaxone on liver immunity. We developed the BALB/c mice model by administering ceftriaxone. The intestinal microbial barrier damage was observed by 16S rRNA, and the pathological changes of intestines and livers were detected by H&E or transmission electron microscope. The activation of immunocytes were tested by Flow Cytometry; the expression of LPS, ALT, AST, IL-6 and TNF-α were detected by Limulus Test or ELISA. Compared to the control, the intestinal microbes significantly decreased in ceftriaxone group. Additionally, the weight of cecum contents increased, the intestinal wall became thinner and the villus in the small intestine and cecum were damaged. The expression of LPS and the ratio of liver lymphocytes were significantly increased. H&E results indicated the structures of liver arose the pathologic changes. Meanwhile, the content of serum ALT, AST, IL-6 and TNF-α increased. Collectively, our study indicates that the damages of gut microbial barrier induced by ceftriaxone prompted activation of immunocytes and release of inflammatory cytokines, which may lead to chronic inflammation in liver.

scholarly journals Role of magnetic resonance elastography in compensated and decompensated liver disease

2014 ◽  
Vol 60 (5) ◽  
pp. 934-939 ◽  
Author(s):  
Sumeet K. Asrani ◽  
Jayant A. Talwalkar ◽  
Patrick S. Kamath ◽  
Vijay H. Shah ◽  
Giovanna Saracino ◽  
...  
Keyword(s):  
Liver Disease ◽  
Magnetic Resonance ◽  
Magnetic Resonance Elastography ◽  
Decompensated Liver Disease

scholarly journals Midwall Fibrosis: Cardiac Magnetic Resonance Imaging in Risk Stratifying Cardiomyopathies

2015 ◽  
Vol 9 (1) ◽  
pp. 89-90
Author(s):  
D.P. Ripley ◽  
P. Garg ◽  
A. Kotecha ◽  
O.E. Gosling ◽  
N.G. Bellenger
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Cardiac Magnetic Resonance Imaging ◽  
Potential Role ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Resonance Imaging ◽  
Management Challenge

The United Kingdom’s National Institute for Health and Care Excellence guidance on implantable cardiac defibrillator (ICD) therapy recommend ICD in those with left ventricular dysfunction and a high risk of sudden cardiac death (SCD). SCD accounts for 30% deaths in non-ischaemic dilated cardiomyopathy (DCM), however risk stratifying and predicting SCD in DCM is a major management challenge. We present two cases demonstrating the potential role of cardiac magnetic resonance imaging in risk stratifying DCM.

Hemiazygos vein “steal hypoxic-syndrome” after hemi-Fontan operation: comprehensive four-dimensional flow magnetic resonance visualisation

2012 ◽  
Vol 22 (4) ◽  
pp. 481-484 ◽  
Author(s):  
Israel Valverde ◽  
Aarthi Razishankar ◽  
Owen Miller ◽  
Reza Razavi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Fontan Operation ◽  
Left Heart ◽  
Resonance Imaging ◽  
Hypoplastic Left Heart ◽  
Non Invasive ◽  
Staged Surgery ◽  
Left Heart Syndrome ◽  
Fontan Palliation

AbstractA 2-year-old boy with hypoplastic left heart syndrome and previous hemi-Fontan palliation surgery was referred for cardiovascular magnetic resonance evaluation because of progressive cyanosis. This case report illustrates the advantages of non-invasive four-dimensional magnetic resonance imaging for comprehensive identification and quantification of venovenous collaterals in patients with palliated hemi-Fontan staged surgery.

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