Die Racemisierungs-Geschwindigkeit Schiffscher Basen von Aminosäure-estern / The Racemization of the Esters of N- (p-Nitrobenzylidene) -α-amino Acids

1971 ◽  
Vol 26 (8) ◽  
pp. 762-764 ◽  
Author(s):  
I. Z. Siemion ◽  
L. Wilschowitz
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Esters ◽  
Amino Acid Esters ◽  
Butyl Esters ◽  
Acid Esters

The racemization rate of N- [p-nitrobenzylidene] -α-amino acid esters was found to be even thousand-fold smaller than that of the azlactones of N-acyl-α-amino acids. t-Butyl esters of N-[p- nitrobenzylidene]-α-amino acids are much more stable to racemization as the correspondent methyl esters.

Chiral recognition of amino-acid esters by a glucose-derived macrocyclic receptor

2021 ◽  
Author(s):  
Pit Dominique ◽  
Martin Schnurr ◽  
Bartosz Lewandowski
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chiral Recognition ◽  
Methyl Esters ◽  
Aqueous Environment ◽  
Amino Acid Esters ◽  
Acid Methyl ◽  
Wide Range ◽  
Acid Esters ◽  
Amino Acid Methyl Esters

We report a glucose-based crown ether capable of chiral recognition of a wide range of amino-acid methyl esters in aqueous environment. The enantioselectivities towards amino-acids with extended hydrophobic side chains...

ChemInform Abstract: A SYNTHESIS OF N-PHTHALOYL AMINO ACIDS AND AMINO ACID ESTERS UNDER MILD CONDITIONS

1973 ◽  
Vol 4 (40) ◽  
pp. no-no
Author(s):  
D. A. HOOGWATER ◽  
D. N. REINHOUDT ◽  
T. S. LIE ◽  
J. J. GUNNEWEG ◽  
H. C. BEYERMAN
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Esters ◽  
Mild Conditions ◽  
Acid Esters

Nickel-catalyzed carbodifunctionalization of N-vinylamides enables access to γ-amino acids

2020 ◽  
Vol 56 (17) ◽  
pp. 2642-2645 ◽  
Author(s):  
Zhi-Fang Yang ◽  
Chang Xu ◽  
Xing Zheng ◽  
Xingang Zhang
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Tandem Reaction ◽  
Amino Acid Esters ◽  
Arylboronic Acids ◽  
Acid Esters

A nickel-catalyzed tandem reaction of N-vinylamides with arylboronic acids and bromodifluoroacetate has been developed. The reaction efficiently furnishes a series of protected α,α-difluoro-γ-amino acid esters.

The anti-leishmanial activity of dipeptide esters on Leishmania amazonensis amastigotes

Parasitology ◽  
1990 ◽  
Vol 100 (2) ◽  
pp. 201-207 ◽  
Author(s):  
C. Ramazeilles ◽  
L. Juliano ◽  
J. R. Chagas ◽  
M. Rabinovitch
Keyword(s):  
Amino Acid ◽  
Methyl Esters ◽  
Leishmania Amazonensis ◽  
Amino Acid Esters ◽  
Cysteine Proteinases ◽  
Hydrophobic Amino Acid ◽  
Structure Activity ◽  
Reduction Assay ◽  
Mtt Reduction ◽  
Acid Esters

SUMMARYL-Amino acid esters, such as L-Leu-OMe, kill Leishmania amazonensis amastigotes by a mechanism which appears to involve ester hydrolysis by cysteine proteinases located in the parasite megasomes. We have examined the killing of isolated amastigotes by L-dipeptide esters and derived some structure-activity correlations. Toxicity of the compounds for the parasites was measured by a tetrazolium (MTT) reduction assay. The results show that active dipeptide esters contained at least I hydrophobic amino acid (Leu, Ile, Val, Phe or Trp). The activity of homodipeptide methyl esters depended on the nature of the amino acid, as indicated by the following series: Phe-Phe-OMe < Val-Val-OMe < Leu-Leu-OMe < Trp-Trp-OMe < Ile-Ile-OMe. The nature of the amino acids in Leu-X-OMe and X-Leu-OMe was relatively unimportant when X was Phe, Trp or Val. However, when X was Ala or Gly, Leu-X-OMe was several-fold more active than X-Leu-OMe.

One-pot synthesis of 4-arylidene imidazolin-5-ones by reaction of amino acid esters with isocyanates and α-bromoketones

2019 ◽  
Vol 17 (11) ◽  
pp. 3040-3047
Author(s):  
Jia-Yun Haung ◽  
Indrajeet J. Barve ◽  
Chung-Ming Sun
Keyword(s):  
Amino Acid ◽  
Multicomponent Reaction ◽  
Methyl Esters ◽  
Amino Acid Esters ◽  
One Pot ◽  
One Pot Synthesis ◽  
Acid Methyl ◽  
Acid Esters ◽  
Amino Acid Methyl Esters

A one-pot multicomponent reaction for assembling substituted 4-arylidene imidazolin-5-ones from l-amino acid methyl esters, iso-, isothio- or isoselenocyanates, and α-bromoketones has been discovered.

scholarly journals The reactions of α-amino acids and α-amino acid esters with high valent transition metal halides: synthesis of coordination complexes, activation processes and stabilization of α-ammonium acylchloride cations

RSC Advances ◽  
2017 ◽  
Vol 7 (17) ◽  
pp. 10158-10174 ◽  
Author(s):  
Lorenzo Biancalana ◽  
Marco Bortoluzzi ◽  
Eleonora Ferretti ◽  
Mohammad Hayatifar ◽  
Fabio Marchetti ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Transition Metal ◽  
Transition Metals ◽  
Coordination Compounds ◽  
Coordination Complexes ◽  
Amino Acid Esters ◽  
Metal Halides ◽  
High Valent ◽  
Acid Esters

We describe the synthesis of rare coordination compounds of early transition metals with α-amino acids and α-amino acid esters, the unusual C–C dimerization ofl-proline, and the stabilization of reactive α-ammonium acylchloride cations.

A synthesis of N-phthaloyl amino acids and amino acid esters under mild conditions

2010 ◽  
Vol 92 (8) ◽  
pp. 819-825 ◽  
Author(s):  
D.A. Hoogwater ◽  
D.N. Reinhoudt ◽  
T.S. Lie ◽  
J.J. Gunneweg ◽  
H.C. Beyerman
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Amino Acid Esters ◽  
Mild Conditions ◽  
Acid Esters
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