Chiral recognition of amino-acid esters by a glucose-derived macrocyclic receptor

2021 ◽  
Author(s):  
Pit Dominique ◽  
Martin Schnurr ◽  
Bartosz Lewandowski
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chiral Recognition ◽  
Methyl Esters ◽  
Aqueous Environment ◽  
Amino Acid Esters ◽  
Acid Methyl ◽  
Wide Range ◽  
Acid Esters ◽  
Amino Acid Methyl Esters

We report a glucose-based crown ether capable of chiral recognition of a wide range of amino-acid methyl esters in aqueous environment. The enantioselectivities towards amino-acids with extended hydrophobic side chains...

One-pot synthesis of 4-arylidene imidazolin-5-ones by reaction of amino acid esters with isocyanates and α-bromoketones

2019 ◽  
Vol 17 (11) ◽  
pp. 3040-3047
Author(s):  
Jia-Yun Haung ◽  
Indrajeet J. Barve ◽  
Chung-Ming Sun
Keyword(s):  
Amino Acid ◽  
Multicomponent Reaction ◽  
Methyl Esters ◽  
Amino Acid Esters ◽  
One Pot ◽  
One Pot Synthesis ◽  
Acid Methyl ◽  
Acid Esters ◽  
Amino Acid Methyl Esters

A one-pot multicomponent reaction for assembling substituted 4-arylidene imidazolin-5-ones from l-amino acid methyl esters, iso-, isothio- or isoselenocyanates, and α-bromoketones has been discovered.

Destruction of intracellular and isolated Leishmania mexicana amazonensis amastigotes by amino acid amides

Parasitology ◽  
1988 ◽  
Vol 96 (2) ◽  
pp. 289-296 ◽  
Author(s):  
M. Rabinovitch ◽  
V. Zilberfarb
Keyword(s):  
Amino Acid ◽  
Methyl Ester ◽  
Methyl Esters ◽  
Hydrolytic Enzymes ◽  
Amino Acid Esters ◽  
Leishmania Mexicana ◽  
Acid Methyl ◽  
Hydrolysis Of ◽  
Acid Esters ◽  
Amino Acid Methyl Esters

SummaryL-amino acid esters such as leucine methyl ester (Leu-OMe) destroy Leishmania mexicana amazonensis amastigotes by a mechanism which may involve hydrolysis of the compounds by parasite enzymes. Moreover, several esters (e.g. Ile-OMe) prevent the killing of parasites by Leu-OMe, perhaps by inhibition of the hydrolytic enzymes. We show here that certain amino acid amides are also leishmanicidal. Killing of Leishmania within macrophages was assessed microscopically, and that of isolated amastigotes was measured by reduction of the tetrazolium MTT. Amino acid amides were generally less active than the methyl esters and several were more toxic to the macrophages, as determined by inspection of Giemsa-stained preparations. Ranks of activity of the amides on isolated amastigotes were Trp > Leu > Phe > Met > Tyr. The amides of Ala, Gly, Val, Ile, His and D-Leu were inactive. This pattern of activity is similar to that of amino acid methyl esters. Ile-NH2 and a few other amides protected intracellular as well as isolated parasites from killing by Leu-OMe. Conversely, Ile-OMe reduced the toxicity of Leu-NH2 for isolated amastigotes. None of the esters or amides assayed prevented the destruction of Leishmania by Trp-NH2. The results are compatible with the view that amino acid esters and amides may be recognized by the same or similar parasite enzymes.

Multifunctional lubricant additives derived from natural amino acids and methyl oleate

RSC Advances ◽  
2015 ◽  
Vol 5 (95) ◽  
pp. 77538-77544 ◽  
Author(s):  
Arukali Sammaiah ◽  
Korlipara V. Padmaja ◽  
Shiva Shanker Kaki ◽  
Rachapudi B. N. Prasad
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Oleate ◽  
Thioglycolic Acid ◽  
Methyl Esters ◽  
Lubricant Additives ◽  
Acid Methyl ◽  
Multifunctional Additives ◽  
Natural Amino Acids ◽  
Amino Acid Methyl Esters

Novel multifunctional additives were synthesized from methyl oleate via thioglycolic acid addition followed by condensation with different amino acid methyl esters.

The Resolution of Amino Acids by Enzymes Part 1: Proteolytic Enzyme Bromelain for Hydrolysis ofL-Amino Acid Methyl Esters

1977 ◽  
Vol 24 (3) ◽  
pp. 129-133 ◽  
Author(s):  
Chi-Huey Wong ◽  
Shui-Tien Chen ◽  
Kung-Tsung Wang
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Proteolytic Enzyme ◽  
Methyl Esters ◽  
Acid Methyl ◽  
Amino Acid Methyl Esters

Die Racemisierungs-Geschwindigkeit Schiffscher Basen von Aminosäure-estern / The Racemization of the Esters of N- (p-Nitrobenzylidene) -α-amino Acids

1971 ◽  
Vol 26 (8) ◽  
pp. 762-764 ◽  
Author(s):  
I. Z. Siemion ◽  
L. Wilschowitz
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Esters ◽  
Amino Acid Esters ◽  
Butyl Esters ◽  
Acid Esters

The racemization rate of N- [p-nitrobenzylidene] -α-amino acid esters was found to be even thousand-fold smaller than that of the azlactones of N-acyl-α-amino acids. t-Butyl esters of N-[p- nitrobenzylidene]-α-amino acids are much more stable to racemization as the correspondent methyl esters.

scholarly journals Determination ofd-amino acids. I. Hydrolysis of DNP-l-amino acid methyl esters with carboxypeptidase-Y

1984 ◽  
Vol 49 (6) ◽  
pp. 585-590 ◽  
Author(s):  
Peter Marfey ◽  
Martin Ottesen
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Esters ◽  
Carboxypeptidase Y ◽  
Acid Methyl ◽  
Hydrolysis Of ◽  
Amino Acid Methyl Esters
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