scholarly journals One-pot Green Synthesis for Pyrimido[4,5-d]pyrimidine Derivatives

2007 ◽  
Vol 62 (5) ◽  
pp. 732-736 ◽  
Author(s):  
Mazaahir Kidwai ◽  
Kavita Singhal ◽  
Shuchi Kukreja
Keyword(s):  
Green Synthesis ◽  
Barbituric Acid ◽  
Single Step ◽  
Environmentally Benign ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
High Yields

Abstract Water has been used efficiently as a solvent for the reaction of barbituric acid, aldehyde and urea or thiourea to yield pyrimido[4,5-d]pyrimidines. This environmentally benign procedure leads to high yields of products of greater purity in a single step using water.

scholarly journals Regioselective, one-pot, multi-component, green synthesis of substituted benzo[c]pyrazolo[2,7]naphthyridines

RSC Advances ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 5938-5950 ◽  
Author(s):  
Abida Ashraf ◽  
Zahid Shafiq ◽  
Khalid Mahmood ◽  
Muhammad Yaqub ◽  
Waqar Rauf
Keyword(s):  
Green Synthesis ◽  
Environmentally Benign ◽  
One Pot

An efficient and environmentally benign synthetic protocol has been developed for the synthesis of benzo[c]pyrazolo[2,7]naphthyridine derivatives through regioselective multi-component “on-water” reaction of isatin, malononitrile and 3-aminopyrazole.

scholarly journals NiO nanoparticles: A highly efficient catalyst for the one-pot three-component synthesis of pyrano [2, 3-d] pyrimidine derivatives in green media.

2021 ◽  
Vol 18 ◽  
Author(s):  
Ellahe Sabbaghnasab ◽  
Enayatollah Sheikhhosseini
Keyword(s):  
Barbituric Acid ◽  
Nio Nanoparticles ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Efficient Catalyst ◽  
Environmental Friendliness ◽  
Short Reaction Time ◽  
Pyrimidine Synthesis ◽  
Simple Processing ◽  
The One

: NiO nanoparticles are utilized to effectively strengthen annulated pyrano [2, 3- d] pyrimidine synthesis through primary Knoevenagel, following Micheal and ultimate heterocyclization reactions of aldehyde, malononitrile, and barbituric acid. The characteristics of NiO nanoparticles are identified using advanced techniques, such as IR, UV, EDX, XRD, SEM, and TEM. The nano-NiO particles are mostly below < 100 nm in size with uniform spherical shapes. The adopted approach is advantages thanks to its simple processing, relatively short reaction time, often good to high average yields, convenient workability, and environmental friendliness.

One-Pot Green Synthesis for Pyrimido[4,5-d]pyrimidine Derivatives

ChemInform ◽  
2007 ◽  
Vol 38 (36) ◽  
Author(s):  
Mazaahir Kidwai ◽  
Kavita Singhal ◽  
Shuchi Kukreja
Keyword(s):  
Green Synthesis ◽  
Pyrimidine Derivatives ◽  
One Pot

Fast and Efficient Green Procedure for the Synthesis of Benzo[5,6]chromene Derivatives and Their Sulfur Analogues in Water by Organocatalyst Potassium Phthalimide-N-oxyl

Synthesis ◽  
2020 ◽  
Vol 52 (11) ◽  
pp. 1707-1718
Author(s):  
Nasser Etivand ◽  
Jabbar Khalafy ◽  
Mohammad G. Dekamin
Keyword(s):  
Aqueous Media ◽  
Thiobarbituric Acid ◽  
Environmentally Benign ◽  
The Novel ◽  
One Pot ◽  
Synthetic Strategy ◽  
Three Component Reaction ◽  
High Yields ◽  
Green Procedure ◽  
Arylglyoxal Monohydrates

A simple, clean, straightforward, and environmentally benign one-pot, three-component reaction of various arylglyoxal monohydrates, β-naphthol, and barbituric acid [pyrimidine-2,4,6(1H,3H,5H)-trione] or thiobarbituric acid in the presence of catalytic amounts potassium phthalimide-N-oxyl (PPINO), as a mild and efficient organocatalyst in aqueous media under reflux conditions is reported. This transformation produced the novel diverse-substituted 12-benzoyl-8,12-dihydro-9H-benzo[5,6]chromeno[2,3-d]pyrimidine-9,11(10H)-diones and their sulfur analogues in 82–93% yield via filtration and without utilization of any chromatography. The high yields of products, very simple operation, easy workup, availability of starting materials, green process, and high atom-economy are the main benefits of this synthetic strategy.

A One-Pot, Three-Component, Solvent-Free Synthesis of Novel 6H-Chromeno[3’,4’:5,6]Pyrido[2,3-d]Pyrimidine-Triones under Microwave Irradiation

2018 ◽  
Vol 42 (12) ◽  
pp. 604-607
Author(s):  
Loghman Firoozpour ◽  
Hoda Yahyavi ◽  
Ramona Ejtemaei ◽  
Setareh Moghimi ◽  
Alireza Foroumadi
Keyword(s):  
Microwave Irradiation ◽  
Efficient Method ◽  
Barbituric Acid ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
Solvent Free Synthesis

A green and efficient method for preparing novel heterocyclic systems is established through the reaction of differently substituted benzaldehydes, barbituric acid and 4-amino-2H-chromene-2-one under solvent-free conditions. This method affords 6H-chromeno[3’,4’:5,6] pyrido[2,3-d]pyrimidine-trione derivatives in high yields and short reaction times.

CeCl3·7H2O as mild and efficient catalyst for the one-pot multicomponent synthesis of 8-aryl-7,8-dihydro[1,3]dioxolo[4,5-g]chromen-6-ones

2011 ◽  
Vol 76 (4) ◽  
pp. 235-241 ◽  
Author(s):  
Li-Qiang Wu ◽  
Wei-Lin Li ◽  
Fu-Lin Yan
Keyword(s):  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Efficient Catalyst ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
The One ◽  
High Yields ◽  
Work Up

A series of new 8-aryl-7,8-dihydro[1,3]dioxolo[4,5-g]chromen-6-ones were synthesized via a three-component reaction of 3,4-methylenedioxyphenol, aromatic aldehydes and Meldrum’s acid in the presence of CeCl3·7H2O under solvent-free conditions. The method provided several advantages such as easy work-up, high yields and environmentally benign procedure.

A novel, facile, rapid, solvent free protocol for the one pot green synthesis of chromeno[2,3-d]pyrimidines using reusable nano ZnAl2O4– a NOSE approach and photophysical studies

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6578-6587 ◽  
Author(s):  
Balijapalli Umamahesh ◽  
Triveni Rajashekhar Mandlimath ◽  
Kulathu I. Sathiyanarayanan
Keyword(s):  
Green Synthesis ◽  
Solvent Free ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Photophysical Studies ◽  
The One

The preparation of an eco-friendly, highly stable, reusable nano ZnAl2O4was used as an excellent catalyst for the pseudo four component synthesis of a library of fluorescent chromeno[2,3-d]pyrimidine derivatives.

One Pot Three Component Synthesis of 9-arylpolyhydroacridine Derivatives in an Ionic Liquid Medium

2005 ◽  
Vol 2005 (9) ◽  
pp. 600-602 ◽  
Author(s):  
Yu-Ling Li ◽  
Mei-Mei Zhang ◽  
Xiang-Shan Wang ◽  
Da-Qing Shi ◽  
Shu-Jiang Tu ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Ammonium Acetate ◽  
Aromatic Aldehydes ◽  
Environmentally Benign ◽  
Reaction Conditions ◽  
One Pot ◽  
High Yields ◽  
Work Up ◽  
Ionic Liquid Medium

In this paper the preparation of 3,3,6,6-tetramethyl-9-aryl-1,2,3,4,5,6,7,8,9,10- decahydroacridin-1,8-dione derivatives from aromatic aldehydes, 5,5-dimethyl-1,3- cyclohexanedione and ammonium acetate in ionic liquids [bmim+][BF4-] is described. This new method has the advantages of easier work-up, milder reaction conditions, high yields and an environmentally benign procedure compared with other methods.

Aqua-mediated one-pot synthesis and aromatization of pyrimido-fused 1,4-dihydropyridine derivatives using ammonium salts

2007 ◽  
Vol 85 (5) ◽  
pp. 400-405 ◽  
Author(s):  
Mazaahir Kidwai ◽  
Kavita Singhal
Keyword(s):  
Ammonium Nitrate ◽  
Single Step ◽  
Ammonium Salts ◽  
Environmentally Benign ◽  
High Yield ◽  
Pyridine Derivatives ◽  
One Pot ◽  
One Pot Synthesis ◽  
Synthetic Procedure ◽  
Dihydropyridine Derivatives

Dipyrimidine-fused pyridine derivatives were synthesized using 1,3-diketone, aldehyde, different ammonium salts, and water, as the solvent. Aromatization was observed when ammonium nitrate was used as the source of nitrogen, and thus, dipyrimidine-fused pyridine derivatives were synthesized in one-pot synthetic procedure. This environmentally benign procedure leads to high yield of products (80%–90%) in a single step, with greater purity using water as the solvent.Key words: water, aromatization, dipyrimidopyridine, ammonium salts.

scholarly journals Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium (III) chloride hydrate as a versatile homogeneous catalyst

2012 ◽  
Vol 77 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Khalil Tabatabaeian ◽  
Hannaneh Heidari ◽  
Alireza Khorshidi ◽  
Manouchehr Mamaghani ◽  
Nosrat Mahmoodi
Keyword(s):  
Michael Reaction ◽  
Aqueous Media ◽  
Environmentally Benign ◽  
Homogeneous Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
The One ◽  
High Yields ◽  
Chloride Hydrate ◽  
Short Times

The one-pot domino Knoevenagel-type condensation/Michael reaction of aromatic, heteroaromatic and aliphatic aldehydes with 4-hydroxycoumarin in aqueous media in the presence of ruthenium salt as homogeneous catalyst was investigated. It was found that 5 mol% of RuCl3.nH2O catalyzes biscoumarin synthesis in high yields (70-95%) under optimised, mild, green and environmentally benign reaction conditions in short times (25-35min).

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