scholarly journals Simple and Efficient Three Component One-Pot Synthesis of Pyrazolo[1,5,a]Pyrimidines

2014 ◽  
Vol 41 ◽  
pp. 73-81
Author(s):  
Anil R. Morabia ◽  
Yogesh T. Naliapara
Keyword(s):  
Fourier Transform ◽  
Boric Acid ◽  
Elemental Analysis ◽  
One Pot ◽  
Aryl Aldehydes ◽  
H Nmr ◽  
Reaction Condition ◽  
One Pot Synthesis ◽  
C Nmr ◽  
Operational Simplicity

A series of novel 5-(2-bromophenyl)-N-cyclohexyl-2-(methylthio)-6-nitro-7-phenyl-4,7-dihydropyrazolo [1,5-a] pyrimidine-3-carboxamides were synthesized by a one-pot reaction of 5-amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide, 1-(2-bromophenyl)-2-nitroethanone and aryl aldehydes in the presence of boric acid in water at refluxing temperature. Structures of compounds were demonstrated by Fourier transform infrared, 1H NMR, 13C NMR and elemental analysis. The advantages of this method are mild reaction condition, good yields, and operational simplicity.

scholarly journals An Efficient One Pot Synthesis of some New 1,4-Dihydropyridine Derivatives Using Multicomponent Reaction

2015 ◽  
Vol 57 ◽  
pp. 45-50
Author(s):  
Devang R. Prajapati ◽  
Hardik K. Senjani ◽  
Yogesh T. Naliapara
Keyword(s):  
Nmr Spectroscopy ◽  
Multicomponent Reaction ◽  
Elemental Analysis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Target Molecules ◽  
Dihydropyridine Derivatives ◽  
C Nmr

Synthesize target molecules, multicomponent reaction of 4-(4-aminophenyl) morpholin-3-one with various pyrazole aldehydes and ethylacetoacetate or methylacetoacetate afforded various 1,4-dihydropyridines derivatives. The newly synthesized compounds were characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis.

5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part IV. One-pot Synthesis of 1H-Pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione Derivatives Using Controlled Microwave Heating

2011 ◽  
Vol 66 (8) ◽  
pp. 843-849
Author(s):  
Raafat M. Shaker ◽  
Kamal U. Sadek ◽  
Ebtisam A. Hafez ◽  
Mohamed Abd Elrady
Keyword(s):  
Microwave Heating ◽  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
C Nmr

An efficient and direct procedure for the synthesis of pyrrolo[2,3-d]pyrimidine-2,4-dione derivatives using controlled microwave heating has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.

One-Pot Synthesis of Functionalised 4-Spiro-1,4-Dihydropyridines Via [1+2+1+2]-Cyclisation

2017 ◽  
Vol 41 (9) ◽  
pp. 513-516 ◽  
Author(s):  
Pan Zhou ◽  
Biao Hu ◽  
Lingling Lu ◽  
Rong Huang ◽  
Fuchao Yu
Keyword(s):  
Acetic Acid ◽  
Ammonium Acetate ◽  
Water Solution ◽  
Reaction Conditions ◽  
One Pot ◽  
Efficient Approach ◽  
H Nmr ◽  
Three Component Reaction ◽  
C Nmr ◽  
Operational Simplicity

A simple and efficient approach for the synthesis of 4-spiro-1,4-DHP derivatives has been developed, involving one-pot three-component reaction of isatins, N,N-dimethylenaminones with ammonium acetate in EtOH–water solution promoted by acetic acid. Compared with the previous [1+2+3]-cyclisation method, this [1+2+1+2]-cyclisation procedure has advantages as it is more environmentally friendly, has easier operational simplicity, and requires milder reaction conditions. Moreover, these novel compounds have been obtained in moderate to good yields and their structures have been confirmed by 1H NMR, 13C NMR and IR and HRMS spectroscopy.

scholarly journals 5-Aminouracil as a Building Block in Heterocyclic Synthesis: Part III. One-pot Synthesis of Novel Pyrimido[5,4-b]quinoline-2,4,9-triones and Pyrimido[5,4-c]isoquinolines

2010 ◽  
Vol 65 (12) ◽  
pp. 1485-1490 ◽  
Author(s):  
Raafat M. Shaker ◽  
Kamal U. Sadek ◽  
Ebtisam A. Hafez ◽  
Mohamed Abd Elrady
Keyword(s):  
Building Block ◽  
Heterocyclic Synthesis ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Elemental Analyses ◽  
Isoquinoline Derivatives ◽  
C Nmr

An efficient and direct procedure for the synthesis of pyrimido[5,4-b]quinoline-2,4,9-trione and pyrimido[5,4-c]isoquinoline derivatives has been described. The products were characterized by elemental analyses, IR, 1H NMR, 13C NMR and MS spectra.

scholarly journals Synthesis of Tert-Octylsalicylaldoxime and Its Application in Extraction of Cu(II)

2021 ◽  
Vol 9 ◽  
Author(s):  
Liqing Li ◽  
Luo Feng ◽  
Chunfa Liao ◽  
Fangxu Li ◽  
Liqin Yang
Keyword(s):  
Elemental Analysis ◽  
Extraction Ability ◽  
One Pot ◽  
H Nmr ◽  
Alkyl Groups ◽  
Ft Ir ◽  
Copper Nickel Alloy ◽  
The One ◽  
Yield And Purity ◽  
C Nmr

The alkyl salicylaldoxime has attracted more and more attention recently due to the complex branched alkyl groups. In this study, a novel alkyl salicylaldoxime, tert-octylsalicylaldoxime, was successfully synthesized by the one-pot method. The yield and purity by the elemental analysis were 96.17 and 94.13%, respectively. The structure was confirmed by elemental analysis, FT-IR, 1H NMR (Nuclear Magnetic Resonance), 13C NMR spectroscopy, and MS. Results showed that tert-octylsalicylaldoxime with a new structure exhibited excellent extraction ability and selectivity for Cu(II) and can be successfully used to recover Cu from copper-nickel alloy electroplating wastewater. Thus, this product has the potential to be used as a powerful copper extractant in the future.

One-Pot Synthesis of Lanthanide and Yttrium Cryptates Containing Pyridine Units

1997 ◽  
Vol 52 (10) ◽  
pp. 1273-1277 ◽  
Author(s):  
Fernando Avecilla ◽  
Rufina Bastida ◽  
Andrés de Blas ◽  
Eugenia Carrera ◽  
David E. Fenton ◽  
...  
Keyword(s):  
Schiff Base ◽  
Nmr Spectroscopy ◽  
Elemental Analysis ◽  
Molar Conductivity ◽  
One Pot ◽  
H Nmr ◽  
One Pot Synthesis ◽  
Step Procedure ◽  
One Step ◽  
High Yields

Complexes of yttrium (III) and lanthanide(III) ions with an axial macrobicycle derived from the 2+3 Schiff-base condensation of tris(2-aminoethyl)amine with 2,6-diformylpyridine have been prepared in high yields using a one-step procedure. The complexes, with formula [M2L](NO3)6 · xH2O · ySolv, (M = Y, La - Lu, except Pm) and [M 2L](ClO4)6 · xH2O · ySolv, (M = La - Er, except Pm ), have been characterised by elemental analysis, molar conductivity, mass, IR and 1H NMR spectroscopy.

Synthesis of Some 2-Aminonitroethanes via Silica Gel-Catalyzed Nitro-Mannich Reaction

2006 ◽  
Vol 61 (9) ◽  
pp. 1162-1165 ◽  
Author(s):  
Ali S. Mahasneh
Keyword(s):  
Silica Gel ◽  
Elemental Analysis ◽  
Mannich Reaction ◽  
Nmr Spectra ◽  
One Pot ◽  
H Nmr ◽  
High Yields ◽  
C Nmr

Abstract A direct one pot, three-component nitro-Mannich reaction of a nonenolizable aldehyde, aniline or one of its ring-substituted derivatives and nitromethane was carried out on silica gel surface. The products of the reaction, 2-aminonitroethane, were obtained in high yields. IR, 1H NMR, 13C NMR spectra and elemental analysis confirmed the structures of the products.

Synthesis and antimicrobial activity evaluation of new norfloxacine-azole hybrids

2018 ◽  
Vol 24 (6) ◽  
pp. 317-325 ◽  
Author(s):  
Serpil Demirci ◽  
Neslihan Demirbaş ◽  
Meltem Menteşe ◽  
SerapBaşoğlu Özdemir ◽  
Şengül A. Karaoğlu
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Elemental Analysis ◽  
Antimicrobial Activities ◽  
One Pot ◽  
H Nmr ◽  
Microwave Assisted ◽  
Three Component Reaction ◽  
Amino Derivatives ◽  
C Nmr

Abstract Norfloxacin-azole hybrids 3 and 6a,b were synthesized starting from norfloxacin. The treatment of these compounds with amines as a one-pot three-component reaction produced the corresponding amino derivatives 4a,b, 7a–g and 8a,b in good yields. The conventional and microwave-assisted methods were used with the latter method being more efficient. The structures of the synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13C NMR and MS. All compounds were screened for their antimicrobial activities. Most of them exhibit excellent antibacterial activity but are not active against selected fungi.

Facile Approach to Geminal Heterodihalogenation. One-Pot Synthesis of α-Bromo-α-Chloro Ketones

Synlett ◽  
2020 ◽  
Vol 31 (14) ◽  
pp. 1430-1434
Author(s):  
Ming Bian ◽  
Jin-feng Zhou ◽  
Dong-min Tang
Keyword(s):  
Drug Discovery ◽  
Dimethyl Sulfoxide ◽  
Functional Groups ◽  
Methyl Ketones ◽  
One Pot ◽  
One Pot Synthesis ◽  
Operational Simplicity

An efficient and practical protocol for the geminal heterodihalogenation of methyl ketones by using readily available dimethyl sulfoxide and a combination of HCl and HBr is reported. Control experiments suggested that the acidity of the solution, as well as the oxidizing ability and nucleophilicity of the dimethyl sulfoxide might work cooperatively in ensuring the success of the tandem substitution. Its operational simplicity, easy accessibility, and mild oxidative conditions suggest that the present strategy might be useful for the assembly of bromochloromethyl functional groups in drug discovery.

Solvent-free, one-pot synthesis of 2,4,6-triarylpyridines using trichloroisocyanuric acid or N-bromosuccinimide as a novel and neutral catalyst

2011 ◽  
Vol 76 (11) ◽  
pp. 1307-1315 ◽  
Author(s):  
Behrooz Maleki ◽  
Hafezeh Salehabadi ◽  
Zeinalabedin Sepehr ◽  
Mina Kermanian
Keyword(s):  
Ammonium Acetate ◽  
Solvent Free ◽  
One Pot ◽  
Aryl Aldehydes ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Trichloroisocyanuric Acid

A simple and benign protocol has been explored for the preparation of 2,4,6-triarylpyridines by a one-pot reaction between aryl aldehydes, enolizable ketones and ammonium acetate in the presence of N-bromosuccinimide or trichloroisocyanuric acid as green and neutral catalysts. The reactions proceed smoothly at 130 °C under solvent-free conditions to provide 2,4,6-triarylpyridines in good yields.

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