Desialylation of Low Density Lipoprotein -Metabolic Function versus Oxidative Damage ?

1996 ◽  
Vol 51 (5-6) ◽  
pp. 395-400 ◽  
Author(s):  
E. H. Schlüssel ◽  
E. F. Elstner
Keyword(s):  
Oxidative Damage ◽  
Function Versus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Vascular Diseases ◽  
Low Density Lipoproteins ◽  
Carbohydrate Content ◽  
Low Density ◽  
Metabolic Function ◽  
Lipoprotein Particles

Abstract Low density lipoproteins are generally considered to play a major role in the development of atherosclerotic vascular diseases. There is growing interest in LDL subspecies, especially in their density, carbohydrate content and oxidizability, which is supposed to enhance athero-genicity. We investigated the influence of desialylation on the resistance of the lipoprotein particles towards Cu(II) prooxidative activity.

Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall

2019 ◽  
Vol 26 (9) ◽  
pp. 1701-1710 ◽  
Author(s):  
Katariina Öörni ◽  
Satu Lehti ◽  
Peter Sjövall ◽  
Petri T. Kovanen
Keyword(s):  
Arterial Wall ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density Lipoproteins ◽  
Low Density ◽  
Lipoprotein Particles ◽  
Atherosclerotic Lesions ◽  
Remnant Lipoproteins

Apolipoprotein B –containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial wall, where they accumulate and induce the formation of atherosclerotic lesions. The processes that lead to accumulation of lipoprotein-derived lipids in the arterial wall have been largely studied with a focus on the low-density lipoprotein particles. However, recent observational and genetic studies have discovered that the triglyceriderich lipoproteins and their remnants are linked with cardiovascular disease risk. In this review, we describe the potential mechanisms by which the triglyceride-rich remnant lipoproteins can contribute to the development of atherosclerotic lesions, and highlight the differences in the atherogenicity between low-density lipoproteins and the remnant lipoproteins.

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