Antiviral Activity of Some Hydroxycoumarin Derivatives

Abstract Esculetin (6,7-dihydroxycoumarin) and its diacetate exhibited a marked inhibitory effect on Newcastle disease virus replication in cell cultures at concentrations of 36 jam and 62 jam, respectively. These compounds were selected from ten hydroxycoumarin derivatives through an in vitro antiviral screen involving viruses of the picorna-, orthomyxo-, paramyxo-, and herpes virus families.

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In vitro characterization of the antiviral activity of fucoidan from Cladosiphon okamuranus against Newcastle Disease Virus

Virology Journal ◽

10.1186/1743-422x-9-307 ◽

2012 ◽

Vol 9 (1) ◽

pp. 307 ◽

Cited By ~ 56

Author(s):

Regina Elizondo-Gonzalez ◽

L Elizabeth Cruz-Suarez ◽

Denis Ricque-Marie ◽

Edgar Mendoza-Gamboa ◽

Cristina Rodriguez-Padilla ◽

...

Keyword(s):

Antiviral Activity ◽

Newcastle Disease Virus ◽

Disease Virus ◽

Newcastle Disease ◽

In Vitro Characterization ◽

Cladosiphon Okamuranus

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In vitro antiviral potential of Ocimum basilicum and Olea europaea leaves extract against Newcastle Disease Virus of poultry

The Iraqi Journal of Veterinary Medicine ◽

10.30539/iraqijvm.v39i1.204 ◽

2015 ◽

Vol 39 (1) ◽

pp. 94-99

Author(s):

Sarah A. H. Al-Amri1

Keyword(s):

Antiviral Activity ◽

Newcastle Disease Virus ◽

Disease Virus ◽

Newcastle Disease ◽

Olea Europaea ◽

Chicken Embryo Fibroblast ◽

Ocimum Basilicum ◽

Cytopathic Effects ◽

Olea Europaéa

This study was carried out to investigate the effect of using alcoholic Ocimum basilicum and Olea europaea leaves extract, to study the antiviral activity against the Newcastle disease virus of poultry chicken embryo fibroblast monolayer culture. The extract was also decided for the chicken fibroblast culture and the concentrations (500, 250, 125, 100 and 50 µg /ml) of an alcoholic extract of Ocimum basilicum and Olea europaea leaves in maintenance media appeared to be nontoxic. Where the cytopathic effects of the Newcastle disease virus on chicken embryo fibroblast monolayer culture are well established so these concentrations were used to detect the antiviral activity of Ocimum basilicum and Olea europaea in addition to in vitro, pre and post -inoculative treatment of fibroblast cells with plant extracts to get an idea of viral reduction titer in cell tissue culture. Absence of cytopathic effects in monolayer cell culture and virus titer reduction were used as an indicative of antiviral activity of extract of Ocimum basilicum and Olea europaea leaves. In vitro, pre and post -inoculative treatment of fibroblast cells with plant extracts showed that leaves of Ocimum basilicum, and Olea europaea had antiviral activities of Newcastle disease virus at 500 and 250 µg/ml. In conclusion the viral reduction titer was found range between 10-6 to 10-1 with 500 µg /ml of Olea europaea and Ocimum basilicum extract as compared to 10-7 with virus control.

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In vitro and in vivo broad antiviral activity of peptides homologous to fusion glycoproteins of Newcastle disease virus and Marek's disease virus

Journal of Virological Methods ◽

10.1016/j.jviromet.2013.12.022 ◽

2014 ◽

Vol 199 ◽

pp. 11-16 ◽

Cited By ~ 2

Author(s):

Xiao-Jing Chi ◽

Xiao-Jun Wang ◽

Cheng-Yu Wang ◽

Xiao-Jing Cui ◽

Xiao-Jia Wang

Keyword(s):

Antiviral Activity ◽

Newcastle Disease Virus ◽

Disease Virus ◽

Newcastle Disease ◽

Marek's Disease Virus ◽

Marek's Disease ◽

Marek’S Disease Virus ◽

Marek’S Disease

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Synthesis and chemical characterization of several perfluorinated sialic acid glycals and evaluation of their in vitro antiviral activity against Newcastle disease virus

MedChemComm ◽

10.1039/c7md00072c ◽

2017 ◽

Vol 8 (7) ◽

pp. 1505-1513 ◽

Cited By ~ 6

Author(s):

P. Rota ◽

N. Papini ◽

P. La Rocca ◽

M. Montefiori ◽

F. Cirillo ◽

...

Keyword(s):

Sialic Acid ◽

Antiviral Activity ◽

Newcastle Disease Virus ◽

Disease Virus ◽

Newcastle Disease ◽

Chemical Characterization ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Synthesis and biological evaluation of some C-5 modified sialic acid glycals, epimerized or not at the C-4 position, as HN inhibitors of Newcastle Disease Virus (NDV).

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