Structural Characteristics of a Bioactive Polysaccharide from Sorghum arundinaceum

2003 ◽  
Vol 58 (5-6) ◽  
pp. 342-346 ◽  
Author(s):  
Bernadete P. da Silva ◽  
Graziela M. Silva ◽  
José P. Parente
Keyword(s):  
Molecular Weight ◽  
Capillary Permeability ◽  
Structural Characteristics ◽  
Apparent Molecular Weight ◽  
Spectroscopic Studies ◽  
Type Structure ◽  
Inflammatory Activity ◽  
Branching Points ◽  
Anti Inflammatory ◽  
Permeability Assay

AbstractA polysaccharide, an α-ᴅ -glucan with an apparent molecular weight of 6.85×104, called PSa glucan, was isolated from fresh seeds of Sorghum arundinaceum by fractionation on Sephacryl S-300 HR and Sephadex G-25. Chemical and spectroscopic studies indicated that it has a highly branched glucan type structure composed of α-(154) linked d-glucopyranose residues with (1→3), (1→6) branching points, and a significant amount of α-(1→6) branching to α-(1→3) linked ᴅ -glucopyranose residues. The anti-inflammatory activity of the polysaccharide was performed using the capillary permeability assay.

A New Bioactive Steroidal Saponin from Agave attenuata

2002 ◽  
Vol 57 (5-6) ◽  
pp. 423-428 ◽  
Author(s):  
Bernadete P. da Silva ◽  
Allyne C. de Sousa ◽  
Graziela M. Silva ◽  
Tatiana P. Mendes ◽  
José P. Parente
Keyword(s):  
Nmr Spectra ◽  
Capillary Permeability ◽  
Structural Identification ◽  
2D Nmr ◽  
Inflammatory Activity ◽  
Steroidal Saponin ◽  
Spectroscopic Techniques ◽  
Anti Inflammatory ◽  
Permeability Assay ◽  
C Nmr

A new steroidal saponin was isolated from the leaves of Agave attenuata Salm-Dyck. Its structure was established as (3β,5β,22α,25S)-26-(β-ᴅ-glucopyranosyloxy)-22-methoxyfurostan- 3-yl O-β-ᴅ-glucopyranosyl-(1→2)-β-ᴅ-glucopyranosyl-(1→2)-O-[β-ᴅ-glucopyranosyl- (1→3)]-β-ᴅ-glucopyranosyl-(1→4)-β-ᴅ-galactopyranoside. The structural identification was performed using detailed analyses of 1H and 13C NMR spectra including 2D NMR spectroscopic techniques (COSY, HETCOR and COLOC) and chemical conversions. The haemolytic potential of the steroidal saponin was evaluated and the anti-inflammatory activity was performed using the capillary permeability assay.

scholarly journals Thiophene-Based Compounds with Potential Anti-Inflammatory Activity

2021 ◽  
Vol 14 (7) ◽  
pp. 692
Author(s):  
Ryldene Marques Duarte da Cruz ◽  
Francisco Jaime Bezerra Mendonça-Junior ◽  
Natália Barbosa de Mélo ◽  
Luciana Scotti ◽  
Rodrigo Santos Aquino de Araújo ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Structural Characteristics ◽  
Tiaprofenic Acid ◽  
Inflammatory Activity ◽  
Drug Candidates ◽  
Biological Target ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Privileged Structures

Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are public health problems and represent major therapeutic challenges. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most prescribed clinical treatments, despite their severe side effects and their exclusive action in improving symptoms, without effectively promoting the cure. However, recent advances in the fields of pharmacology, medicinal chemistry, and chemoinformatics have provided valuable information and opportunities for development of new anti-inflammatory drug candidates. For drug design and discovery, thiophene derivatives are privileged structures. Thiophene-based compounds, like the commercial drugs Tinoridine and Tiaprofenic acid, are known for their anti-inflammatory properties. The present review provides an update on the role of thiophene-based derivatives in inflammation. Studies on mechanisms of action, interactions with receptors (especially against cyclooxygenase (COX) and lipoxygenase (LOX)), and structure-activity relationships are also presented and discussed. The results demonstrate the importance of thiophene-based compounds as privileged structures for the design and discovery of novel anti-inflammatory agents. The studies reveal important structural characteristics. The presence of carboxylic acids, esters, amines, and amides, as well as methyl and methoxy groups, has been frequently described, and highlights the importance of these groups for anti-inflammatory activity and biological target recognition, especially for inhibition of COX and LOX enzymes.

Anti-Inflammatory Activity in the Low Molecular Weight Fraction of Commercial Human Serum Albumin (LMWF5A)

2015 ◽  
Vol 37 (1) ◽  
pp. 55-67 ◽  
Author(s):  
Gregory W. Thomas ◽  
Leonard T. Rael ◽  
Charles W. Mains ◽  
Denetta Slone ◽  
Matthew M. Carrick ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Weight Fraction ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Anti Inflammatory

scholarly journals A selective novel low-molecular-weight inhibitor of Iκ B kinase-β (IKK-β ) prevents pulmonary inflammation and shows broad anti-inflammatory activity

2005 ◽  
Vol 145 (2) ◽  
pp. 178-192 ◽  
Author(s):  
Karl Ziegelbauer ◽  
Florian Gantner ◽  
Nicholas W Lukacs ◽  
Aaron Berlin ◽  
Kinji Fuchikami ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Pulmonary Inflammation ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Anti Inflammatory

Effect of chitosan molecular weight on anti-inflammatory activity in the RAW 264.7 macrophage model

2019 ◽  
Vol 131 ◽  
pp. 167-175 ◽  
Author(s):  
Shun-Hsien Chang ◽  
Yi-Yung Lin ◽  
Guan-James Wu ◽  
Chung-Hsiung Huang ◽  
Guo Jane Tsai
Keyword(s):  
Molecular Weight ◽  
Inflammatory Activity ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophage ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Anahita Shahraz ◽  
Jens Kopatz ◽  
Rene Mathy ◽  
Joachim Kappler ◽  
Dominic Winter ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Polysialic Acid ◽  
Inflammatory Activity ◽  
Low Molecular Weight ◽  
Human Macrophages ◽  
Anti Inflammatory

scholarly journals Interaction of 5′-Guanosine Monophosphate with Organotin(IV) Moieties: Synthesis, Structural Characterization, and Anti-Inflammatory Activity

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Mala Nath ◽  
Hitendra Singh ◽  
George Eng ◽  
Xueqing Song
Keyword(s):  
Structural Characterization ◽  
Spectroscopic Studies ◽  
Guanosine Monophosphate ◽  
Inflammatory Activity ◽  
Albino Rats ◽  
Trigonal Bipyramidal ◽  
Ft Ir ◽  
Anti Inflammatory ◽  
Derivatives Of ◽  
Distorted Trigonal Bipyramidal

Reaction(s) of 5′-guanosine monophosphate (5′GMP) with di- and triorganotin(IV) chloride(s) led to formation of organotin(IV) derivatives of general formulae, [R2Sn(5′-GMP)·H2O]n and [(R′3Sn)2(5′-GMP)·H2O]n, where R = Me, n-Bu, and Ph; R′ = Me, i-Pr, n-Bu, and Ph; (5′-GMP)2− = 5′-guanosine monophosphate. An attempt has been made to prove the structures of the resulting derivatives on the basis of FT-IR, multinuclear 1H, 13C, and 119Sn NMR and 119Sn Mössbauer spectroscopic studies. These investigations suggest that both di- and triorganotin(IV)-5′-guanosine monophosphates are polymeric in which (5′-GMP)2− is bonded through phosphate group resulting in a distorted trigonal bipyramidal geometry around tin. The ribose conformation in all of the derivatives is C3′-endo, except diphenyltin(IV) and tri-i-propyltin(IV) derivatives where it is C2′-endo. All of the studied derivatives exhibited mild-to-moderate anti-inflammatory activity (~15.64–20.63% inhibition) at 40 mg kg−1 dose and LD50 values > 400 mg kg−1 in albino rats.

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