Light-Stimulated Generation of Free Radicals by Quinones-Chelators
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AbstractThe role of metal ions in the mechanism of light-stimulated redox activity of potential anticancer agent 2-phenyl-4-(butylamino)naphtha[2,3-h]quinoline-7,12-dione (Qc) has been studied by CIDNP (chemically induced dynamic nuclear polarization) and EPR methods. The photo-induced oxidation of NADH and its synthetic analog – substituted dihydropyridine (DHP) – by quinone Qc was used as a model. The Qc capability of producing chelating complexes with divalent metal ions of Fe, Zn and Ca was studied quantitatively by optical absorption spectroscopy. A significant decrease of electrochemical reduction potential of Qc (Δ
2001 ◽
Vol 46
(2)
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pp. 346-354
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1997 ◽
Vol 28
(2)
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pp. 268-284
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1997 ◽
Vol 61
(10)
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pp. 1688-1692
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1999 ◽
Vol 103
(18)
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pp. 3430-3437
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2018 ◽
Vol 452
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pp. 022057