Light-Stimulated Generation of Free Radicals by Quinones-Chelators

2017 ◽  
Vol 231 (2) ◽  
Author(s):  
Irina D. Markova ◽  
Nikolay E. Polyakov ◽  
Olga Yu. Selyutina ◽  
Lidia G. Fedenok ◽  
Kirill Yu. Fedotov ◽  
...  

AbstractThe role of metal ions in the mechanism of light-stimulated redox activity of potential anticancer agent 2-phenyl-4-(butylamino)naphtha[2,3-h]quinoline-7,12-dione (Qc) has been studied by CIDNP (chemically induced dynamic nuclear polarization) and EPR methods. The photo-induced oxidation of NADH and its synthetic analog – substituted dihydropyridine (DHP) – by quinone Qc was used as a model. The Qc capability of producing chelating complexes with divalent metal ions of Fe, Zn and Ca was studied quantitatively by optical absorption spectroscopy. A significant decrease of electrochemical reduction potential of Qc (Δ

1989 ◽  
Vol 90 (1) ◽  
pp. 359-364 ◽  
Author(s):  
H. Frits Bienfait ◽  
Henk J. Lubberding ◽  
Peter Heutink ◽  
L. Lindner ◽  
Jacques Visser ◽  
...  

FEBS Open Bio ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. 345-352 ◽  
Author(s):  
Elias Tannous ◽  
Koji Yokoyama ◽  
Dong-Ju You ◽  
Yuichi Koga ◽  
Shigenori Kanaya

Biochemistry ◽  
1991 ◽  
Vol 30 (39) ◽  
pp. 9464-9469 ◽  
Author(s):  
SueAnn C. Dahm ◽  
Olke C. Uhlenbeck

Author(s):  
Fuchun Zhao ◽  
Jie Guan ◽  
Wanna Bai ◽  
Tingting Gu ◽  
Huan Liu ◽  
...  

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