scholarly journals 3-Phenylcoumarins as a Privileged Scaffold in Medicinal Chemistry: The Landmarks of the Past Decade

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6755
Author(s):  
Maria J. Matos ◽  
Eugenio Uriarte ◽  
Lourdes Santana
Keyword(s):  
Medicinal Chemistry ◽  
Review Paper ◽  
Relevant Literature ◽  
Natural Origin ◽  
Drug Candidates ◽  
Heterocyclic Molecules ◽  
The Past ◽  
New Drug ◽  
Privileged Scaffold

3-Phenylcoumarins are a family of heterocyclic molecules that are widely used in both organic and medicinal chemistry. In this overview, research on this scaffold, since 2010, is included and discussed, focusing on aspects related to its natural origin, synthetic procedures and pharmacological applications. This review paper is based on the most relevant literature related to the role of 3-phenylcoumarins in the design of new drug candidates. The references presented in this review have been collected from multiple electronic databases, including SciFinder, Pubmed and Mendeley.

scholarly journals Fluid Flow and Mass Transport in Brain Tissue

Fluids ◽  
2019 ◽  
Vol 4 (4) ◽  
pp. 196 ◽  
Author(s):  
Lori A. Ray ◽  
Jeffrey J. Heys
Keyword(s):  
Potential Role ◽  
Relevant Literature ◽  
Brain Dysfunction ◽  
Transport Processes ◽  
The Past ◽  
Advective Flows ◽  
The Brain ◽  
Flow And Mass Transport ◽  
Removal System

Despite its small size, the brain consumes 25% of the body’s energy, generating its own weight in potentially toxic proteins and biological debris each year. The brain is also the only organ lacking lymph vessels to assist in removal of interstitial waste. Over the past 50 years, a picture has been developing of the brain’s unique waste removal system. Experimental observations show cerebrospinal fluid, which surrounds the brain, enters the brain along discrete pathways, crosses a barrier into the spaces between brain cells, and flushes the tissue, carrying wastes to routes exiting the brain. Dysfunction of this cerebral waste clearance system has been demonstrated in Alzheimer’s disease, traumatic brain injury, diabetes, and stroke. The activity of the system is observed to increase during sleep. In addition to waste clearance, this circuit of flow may also deliver nutrients and neurotransmitters. Here, we review the relevant literature with a focus on transport processes, especially the potential role of diffusion and advective flows.

Bipolar Disorders and Their Clinical Management, Part I: Epidemiology, Etiology, Genetics, and Neurobiology

2019 ◽  
Author(s):  
Vladimir Maletic ◽  
Bernadette DeMuri-Maletic
Keyword(s):  
Autistic Spectrum Disorder ◽  
Relevant Literature ◽  
Genetic Research ◽  
Bipolar Disorders ◽  
Major Depressive ◽  
Disease Evolution ◽  
The Past ◽  
Endocrine Disturbances ◽  
Brain Changes

The concept of bipolar disorders has undergone a substantial evolution over the course of the past two decades. Emerging scientific research no longer supports the notion of bipolar disorder as a discrete neurobiologic entity. Most likely, there are a number of different biotypes with similar phenotypical manifestations. Advancements in genetic research suggest that bipolar disorders have a polygenetic pattern of inheritance, sharing common genetic underpinnings with a number of other psychiatric disorders, including schizophrenia, autistic spectrum disorder, and major depressive disorder. Contemporary etiological theories are discussed in some detail, inclusive of the role of immune disturbances, oxidative stress, and changes in neuroplasticity and neurotransmission, which underpin functional and structural brain changes associated with bipolar disorders. Contemporary epidemiologic research and understanding of disease evolution are discussed from the perspective of its clinical relevance. Our review provides a succinct summary of relevant literature. This review contains 4 figures, 2 tables, and 80 references. Key Words: bipolar disorders, endocrine disturbances, epidemiology, genetics, glia, immunity, neurobiology, neuroplasticity, neurotransmitters

Bipolar Disorders and Their Clinical Management, Part I: Epidemiology, Etiology, Genetics, and Neurobiology

2019 ◽  
Author(s):  
Vladimir Maletic ◽  
Bernadette DeMuri-Maletic
Keyword(s):  
Autistic Spectrum Disorder ◽  
Relevant Literature ◽  
Genetic Research ◽  
Bipolar Disorders ◽  
Major Depressive ◽  
Disease Evolution ◽  
The Past ◽  
Endocrine Disturbances ◽  
Brain Changes

The concept of bipolar disorders has undergone a substantial evolution over the course of the past two decades. Emerging scientific research no longer supports the notion of bipolar disorder as a discrete neurobiologic entity. Most likely, there are a number of different biotypes with similar phenotypical manifestations. Advancements in genetic research suggest that bipolar disorders have a polygenetic pattern of inheritance, sharing common genetic underpinnings with a number of other psychiatric disorders, including schizophrenia, autistic spectrum disorder, and major depressive disorder. Contemporary etiological theories are discussed in some detail, inclusive of the role of immune disturbances, oxidative stress, and changes in neuroplasticity and neurotransmission, which underpin functional and structural brain changes associated with bipolar disorders. Contemporary epidemiologic research and understanding of disease evolution are discussed from the perspective of its clinical relevance. Our review provides a succinct summary of relevant literature. This review contains 4 figures, 2 tables, and 80 references. Key Words: bipolar disorders, endocrine disturbances, epidemiology, genetics, glia, immunity, neurobiology, neuroplasticity, neurotransmitters

Can GPs coordinate “whole person care”?

2015 ◽  
Vol 23 (1) ◽  
pp. 10-16
Author(s):  
Bob Hudson
Keyword(s):  
Design Methodology ◽  
Relevant Literature ◽  
Original Research ◽  
Service Users ◽  
Care Coordinator ◽  
Policy Documents ◽  
Content Type ◽  
The Past ◽  
Whole Person

Purpose – As the notion of “integrated care” has received ever greater policy traction, so the idea that a named individual should take responsibility for coordinating the various elements of care for service users has also gained ground. The purpose of this paper is to look at the proposal to hand this role to GPs, examine the policy expectations and explore some of the implementation dilemmas. Design/methodology/approach – Review of policy documents and relevant literature. Findings – That the role of “care coordinator” has rarely succeeded in the past and that there are specific difficulties in expecting GPs to take on the task. Research limitations/implications – Review of existing literature linked to emergent policy – no original research. Originality/value – This is a new application of an enduring policy concept. Currently the literature is thin.

scholarly journals Natural bio-based monomers for biomedical applications: a review

2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Mallinath S. Birajdar ◽  
Haejin Joo ◽  
Won-Gun Koh ◽  
Hansoo Park
Keyword(s):  
Biomedical Applications ◽  
New Products ◽  
Well Being ◽  
Synthetic Polymer ◽  
Polymer Materials ◽  
Natural Origin ◽  
The Past ◽  
Synthetic Materials ◽  
Suitable Potential

Abstract In recent years, synthetic and semi-synthetic polymer materials have been widely used in various applications. Especially concerning biomedical applications, their biocompatibility, biodegradability, and non-toxicity have increased the interest of researchers to discover and develop new products for the well-being of humanity. Among the synthetic and semi-synthetic materials, the use of natural bio-based monomeric materials presents a possible novel avenue for the development of new biocompatible, biodegradable, and non-toxic products. The purpose of this article is to review the information on the role of natural bio-based monomers in biomedical applications. Increased eco-friendliness, biocompatibility, biodegradability, non-toxicity, and intrinsic biological activity are some of the attributes which make itaconic, succinic, citric, hyaluronic, and glutamic acids suitable potential materials for biomedical applications. Herein, we summarize the most recent advances in the field over the past ten years and specifically highlight new and interesting discoveries in biomedical applications. Graphical abstract Natural origin acid-based bio-monomers for biomedical applications

scholarly journals Enabling technologies for the preparation of multifunctional “bullets” for nanomedicine

2018 ◽  
pp. 134-143
Author(s):  
K. Martina ◽  
L. Serpe ◽  
R. Cavalli ◽  
G. Cravotto
Keyword(s):  
Ultrasound Irradiation ◽  
Stimuli Responsive ◽  
Enabling Technology ◽  
Drug Formulations ◽  
Transdisciplinary Approach ◽  
Drug Candidates ◽  
The Past ◽  
New Drug ◽  
Enabling Technologies ◽  
Diagnostic Agents

Recent advances in nanotechnology, including modern enabling techniques that can improve synthetic preparation and drug formulations, have opened up new frontiers in nanomedicine with the development of nanoscale carriers and assemblies. The use of delivery platforms has attracted attention over the past decade as researchers shift their focus away from the development of new drug candidates, and toward new means with which to deliver therapeutic and/or diagnostic agents. This work will explore a transdisciplinary approach for the production of a number of nanomaterials, nanocomplexes and nanobubbles and their application in a variety of potential biological and theranostic protocols. Particular attention will be paid to nanobubbles, stimuli responsive nanoparticles and cyclodextrin grafted nanosystems produced under non-conventional conditions, such as microwave and ultrasound irradiation. Besides nanoparticles preparation, ultrasound can also act as an enabling technology when activating sensitive nanobubbles and nanoparticles.

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease

2011 ◽  
Vol 10 (2) ◽  
pp. 239-250 ◽  
Author(s):  
Helineide Cristina Campos ◽  
Miguel Divino da Rocha ◽  
Flavia Pereira Dias Viegas ◽  
Patricia Carolina Nicastro ◽  
Poliana Calve Fossaluzza ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurodegenerative Disorders ◽  
Parkinsons Disease ◽  
Drug Candidates ◽  
New Drug

scholarly journals Role of Artificial Intelligence in the Internet of Things (IoT) cybersecurity

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Murat Kuzlu ◽  
Corinne Fair ◽  
Ozgur Guler
Keyword(s):  
Artificial Intelligence ◽  
Internet Of Things ◽  
Review Paper ◽  
Relevant Literature ◽  
The Internet ◽  
Research Papers ◽  
Use Of The Internet ◽  
The Relationship ◽  
The Internet Of Things

AbstractIn recent years, the use of the Internet of Things (IoT) has increased exponentially, and cybersecurity concerns have increased along with it. On the cutting edge of cybersecurity is Artificial Intelligence (AI), which is used for the development of complex algorithms to protect networks and systems, including IoT systems. However, cyber-attackers have figured out how to exploit AI and have even begun to use adversarial AI in order to carry out cybersecurity attacks. This review paper compiles information from several other surveys and research papers regarding IoT, AI, and attacks with and against AI and explores the relationship between these three topics with the purpose of comprehensively presenting and summarizing relevant literature in these fields.

Bipolar Disorders and Their Clinical Management, Part I: Epidemiology, Etiology, Genetics, and Neurobiology

2019 ◽  
Author(s):  
Vladimir Maletic ◽  
Bernadette DeMuri-Maletic
Keyword(s):  
Autistic Spectrum Disorder ◽  
Relevant Literature ◽  
Genetic Research ◽  
Bipolar Disorders ◽  
Major Depressive ◽  
Disease Evolution ◽  
The Past ◽  
Endocrine Disturbances ◽  
Brain Changes

The concept of bipolar disorders has undergone a substantial evolution over the course of the past two decades. Emerging scientific research no longer supports the notion of bipolar disorder as a discrete neurobiologic entity. Most likely, there are a number of different biotypes with similar phenotypical manifestations. Advancements in genetic research suggest that bipolar disorders have a polygenetic pattern of inheritance, sharing common genetic underpinnings with a number of other psychiatric disorders, including schizophrenia, autistic spectrum disorder, and major depressive disorder. Contemporary etiological theories are discussed in some detail, inclusive of the role of immune disturbances, oxidative stress, and changes in neuroplasticity and neurotransmission, which underpin functional and structural brain changes associated with bipolar disorders. Contemporary epidemiologic research and understanding of disease evolution are discussed from the perspective of its clinical relevance. Our review provides a succinct summary of relevant literature. This review contains 4 figures, 2 tables, and 80 references. Key Words: bipolar disorders, endocrine disturbances, epidemiology, genetics, glia, immunity, neurobiology, neuroplasticity, neurotransmitters

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