Microalbuminuria associated with Type (II) Diabetes mellitus is a strong predictor of upcoming Diabetic Nephropathy. It is a major cause of Diabetic kidney disease, leading to mortality and morbidity in these patients. The cost of treatment in a Diabetic kidney disease is huge; the cost may further escalate unless prevention and intervention are initiated at an earlier stage, which would help in minimizing further com-plications. The current treatment modalities of ACE inhibitors and RAS blockades alone cannot support this disease. Ayurveda with its array of herbal and mineral medicines has been used for managing this dis-ease and its complications. Tarakeswara Rasa is one such formulation used in managing Diabetes. It is a herbo-mineral formulation containing Rasasindoora, Loha, Vanga and Abraka Bhasmas each of which are potent Rasa Rasayana’s used in treating Diabetes. The study drug was meticulously prepared and analyzed for XRD, XRF, PSA etc. An interventional study was conducted for evaluating the effect of Tarakeswara Rasa in 20 Type (II) Diabetic patients having Microalbumin from 30-300mg/g. Tarakeswara rasa with a dosage of 125mg was administered twice daily with honey and Udumbaraphala (fig’s) 3g as Anupana (ve-hicle). The patients were asked to follow a strict diet and exercise regimen for a period of 1 month. The outcome variables such as level of Microalbumin in urine, FBS, PPBS, HbA1c, Urinary sugar and albumin, Blood Pressure and Serum cholesterol were analyzed using paired ‘t’ test and symptomatic change ana-lyzed before and after treatment using Wilcoxon signed rank test. The results showed that, the study drug Tarakeswara Rasa is effective in managing Microalbuminuria associated with Type (II) Diabetes Mellitus supported by laboratory findings and also improves the overall quality of life of Diabetic patients.
The potential of N-glycosylation profiles as biomarkers for monitoring the progression of Type II diabetes mellitus towards diabetic kidney disease
