Paracellular drug absorption enhancement through tight junction modulation

2012 ◽  
Vol 10 (1) ◽  
pp. 103-114 ◽  
Author(s):  
Hendrik JR Lemmer ◽  
Josias H Hamman
Keyword(s):  
Tight Junction ◽  
Drug Absorption ◽  
Absorption Enhancement

scholarly journals Strategies to Enhance Drug Absorption via Nasal and Pulmonary Routes

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 113 ◽  
Author(s):  
Maliheh Ghadiri ◽  
Paul Young ◽  
Daniela Traini
Keyword(s):  
Nucleic Acid ◽  
Tight Junction ◽  
Drug Absorption ◽  
Therapeutic Agents ◽  
Nasal Administration ◽  
Absorption Enhancers ◽  
Non Invasive ◽  
Basic Concepts ◽  
Transmucosal Administration ◽  
Poor Absorption

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are being developed every year, making it vital to find a non-invasive route such as nasal or pulmonary for their administration. However, a major concern for some of these newly developed therapeutic agents is their poor absorption. Therefore, absorption enhancers have been investigated to address this major administration problem. This paper describes the basic concepts of transmucosal administration of drugs, and in particular the use of the pulmonary or nasal routes for administration of drugs with poor absorption. Strategies for the exploitation of absorption enhancers for the improvement of pulmonary or nasal administration are discussed, including use of surfactants, cyclodextrins, protease inhibitors, and tight junction modulators, as well as application of carriers such as liposomes and nanoparticles.

scholarly journals IMPROVEMENT OF GASTROINTESTINAL DRUG ABSORPTION BASED ON OPENING THE TIGHT JUNCTION

1995 ◽  
Vol 10 (supplement) ◽  
pp. 84-87
Author(s):  
Nobuyuki TANAKA ◽  
Mikio TOMITA ◽  
Shoji AWAZU
Keyword(s):  
Tight Junction ◽  
Drug Absorption

Intestinal drug absorption enhancement: An overview

1989 ◽  
Vol 44 (3) ◽  
pp. 407-443 ◽  
Author(s):  
Ewoud J. van Hoogdalem ◽  
Albertus G. de Boer ◽  
Douwe D. Breimer
Keyword(s):  
Drug Absorption ◽  
Absorption Enhancement ◽  
Intestinal Drug Absorption

Direct Inhibition of the First PDZ Domain of ZO-1 by Glycyrrhizin is a Possible Mechanism of Tight Junction Opening of Caco-2 Cells.

2022 ◽  
Author(s):  
Emi Hibino ◽  
Natsuko Goda ◽  
Misaki Hisada ◽  
Takeshi Tenno ◽  
Hidekazu Hiroaki
Keyword(s):  
Tight Junction ◽  
Drug Absorption ◽  
Pdz Domain ◽  
Direct Inhibition ◽  
Pharmacological Activities ◽  
Intestinal Drug Absorption ◽  
Anti Inflammation

Glycyrrhizin (GL) is known to exhibit a variety of useful pharmacological activities, including anti-inflammation, anti-hepatotoxicity, and enhancement of intestinal drug absorption. GL has been reported to modify the assembly of...

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